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Journal
摘要: The ongoing pandemic caused by the novel coronavirus, SARS-CoV-2, is influencing global health. Moreover, there is a major threat of future coronaviruses affecting the entire world in a similar, or even more dreadful, manner. Therefore, effective and biocompatible therapeutic options against coronaviruses are urgently needed. To address this challenge, medical specialists require a well-informed and safe approach to treating human coronaviruses (HCoVs). Herein, an environmental friendly approach关键词: Nitric oxide enriched plasma-activated water;Microwave plasma;Coronavirus;Virus inactivation;Gene expression
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Book Chapter
摘要: The respiratory system supplies oxygen to meet the body’s demands. When respiratory distress arises, there is a problem in any of the pathways leading to oxygenation, ventilation, or both. Respiratory distress can occur for a variety of reasons and present with differing levels of severity. Pertinent history and directed physical exam are crucial to determining the etiology of the respiratory distress as well as choosing the right diagnostic studies and proceeding to appropriate treatment. Under关键词: respiratory distress;respiratory failure;asthma;bronchiolitis;e-cigarettes;vaping;e-cigarette or vaping product use–associated lung injury (EVALI);pneumonia;croup;COVID-19;coronavirus
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Book Chapter
Seethala Raghu;Takhar Sukhjit S.;
Rosen's Emergency MedicineVolume , Issue , 2023, PP 1635-1640.e1
摘要: Most human coronaviruses cause mild disease. Three coronaviruses, SARS, MERS, and COVID-19, have caused severe disease in humans. The hallmark presentation of severe disease in coronavirus patients is respiratory failure, usually manifesting as acute respiratory distress syndrome (ARDS). The vast majority of children have a benign disease course. However, a small number may develop a severe hyperinflammatory illness called multisystem inflammatory syndrome in children (MIS-C). Public health meas关键词: coronavirus;SARS;MERS;COVID-19
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Journal
Sikkema Reina S;Tobias Tijs;Oreshkova Nadia;de Bruin Erwin;Okba Nisreen;Chandler Felicity;Hulst Marcel M;Rodon Jordi;Houben Manon;van Maanen Kees;Bultman Hans;Meester Marina;Gerhards Nora M;Bouwknegt Martijn;Urlings Bert;Haagmans Bart;Kluytmans Jan;GeurtsvanKessel Corine H;van der Poel Wim H M;Koopmans Marion P G;Stegeman Arjan;
Emerging microbes & infectionsVolume 11, Issue 1, 2022, PP 91-94
摘要: In order to assess the risk of SARS-CoV-2 infection, transmission and reservoir development in swine, we combined results of an experimental and two observational studies. First, intranasal and intratracheal challenge of eight pigs did not result in infection, based on clinical signs and PCR on swab and lung tissue samples. Two serum samples returned a low positive result in virus neutralization, in line with findings in other infection experiments in pigs. Next, a retrospective observational st关键词: Coronavirus;One Health;SARS-CoV-2;Swine;antibody
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Journal
Sanghavi Devang;Bansal Pankaj;Kaur Ikwinder Preet;Mughal Mohsin Sheraz;Keshavamurthy Chandana;Cusick Austin;Schram Jennifer;Yarrarapu Siva Naga S;Giri Abhishek R;Kaur Nirmaljot;Moreno Franco Pablo;Abril Andy;Aslam Fawad;
Annals of medicineVolume 54, Issue 1, 2022, PP 775-789
摘要: INTRODUCTION(#br) Colchicine, because of its anti-inflammatory and possible anti-viral properties, has been proposed as potential therapeutic option for COVID-19. The role of colchicine to mitigate "cytokine storm" and to decrease the severity and mortality associated with COVID-19 has been evaluated in many studies. (#br)OBJECTIVE(#br) To evaluate the role of colchicine on morbidity and mortality in COVID-19 patients. (#br)METHODS(#br) This systematic review was conducted in accordance with the关键词: COVID-19;Colchicine;Coronavirus
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Journal
