PubMed期刊
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作者:Bielewicz Joanna , Szczepańska-Szerej Anna , Ogórek Magdalena ...
来源:[J].Prion, 2018, pp.1-4PubMed
摘要:We reported the case of a patient with Wernicke-Korsakoff syndrome (WKs) as an early clinical manifestation of sporadic Creutzfeld-Jakob disease (sCJD). The 66-year-old female complained of dizziness and imbalance which mostly occurred while walking. A neurological examination re...
作者:Lee Sol Moe , Lee Wonseok , Lee Yeong Seon ...
来源:[J].Prion, 2018, pp.1-8PubMed
摘要:Prion diseases are fatal neurodegenerative disorders that affect humans and animals. Although various small molecules have been evaluated for application in the treatment of prion diseases, none have been shown to be efficacious. Expanding our knowledge of these molecules is impo...
作者:Li Jie , Zhang Shaoli , Erdenee Sarantsetseg ...
来源:[J].Prion, 2018, pp.1-28PubMed
摘要:Studies of the ovine prion-related protein (testis-specific) gene (PRNT), including studies of genetic diversity, have highlighted its potential relationship to scrapie infection and economically important ovine traits. PRNT was previously reported to be highly polymorphic in Por...
作者:Martellucci Stefano , Manganelli Valeria , Santacroce Costantino ...
来源:[J].Prion, 2018, pp.0PubMed
摘要:Cellular prion protein (PrPC) is expressed in a wide variety of stem cells in which regulates their self-renewal as well as differentiation potential. In this study we investigated the presence of PrPC in human dental pulp-derived stem cells (hDPSCs) and its...
作者:Baskakov Ilia V , Caughey Byron , Requena Jesús R ...
来源:[J].Prion, 2019PubMed
摘要:Understanding the structure of PrPSc is without doubt a sine qua non to understand not only PrPSc propagation, but also critical features of that process such as the strain phenomenon and transmission barriers. While elucidation of the PrPSc structure has been full of diffic...
作者:Sergeeva A V , Sopova J V , Belashova T A ...
来源:[J].Prion, 2019, Vol.13 (1), pp.21-32PubMed
摘要:Amyloids are non-branching fibrils that are composed of stacked monomers stabilized by intermolecular β-sheets. Some amyloids are associated with incurable diseases, whereas others, functional amyloids, regulate different vital processes. The prevalence and significance of f...
作者:Iwasaki Yasushi , Hashimoto Rina , Saito Yufuko ...
来源:[J].Prion, 2019, Vol.13 (1), pp.13-20PubMed
摘要:An 83-year-old Japanese man presented with gait disturbance followed by rapidly-progressive cognitive impairment. Magnetic resonance diffusion-weighted images showed extensive hyperintense regions in the cerebral cortex. Four weeks after symptom onset, myoclonus appeared, and the...
作者:Gordenin Dmitry A , Mironova Ludmila N
来源:[J].Prion, 2019, Vol.13 (1), pp.33-36PubMed
摘要:This commentary is a tribute to the late colleague, Prof. Michael D. Ter-Avanesyan - prominent contributor into knowledge about prion maintenance and function. The commentary describes his early steps in genetics which brought him into prion research.

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