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作者:Joseph A. Jakubowski , Carolyn C. Hoppe , Chunmei Zhou ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.580-588Schattauer 出版社
摘要:Patients with sickle cell anaemia (SCA) have vaso-occlusive crises resulting from occlusive hypoxic-ischaemic injury. Prasugrel inhibits platelet activation and aggregation involved in SCA pathophysiology. Determining Effects of Platelet Inhibition on Vaso-Occlusive Events (...
作者:Katie A. Greenhalgh , Mark W. Strachan , Saad Alzahrani ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (2), pp.295-302Schattauer 出版社
摘要:Both type 2 diabetes (T2DM) and Bβ448Lys variant of fibrinogen are associated with dense fibrin clots, impaired fibrinolysis and increased cardiovascular risk. It was our objective to investigate whether BβArg448Lys adds to vascular risk by modulating fibrin network str...
作者:Christos Christopoulos , Mohamed Farag , Keith Sullivan ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.457-470Schattauer 出版社
摘要:Antithrombotic medications reduce thrombosis but increase bleeding. Identification of ST-elevation myocardial infarction (STEMI) patients at risk of recurrent thrombosis could allow targeted treatment with potent antithrombotic medications, with less potent agents in others,...
作者:Luca Liberale , Franco Dallegri , Fabrizio Montecucco ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (1), pp.7-18Schattauer 出版社
摘要:Macrophages are highly heterogeneous and plastic cells. They were shown to play a critical role in all stages of atherogenesis, from the initiation to the necrotic core formation and plaque rupture. Lesional macrophages primarily derive from blood monocyte, but local macrophage p...
作者:Stefan Loroch , Katharina Trabold , Stepan Gambaryan ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.556-569Schattauer 出版社
摘要:Glanzmann thrombasthenia (GT) is one of the best characterised inherited platelet function disorders but global platelet proteome has not been determined in these patients. We investigated the proteome and function of platelets from two patients with type I GT, caused by dif...
作者:Fausto Biancari , Debora Brascia , Francesco Onorati ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.445-456Schattauer 出版社
摘要:Severe perioperative bleeding after coronary artery bypass grafting (CABG) is associated with poor outcome. An additive score for prediction of severe bleeding was derived (n=2494) and validated (n=1250) in patients from the E-CABG registry. Severe bleeding was defined as E-...
作者:Bing Zhao , Yanling Zhang , Yinong Huang ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (1), pp.44-56Schattauer 出版社
摘要:Currently, anticoagulants would be used to prevent thrombosis. Thrombin is an effector enzyme for haemostasis and thrombosis. We designed a direct thrombin inhibitor peptide (DTIP) using molecular simulation and homology modelling and demonstrated that the C-terminus of DTIP...
作者:Indira Ratnayake , Fathima Shihana , Dhammika M. Dissanayake ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.500-507Schattauer 出版社
摘要:The 20-minute whole blood clotting test (WBCT20) is used as a bedside diagnostic test for coagulopathic snake envenoming. We aimed to assess the performance of the WBCT20 in diagnosis of venom induced consumption coagulopathy (VICC) in Russell’s viper envenoming. Adult...
作者:Bin Pan , Xiangmin Wang , Shinsuke Kojima ...
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (3), pp.570-579Schattauer 出版社
摘要:Thrombomodulin (TM) exerts cytoprotection via the fifth region of epidermal growth factor (EGF)-like domain of TM (TME5) by interacting with G-protein coupled receptor 15 (GPR15) expressed on cell surface of vascular endothelial cells. TM is also implied to mediate anti-inflammat...
作者:Johann Wojta
来源:[J].Thromb Haemost(IF 6.094), 2017, Vol.117 (1), pp.6-6Schattauer 出版社

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