摘要: The COVID-19 pandemic has disrupted medical education worldwide. Universities were forced to rapidly adapt to the evolving situation and develop methods of delivering curricula and assessments online. The purpose of this scoping review was to assess the impact of COVID-19 on medical education and investigate how this effect varies in different income countries. The methodology adhered to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) extension for scoping reviews. Ke关键词: COVID-19;coronavirus;education;high-income;low-income;medical;middle-income;students;teachers;technology
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Journal
D'Ardes Damiano;Tana Claudio;Salzmann Alessandro;Ricci Fabrizio;Guagnano Maria Teresa;Giamberardino Maria Adele;Cipollone Francesco;
Annals of medicineVolume 54, Issue 1, 2022, PP 1140-1149
摘要: The SARS-CoV-2 pandemic is considered one of the most critical global health emergencies in the last century. The diagnostic approach to the novel coronavirus disease (COVID-19) and its possible complications through a point-of-care-ultrasound (POCUS) evaluation could represent a good solution in the primary care setting. POCUS is a non-invasive technique that can be used outside hospitals to screen COVID-19 patients and their complications safely. Moreover, it offers several applications of dia关键词: COVID-19;Novel coronavirus disease;SARS-CoV-2;healthcare;hospital;primary care;ultrasound
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Journal
Hausburg Melissa A.;Williams Jason S.;Banton Kaysie L.;Mains Charles W.;Roshon Michael;Bar-Or David;
Clinical Immunology CommunicationsVolume 2, Issue , 2022, PP 83-90
摘要: From asymptomatic to severe, SARS-CoV-2, causative agent of COVID-19, elicits varying disease severities. Moreover, understanding innate and adaptive immune responses to SARS-CoV-2 is imperative since variants such as Omicron negatively impact adaptive antibody neutralization. Severe COVID-19 is, in part, associated with aberrant activation of complement and Factor XII (FXIIa), initiator of contact system activation. Paradoxically, a protein that inhibits the three known pathways of complement a关键词: COVID-19;C1-INH;C1 esterase inhibitor;Complement;Inflammation;FXII;Severe acute respiratory syndrome coronavirus;C1 esterase inhibitor;coronavirus disease 2019;serine protease inhibitor;contact system;interferon;mannose-binding lectin;prekallikrein;activated plasma kallikrein;high-molecular-weight kininogen;bradykinin;interleukin;Mycobacterium tuberculosis;tuberculosis;human immunodeficiency virus;Middle East respiratory syndrome coronavirus;acquired C1-INH deficiency;hereditary angioedema;ischemia/reperfusion injury;antibody-mediated rejection;recombinant C1-INH;exogenous C1-INH
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Journal
摘要: Despite a huge effort by the scientific community to determine the animal reservoir of SARS-CoV-2, which led to the identification of several SARS-CoV-2-related viruses both in bats and in pangolins, the origin of SARS-CoV-2 is still not clear. Recently, Temmam et al. reported the discovery of bat coronaviruses with a high degree of genome similarity with SARS-CoV-2, especially concerning the RBDs of the S protein, which mediates the capability of such viruses to enter and therefore infect human关键词: BANAL;Laos;MPro;Paxlovid;SARS-CoV-2;bat coronavirus;sarbecovirus
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Journal
摘要: We fit an SARS-CoV-2 model to US data of COVID-19 cases and deaths. We conclude that the model is not structurally identifiable. We make the model identifiable by prefixing some of the parameters from external information. Practical identifiability of the model through Monte Carlo simulations reveals that two of the parameters may not be practically identifiable. With thus identified parameters, we set up an optimal control problem with social distancing and isolation as control variables. We in关键词: Coronavirus disease 2019 (COVID-19);Practical and structural identifiability;Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2);asymptomatic transmission;basic reproductive number;epidemic model;isolation;mass-action incidence;outbreak
