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作者: Chandrappa S>
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摘要: Neovascular glaucoma (NVG) is a human eye disease due to diabetes that leads to permanent vision loss. Early detection and treatment of it prevent further vision loss. Hence the development of an automated system is more essential to help the ophthalmologist in detecting NVG at an earlier stage. In this paper, a novel approach is used for detection of Neovascular glaucoma using fractal geometry concepts. Fractal geometry is a branch of mathematics. It is useful in computing fractal features of i关键词: Glaucoma;Fractal Dimension (FD);Box Counting;Segmentation;Texture Features;Retina.
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Chandrappa S; Dharmanna L; Shyama Srivatsa Bhatta U V; Sudeeksha Chiploonkar M; Suraksha M N; Thrupthi S;
摘要: The conventional method of measuring the quality of water is to take the samples manually and send it to laboratory for analysis. This technique is time overwhelming and not economical. Also it is not feasible to take the water sample to the laboratory after every hour for measuring its quality. To overcome from these problems a new system is proposed in this work. This water quality measuring system will measure the essential qualities of water in real time. The proposed system consists of mult
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摘要: According to the survey of World Health Organization (WHO), the number of people getting affected by glaucoma eye disease in worldwide will be 79.11 million by the year 2020. Glaucoma is a dangerous eye disease, which can lead to permanent vision loss if not provided proper treatment at the right time. Currently ophthalmologists detect the glaucoma disease based on estimation of cup to disk ratio, but this method suffers from accurate segmentation of regions like optic disk and optic cup. Howeve关键词: Glaucoma;Optic Cup;Optic Disk;Fractal Dimension;Optic Nerve Head;Cup to Disk Ratio;Hausdrop Fractal Dimension
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Research Article
Raju H; Nagamani T S; Chandrappa S; Ananda H; Vinaya K; Thimmegowda N R; Byregowda S M; Rangappa K S;
Journal of enzyme inhibition and medicinal chemistryVolume 25, Issue 4, 2010, PP 537-43
摘要: A series of novel substituted 1-(4-methoxybenzyl)-3-cyclopropyl-1H-pyrazol-5-amine benzamides 9(a-h) were synthesized to determine their antibacterial and antifungal activities as well as possible structure-activity relationships (SARs) to improve therapeutic efficacy. The pyrazol-5-amine benzamides were screened for their antibacterial activity against standard strains of Gram-positive (Streptococcus pyogenes NCIM 2608, Staphylococcus aureus ATCC 29737, Bacillus subtilis NCIM 2010) and Gram-neg关键词: 4-methoxybenzaldehyde;3-cyclopropyl-3-oxopropanenitrile;acid chlorides;antibacterial;antifungal
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Research Article
Ranganatha S R; Kavitha C V; Vinaya K; Prasanna D S; Chandrappa S; Raghavan Sathees C; Rangappa Kanchugarakoppal S;
Archives of pharmacal researchVolume 32, Issue 10, 2009, PP 1335-43
摘要: The present work deals with the anticancer effect of benzimidazole derivatives associated with the pyridine framework. By varying the functional group at N-terminal of the benzimidazole by different L-amino acids, several 2-(4-(2,2,2-trifluoroethoxy)-3-methylpyridin-2-ylthio)-1Hbenzo[d]imidazole derivatives 9(a-j) were synthesized. Their chemical structures were confirmed by (1)H NMR, IR and mass spectroscopic techniques. The synthesized compounds were examined for their antiproliferative effect关键词: Benzimidazole;Amino acids;Cytotoxicity;Chronic myelogenous leukemia
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Research Article
Ananda Kumar C S; Kavitha C V; Vinaya K; Benaka Prasad S B; Thimmegowda N R; Chandrappa S; Raghavan Sathees C; Rangappa K S;
