PubMed期刊
期刊
会议
图书
作者:Karasik David
来源:[J].Age, 2010, Vol.33 (1), pp.49-62PubMed
摘要:Genetic study can provide insight into the biologic mechanisms underlying inter-individual differences in susceptibility to (or resistance to) organisms' aging. Recent advances in molecular genetics and genetic epidemiology provide the necessary tools to perform a study of the ge...
作者:Gomez-Pinilla Pedro J , Pozo Maria J , Camello Pedro J
来源:[J].Age, 2010, Vol.33 (1), pp.81-8PubMed
摘要:Although aging-induced changes in urinary bladder neurotransmission have been studied in some detail, information regarding alterations in detrusor muscle is scanty and addresses only partial aspects of the myogenic response of detrusor. Rodent bladder aging shows several feature...
作者:Salway Kurtis D , Page Melissa M , Faure Paul A ...
来源:[J].Age, 2010, Vol.33 (1), pp.33-47PubMed
摘要:Previous studies have shown that longevity is associated with enhanced cellular stress resistance. This observation supports the disposable soma theory of aging, which suggests that the investment made in cellular maintenance will be proportional to selective pressures to ex...
作者:Kedmi Merav , Orr-Urtreger Avi
来源:[J].Age, 2010, Vol.33 (1), pp.1-13PubMed
摘要:Aging is accompanied by expression changes in multiple genes, and the brain is one of the tissues most vulnerable to aging. Since the α7 nicotinic acetylcholine receptor (nAChR) subunit has been associated with neurodevelopmental disorders and cognitive decline during aging,...
作者:Ferrando-Martínez Sara , Ruiz-Mateos Ezequiel , Hernández Ana ...
来源:[J].Age, 2010, Vol.33 (2), pp.197-207PubMed
摘要:Immunosenescence is characterized by phenotypic and functional changes of effector memory T cells. In spite of the well-described senescent defects of these experienced T cells, immune responses to new pathogens are also deeply affected in elderly humans, suggesting that naive T ...
作者:Hooi Michelle Yu Sung , Truscott Roger J W
来源:[J].Age, 2010, Vol.33 (2), pp.131-41PubMed
摘要:ASTRACT: Several amino acids were found to undergo progressive age-dependent racemisation in the lifelong proteins of normal human lenses. The two most highly racemised were Ser and Asx. By age 70, 4.5% of all Ser residues had been racemised, along with >9% of Asx residues. Such ...
作者:Sharma Praveen Kumar , Agrawal Vineet , Roy Nilanjan
来源:[J].Age, 2010, Vol.33 (2), pp.143-54PubMed
摘要:Calorie restriction (CR) is the only proven regimen, which confers lifespan extension benefits across the various phyla right from unicellular organisms like yeast to primates. In a bid to elucidate the mechanism of calorie-restriction-mediated life span extension, the role of mi...
作者:Sanchez-Alavez Manuel , Alboni Silvia , Conti Bruno
来源:[J].Age, 2010, Vol.33 (1), pp.89-99PubMed
摘要:Gender-specific differences in longevity are reported across species and are mediated by mechanisms not entirely understood. In C57Bl/6 mice, commonly used in aging research, males typically outlive females. Since in these animals modest but prolonged reduction of core body (Tc) ...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×