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Journal
摘要: We analyze President Trump’s Twitter posts on the COVID-19 pandemic to quantitatively construct his sentiment proxy to examine its predictive power in industry-level equity returns. With the growing influence of social media, some “special” people have been able to use their celebrity status for wielding significant market influence, thereby causing a new modern crisis. This study parsed words from 2574 tweets from President Trump’s Twitter account to explore the predictive power of his sentimen关键词: G01;G02;G14;G15;Coronavirus;COVID-19;Market reactions;Trump Twitter;US industries
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Journal
Vélez Christopher;Paz Mary;Skarbinski Kristina;Minami Christina;Murray Helen Burton;Bergmark Regan;Staller Kyle;Kuo Braden;
PEC InnovationVolume 1, Issue , 2022, PP
摘要: Objective(#br)Normal elective outpatient care has been impacted during the COVID-19 pandemic, due to limitations imposed by healthcare systems. Clear communication is necessary to address patient concerns as resumption of elective care gains pace.(#br)Methods(#br)Thirty patients who had diagnostic gastrointestinal (GI) testing within our motility lab during the initial viral surge in our state spring 2020 underwent semi-structured interviews. Codes were derived from transcripts using the constan关键词: Endoscopy;Telemedicine;Coronavirus;Pandemic
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Journal
Hasan Syed Shahzad;Rashid Abdur;Osama Sundus;Mustafa Zia Ul;Merchant Hamid A.;
Clinical Immunology CommunicationsVolume 2, Issue , 2022, PP 91-97
摘要: Covid immunization commenced on 2nd Feb 2021 in Pakistan and as of 7th Sep 2021, over 84 million vaccine doses were administered in Pakistan, of which 72% procured by the government, 22% received through Covax and 6% were donated. The vaccines rolled out nationally included: Sinopharm, Sinovac and CanSinoBIO (China), AstraZeneca (UK), Moderna and Pfizer (USA), Sputnik (Russia), and PakVac (China/Pakistan). About half of the eligible population in Pakistan (63 m) had received at least one dose of关键词: Pharmacovigilance;VAERS;Yellow-Cards;COVID;SARS-COV-2;Coronavirus;Covid vaccine
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Journal
Mirenayat Maryam Sadat;Abedini Atefeh;Kiani Arda;Eslaminejad Alireza;Adimi Naghan Parisa;Malekmohammad Majid;Heshmatnia Jalal;Nadji Seyed Alireza;Idani Esmaeil;Zahiri Reyhaneh;Lookzadeh Somayeh;Sheikhzade Hakimeh;Dastan Farzaneh;Porabdollah Toutkaboni Mihan;Rezaei Mitra Sadat;Askari Elham;Tabarsi Payam;Marjani Majid;Moniri Afshin;Hashemian Seyed Mohammad Reza;Farzanegan Behrooz;Abtahian Zahra;Yassari Fatemeh;Mansouri Nazanin;Mansouri Davood;Vasheghani Maryam;Mansourafshar Babak;Mokhber Dezfoli Mojtaba;Soleimani Salman;Seifi Sharareh;Naghashzadeh Farah;Fakharian Atefeh;Varahram Mohammad;Jamaati Hamidreza;Zali Alireza;Velayati Ali Akbar;
Iranian journal of pharmaceutical research : IJPRVolume 21, Issue 1, 2022, PP e123947-e123947
摘要: More than a year after the onset of the coronavirus disease pandemic in 2019, the disease remains a major global health issue. During this time, health organizations worldwide have tried to provide integrated treatment guidelines to control coronavirus disease 2019 (COVID-19) at different levels. However, due to the novel nature of the disease and the emergence of new variants, medical teams' updating medical information and drug prescribing guidelines should be given special attention. This ver关键词: Acute Respiratory Distress Syndrome (ARDS);Clinical Management;Coronavirus Disease;SARS-COV-2;Treatment Guidelines
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Journal
Lee Gyeong-Tae;Nam Hyeonuk;Kim Seong-Hu;Choi Sang-Min;Kim Youngkey;Park Yong-Hwa;
Expert Systems With ApplicationsVolume 206, Issue , 2022, PP 117811-117811
