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作者:Michael Schmohl , Stephan Glund , Akiko Harada ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (2), pp.269-276
摘要:Idarucizumab, a humanised monoclonal antibody fragment, binds dabigatran with high affinity and immediately, completely and sustainably reverses dabigatran-induced changes on blood coagulation. The present analysis focuses on the evaluation of potential procoagulant properties of...
作者:Ammar Majeed , Niklas Wallvik , Joakim Eriksson ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.491-499
摘要:The optimal timing of vitamin K antagonists (VKAs) resumption after an upper gastrointestinal (GI) bleeding, in patients with continued indication for oral anticoagulation, is uncertain. We included consecutive cases of VKA-associated upper GI bleeding from three hospitals r...
作者:Frederikus A. Klok , Stefano Barco , Stavros V. Konstantinides
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1164-1170
摘要:One of the main determinants of establishing the optimal treatment duration of patients with venous thromboembolism (VTE) is the risk of major bleeding during long-term anticoagulant therapy. The 6-variable VTE-BLEED score was recently developed to enable estimation of this ...
作者:Armando Tripodi
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (5), pp.830-836
摘要:Each individual possesses his/her own endogenous-thrombin-potential (ETP) (i. e. the ability to generate thrombin) which depends on the relative strength of the pro- and anticoagulant drivers operating in plasma. This ability depends in turn on the clinical conditions in w...
作者:Takuma Maeda , Katsura Nakagawa , Kuniko Murata ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (1), pp.127-138
摘要:To diagnose heparin-induced thrombocytopenia (HIT), detection of platelet-activating antibodies (HIT antibodies) is crucial. However, serum platelet activation profiles vary across patients and depend on test conditions. We evaluated the association between clinical outcomes and ...
作者:Dorian L. Culmer , Misha L. Dunbar , Angela E. Hawley ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1171-1181
摘要:Selectins, such as E-selectin (CD62E), function in venous thrombosis by binding and activating immune cells to initiate the coagulation cascade. GMI-1271 is a small molecule antagonist that inhibits E-selectin activity. Here we determine whether inhibition of E-selectin is suffic...
作者:Johann Wojta
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (1), pp.6-6
作者:Cristina Barale , Simona Buracco , Franco Cavalot ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (6), pp.1115-1128
摘要:Glucagon-like peptide 1 (GLP-1) is object of intensive investigation for not only its metabolic effects but also the protective vascular actions. Since platelets exert a primary role in the pathogenesis of atherosclerosis, inflammation and vascular complications, we investig...
作者:Bin Pan , Xiangmin Wang , Shinsuke Kojima ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.570-579
摘要:Thrombomodulin (TM) exerts cytoprotection via the fifth region of epidermal growth factor (EGF)-like domain of TM (TME5) by interacting with G-protein coupled receptor 15 (GPR15) expressed on cell surface of vascular endothelial cells. TM is also implied to mediate anti-inflammat...

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