Investigational new drugsVolume 27, Issue 4, 2009, PP 327-37
摘要: To study the structure activity relationship (SAR) on the cytotoxic activity and probe the structural requirement for the potent antitumor activity, a series of novel diazaspiro bicyclo hydantoin derivatives were designed and synthesized. Their structures were confirmed by (1)H NMR, LCMS and IR analyses. The antiproliferative effect of these compounds were determined against human leukemia, K562 (chronic myelogenous leukemia) and CEM (T-cell leukemia) cells using trypan blue and MTT assay, and t关键词: Diazaspiro bicyclo hydantoin;Cytotoxic activities;Trypan blue dye exclusion assay;MTT assay;Leukemia;SAR
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Journal
Research Article
Ananda Kumar C S; Prasad S B Benaka; Vinaya K; Chandrappa S; Thimmegowda N R; Ranganatha S R; Swarup Sanjay; Rangappa K S;
Investigational new drugsVolume 27, Issue 2, 2009, PP 131-9
摘要: In the course of structure-activity relationship studies and to explore the antiproliferative effect associated with the hydantoin framework, diversely substituted several diazaspiro hydantoins were synthesized. Variation in the functional group at N-terminal of the hydantoin ring and coupling of different substituted aromatic acids in 4-aminocyclohexanone ring led to three sets of compounds. The antiproliferative effect of the compounds was evaluated in vitro using the MTT colorimetric method a关键词: Diazaspiro hydantoins;4-amino cyclohexanone;Antiproliferative activity;Cell proliferation;Carcinoma cell lines;MTT assay
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Journal
Research Article
Vinaya K; Kavitha R; Ananda Kumar C S; Benaka Prasad S B; Chandrappa S; Deepak S A; Nanjunda Swamy S; Umesha S; Rangappa K S;
Archives of pharmacal researchVolume 32, Issue 1, 2009, PP 33-41
摘要: Several 1-benzhydryl-sulfonyl-4-(3-(piperidin-4-yl)propyl)piperidine derivatives 8(a-j) were prepared by the treatment of substituted benzhydryl chlorides with 4-(3-(piperidin-4-yl)propyl)piperidine followed by N-sulfonation with sulfonyl chlorides in the presence of dry methylene dichloride and triethyl amine. The synthesized compounds were characterized by (1)H-NMR, IR, and elemental analysis. All the synthesized compounds were evaluated in vitro for their efficacy as antimicrobial agents by a关键词: Benzhydryl chloride;4-(3-(Piperidin-4-yl)propyl)piperidine;Sulfonyl chlorides;Lycopersicon esculentum;Structure activity relationship;Antimicrobial activity
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Research Article
摘要: A series of novel 5-(4-methyl-benzylidene)-thiazolidine-2,4-dione derivatives 6 (a-d) and 7 (a-g) were synthesized with different substituted aromatic sulfonyl chlorides (R-SO(2)-Cl) and alkyl halides (R-X) and were characterized by (1)H NMR, LC/MS, FTIR and elemental analyses. All the compounds synthesised were evaluated for their cell antiproliferation activity by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The antiproliferative effects of the synthesised compoun关键词: Thiazolidine-2,4-one;Sulfonyl chloride;MTT assay;Antiproliferative activity;Cancer therapy;Cell proliferation
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Journal
Thimmegowda N R; Nanjunda Swamy S; Kumar C S Ananda; Kumar Y C Sunil; Chandrappa S; Yip George W; Rangappa K S;
Bioorganic & medicinal chemistry lettersVolume 18, Issue 1, 2008, PP 432-5
摘要: A novel series of trisubstituted benzimidazole and its precursors (3-7) were synthesised and characterized by using 1H NMR, LC/MS, FTIR and elemental analysis techniques. The title compounds were evaluated for inhibition against MDA-MB-231 breast cancer cell proliferation. The results revealed that the compound N-(4-cyano-3-(trifluoromethyl) phenyl)-4-fluoro-3-nitrobenzamide (3) was the potent inhibitor.
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