摘要: Coughing is a typical symptom of COVID-19. To detect and localize coughing sounds remotely, a convolutional neural network (CNN) based deep learning model was developed in this work and integrated with a sound camera for the visualization of the cough sounds. The cough detection model is a binary classifier of which the input is a two second acoustic feature and the output is one of two inferences (Cough or Others). Data augmentation was performed on the collected audio files to alleviate class 关键词: Cough detection;Coronavirus;COVID-19;Deep learning;Feature engineering;Sound visualization
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Journal
摘要: The subject of economic recovery after the Coronavirus pandemic has received much attention in the media and by academics in recent years. Pandemic experience creates a new transition between the pre-pandemic era trend and the post-pandemic era trend related to the major economic indicators’ time series path. This paper offers a new smooth transition model and a unit root testing procedure to test null of non-stationary against the alternatives of stationary that allow for a pit shape smooth tra关键词: Smooth transition;Structural change;Stationary process;Economic recovery;Coronavirus
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Journal
Virginia Anikwe Chioma;Friday Nweke Henry;Chukwu Ikegwu Anayo;Adolphus Egwuonwu Chukwunonso;Uchenna Onu Fergus;Rita Alo Uzoma;Wah Teh Ying;
Expert Systems With ApplicationsVolume 202, Issue , 2022, PP
摘要: Mobile and wearable devices embedded with multiple sensors for health monitoring and disease diagnosis are growing fields with the potential to provide efficient means for remote health management. A sensor-based health monitoring system offers an essential mechanism for real-time diagnosis and management to detect/predict, recommend treatment and prevent the onset of diseases. This paper aims to synthesize the research efforts on mobile and wearable sensors for health monitoring. It will invest关键词: Machine learning;Mobile and wearable sensors;Health monitoring;Disease management;Internet of things;Coronavirus;Review
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Journal
摘要: This study presents an optimal control strategy through a mathematical model of the Covid-19 outbreak without lock-down. The pandemic model analyses the lock-down effect without control strategy based on the current scenario of second wave data to control the rapid spread of the virus. The pandemic model has been discussed with respect to the basic reproduction number and stability analysis of disease-free and endemic equilibrium. A new optimal control problem with treatment is framed to minimiz关键词: Optimal control;Epidemiology;Reproduction number;Stability;Novel coronavirus
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Journal
关键词: Adverse reactions;COVID-19;COVID-19, coronavirus disease-19;ICH, intracerebral hemorrhaghe;MRI, magnetic resonance imaging;SARS-CoV-2;SARS-CoV-2, severe, acute respiratory syndrome-coronavirus-2;Side effects;VST, venous sinus thrombosis;Vaccination
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Journal
Iyer Rajeev Subramanyam;Matava Clyde;Alessandro Vittori;Drum Elizabeth T.;Dalal Priti G.;Evans Faye;Griffis Heather;Liu Hongyan;Kajal Kamal;Puri Goverdhan D.;Varghese Elsa;Fiadjoe John E.;
Journal of Clinical AnesthesiaVolume 80, Issue , 2022, PP 110881-110881
关键词: COVID-19;Coronavirus;High-income countries;Low middle income countries;Personal protective equipment;SARS-CoV-2;Survey
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Journal
Barros-Neto João Araújo;Mello Carolina Santos;Vasconcelos Sandra Mary Lima;Bádue Gabriel Soares;Ferreira Raphaela Costa;Andrade Maria Izabel Siqueira de;Nascimento Carlos Queiroz do;Macena Mateus de Lima;Silva José Adailton da;Clemente Heleni Aires;Petribu Marina de Moraes Vasconcelos;Dourado Keila Fernandes;Pinho Claudia Porto Sabino;Vieira Renata Adrielle Lima;Mello Leilah Barbosa de;Neves Mariana Brandão das;Jesus Camila Anjos de;Santos Tatiana Maria Palmeira dos;Soares Bruna Lúcia de Mendonça;Medeiros Larissa de Brito;França Amanda Pereira de;Sales Ana Lina de Carvalho Cunha;Furtado Elane Viana Hortegal;Oliveira Alane Cabral;Farias Fernanda Orrico;Freitas Mariana Carvalho;Bueno Nassib Bezerra;
