PubMed期刊
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作者:Dodds Sherry G , Livi Carolina B , Parihar Manish ...
来源:[J].Pathobiology of aging & age related diseases, 2016, Vol.6, pp.31688PubMed
摘要:Rapamycin inhibits mechanistic (or mammalian) target of rapamycin (mTOR) that promotes protein production in cells by facilitating ribosome biogenesis (RiBi) and eIF4E-mediated 5'cap mRNA translation. Chronic treatment with encapsulated rapamycin (eRapa) extended health and life ...
作者:Keene C Dirk , Darvas Martin , Kraemer Brian ...
来源:[J].Pathobiology of aging & age related diseases, 2016, Vol.6, pp.32397PubMed
摘要:Dozens of transgenic mouse models, generally based on mutations associated with familial Alzheimer's disease (AD), have been developed, in part, for preclinical testing of candidate AD therapies. However, none of these models has successfully predicted the clinical efficacy ...
作者:Lelegren Matthew , Liu Yuhong , Ross Corinna ...
来源:[J].Pathobiology of aging & age related diseases, 2016, Vol.6, pp.31793PubMed
摘要:Inhibition of mechanistic target of rapamycin (mTOR) has emerged as a viable means to lengthen lifespan and healthspan in mice, although it is still unclear whether these benefits will extend to other mammalian species. We previously reported results from a pilot experiment where...
作者:Drosatos Konstantinos
来源:[J].Pathobiology of aging & age related diseases, 2016, Vol.6, pp.32221PubMed
摘要:Age-related cardiomyopathy accounts for a significant part of heart failure cases. Imbalance of the energetic equilibrium of the heart along with mitochondrial dysfunction and impaired β-adrenergic receptor signaling contributes in the aggravation of cardiac function in the ...
作者:Ge Xuan , Cho Anthony , Ciol Marcia A ...
来源:[J].Pathobiology of aging & age related diseases, 2016, Vol.6, pp.32981PubMed
摘要:The hand grip test has been correlated with mobility and physical performance in older people and has been shown to be a long-term predictor of mortality. Implementation of new strategies for enhancing healthy aging and maintaining independent living are dependent on predict...
作者:Schorr Anna , Carter Christy , Ladiges Warren
来源:[J].Pathobiology of aging & age related diseases, 2018, Vol.8 (1), pp.1403844PubMed
摘要:Physical resilience is the ability of an organism to respond to stressors that acutely disrupt normal physiological homeostasis. By definition, resilience decreases with increasing age, while frailty, defined as a decline in tissue function, increases with increasing age. Assessm...
来源:[J].Age and ageing(IF 3.816), 1979, Vol.8 (4), pp.251-302PubMed

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