NutritionVolume 101, Issue , 2022, PP 111677-111677
摘要: Objectives(#br)The present study aimed to identify associations between extremes in body weight status (underweight and excess body weight) before a COVID-19 diagnosis and clinical outcomes in patients infected with SARS coronavirus type 2.(#br)Methods(#br)A multicenter cohort study was conducted in eight different states in northeastern Brazil. Demographic, clinical (previous diagnosis of comorbidities), and anthropometric (self-reported weight and height) data about individuals who tested posi关键词: Body mass index;Coronavirus;Hospitalization;Mechanical ventilation;Mortality
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Journal
Araújo Leonardo Pereira de;Dias Maria Eduarda Carvalho;Scodeler Gislaine Cristina;Santos Ana de Souza;Soares Letícia Martins;Corsetti Patrícia Paiva;Padovan Ana Carolina Barbosa;Silveira Nelson José de Freitas;de Almeida Leonardo Augusto;
ImmunoInformaticsVolume 7, Issue , 2022, PP
摘要: The short time between the first cases of COVID-19 and the declaration of a pandemic initiated the search for ways to stop the spread of SARS-CoV-2. There are great expectations regarding the development of effective vaccines that protect against all variants, and in the search for it, we hypothesized the obtention of a predicted rational immunogenic peptide from structural components of SARS-CoV-2 might help the vaccine research direction. In the search for a candidate of an immunogenic peptide关键词: COVID-19;New coronavirus;Reverse vaccinology;SARS-CoV-2
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Journal
摘要: The world is still suffering from the SARS-CoV-2 pandemic, and the number of infected people is still growing in many countries in 2022. Although great strides have been made to produce effective vaccines, efforts in this field should be accelerated, particularly due to the emergence of new variants. Using inactivated viruses is a conventional method of vaccine production. High levels of ionizing radiation can effectively inactivate viruses. Recently, studies on SARS-CoV-2 irradiation using low-关键词: Coronavirus;SARS-CoV-2;Vaccine;Monte Carlo;Geant4;SARS-CoV-2;RNA;DNA;bp;LET;PDB;MeV/n
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Journal
摘要: Background(#br) Bangladesh is a lower-middle-income country affected by a severe lack of mental health service availability due to a scarcity of mental health experts, limited mental health literacy, and community stigma. In other low and middle-income countries, the online provision of mental health care services has addressed issues affecting service availability, accessibility, mass awareness of services, and stigma. (#br)Objective(#br) The current study sought to understand stakeholders' per关键词: Bangladesh;CMD, Common Mental Health Disorders;COREQ, Consolidated Reporting Criteria for Qualitative Studies;COVID-19, Coronavirus Disease 2019;DALYs, Disability-Adjusted Life-Years;Digital technology;E-mental health;FGD, Focus Group Discussions;HIC, High Income Country;Health system;IDI, In-Depth Interviews;IRB, Institutional Review Board;Internet;KII, Key Informant Interviews;LMIC, Low and Middle-Income Country;MH, Mental Health;Mental health;PWLE, People with Lived Experiences of Mental Health Issues;UHC, Universal Health Coverage;WHO, World Health Organization
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Journal
摘要: It remains unclear how COVID-19 has affected public engagement with the climate crisis. According to the finite-pool-of-worry hypothesis, concern about climate change should have decreased after the pandemic, in turn reducing climate-policy acceptance. Here we test these and several other conjectures by using survey data from 1172 Spanish participants who responded before and after the first wave of COVID-19, allowing for both aggregate and within-person analyses. We find that on average climate关键词: Climate change;Climate policy;Coronavirus;Panel study;Policy support
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Journal
Smit Liezl;Redfern Andrew;Murray Sadia;Lishman Juanita;van der Zalm Marieke M;van Zyl Gert;Verhagen Lilly M;de Vos Corné;Rabie Helena;Dyk Annemarie;Claassen Mathilda;Taljaard Jantjie;Aucamp Marina;Dramowski Angela;
摘要: Background(#br) Identification of SARS-CoV-2 infected individuals is imperative to prevent hospital transmission, but symptom-based screening may fail to identify asymptomatic/mildly symptomatic infectious children and their caregivers. (#br)Methods(#br) A COVID-19 period prevalence study was conducted between 13 and 26 August 2020 at Tygerberg Hospital, testing all children and their accompanying asymptomatic caregivers after initial symptom screening. One nasopharyngeal swab was submitted for 关键词: COVID-19, Coronavirus-19;Children and accompanying caregivers;SARS-CoV-2;SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2;Symptom screening
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Journal
摘要: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is primarily transmitted from human to human via droplets and aerosols. While transmission via contaminated surfaces is also considered possible, the overall risk of this transmission route is assumed to be low. Nevertheless, transmission through contaminated drinking glasses may pose an increased risk as the glass is in direct contact with the mouth and oral cavity. Using human coronavirus 229E (HCoV-229E) as surrogate for SARS-C关键词: Human coronavirus;Stability;Inactivation;Glass;Detergent;Manual dishwashing
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Journal
摘要: Background(#br)Initially, novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) was considered primarily a respiratory pathogen. However, with time it has behaved as a virus with the potential to cause multi-system involvement, including neurological manifestations which varies from acute to subacute onset of headache, seizures, a decrease of consciousness, and paralysis.(#br)Case description(#br)Two cases of cerebral sinus venous thrombosis in COVID-19 patients were reported, followi关键词: Corona virus disease 2019 (COVID-19);Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2);Cerebral venous sinus thrombosis (CVST);Venous thrombotic events (VTE);Neurologic manifestations
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Journal
摘要: Polyoxidometalates (POMs) exhibit a range of biological properties that can be exploited for a variety of therapeutic applications. However, their potential utility as antivirals has been largely overlooked in the ongoing efforts to identify safe, effective and robust therapeutic agents to combat COVID-19. We focus on decavanadate (V10), a paradigmatic member of the POM family, to highlight the utility of electrostatic forces as a means of disrupting molecular processes underlying the SARS-CoV-2关键词: Polyoxidometalate;Vanadium;Coronavirus;Therapeutics;Antiviral agent;Polyanion
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Journal
Ferguson Elaine A.;Brum Eric;Chowdhury Anir;Chowdhury Shayan;Kundegorski Mikolaj;Mahmud Ayesha S.;Purno Nabila;Sania Ayesha;Steenson Rachel;Tasneem Motahara;Hampson Katie;
EpidemicsVolume 40, Issue , 2022, PP 100592-100592
摘要: Background(#br)Non-pharmaceutical interventions (NPIs) used to limit SARS-CoV-2 transmission vary in their feasibility, appropriateness and effectiveness in different contexts. In Bangladesh a national lockdown implemented in March 2020 exacerbated poverty and was untenable long-term. A resurgence in 2021 warranted renewed NPIs. We sought to identify NPIs that were feasible in this context and explore potential synergies between interventions.(#br)Methods(#br)We developed an SEIR model for Dhaka关键词: Coronavirus disease 2019 (COVID-19);Non-pharmaceutical interventions (NPIs);Low- and middle- income countries (LMICS);Cost-effectiveness;Facemasks
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