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作者:Xia Li , Yuwen Liu , Jie Li ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry(IF 1.495), 2004, Vol.19 (4), pp.333-8PubMed
摘要:Na+/K+-ATPase (EC 3.6.1.3) is an important membrane-bound enzyme. In this paper, kinetic studies on Na+/K+-ATPase were carried out under mimetic physiological conditions. By using microcalorimeter, a thermokinetic method was employed for the first time. Compared with other method...
作者:Chen Qing-Xi , Song Kang-Kang , Wang Qin ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry(IF 1.495), 2003, Vol.18 (6), pp.491-6PubMed
摘要:The inhibition kinetics on the diphenolase activity of mushroom tyrosinase by some alkylbenzaldehydes has been investigated. The results show that the alkylbenzaldehydes assayed can lead to reversible inhibition to the enzyme; o-tolualdehyde and m-tolualdehyde are mixed-type inhi...
作者:Sundermann Tom , Hanekamp Walburga , Lehr Matthias
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2016, Vol.31 (4), pp.653-63PubMed
摘要:Cytosolic phospholipase A2α (cPLA2α) and fatty acid amide hydrolase (FAAH) are serine hydrolases. cPLA2α is involved in the generation of pro-inflammatory lipid mediators, FAAH terminates the anti-inflammatory effects of endocannabinoids. Therefore, inhibitors of these enzym...
作者:Wróbel Tomasz M , Kiełbus Michał , Kaczor Agnieszka A ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2016, Vol.31 (4), pp.608-18PubMed
摘要:A series of urea derivatives bearing nitroaryl moiety has been synthesized and assayed for their potential antiproliferative activities. Some of the tested compounds displayed activity in RK33 laryngeal cancer cells and TE671 rhabdomyosarcoma cells while being generally less...
作者:Gul Halise Inci , Kucukoglu Kaan , Yamali Cem ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2016, Vol.31 (4), pp.568-73PubMed
摘要:In this study, 4-(2-substituted hydrazinyl)benzenesulfonamides were synthesized by microwave irradiation and their chemical structures were confirmed by (1)H NMR, (13)CNMR, and HRMS. Ketones used were: Acetophenone (S1), 4-methylacetophenone (S2), 4-chloroacetophenone (S3), ...
作者:Taslimi Parham , Gülçin İlhami , Öztaşkın Necla ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2016, Vol.31 (4), pp.603-7PubMed
摘要:Carbonic anhydrases (CAs, EC 4.2.1.1), which are involved in a variety of physiological and pathological processes, are ubiquitous metalloenzymes mainly catalyzing the reversible hydration of carbon dioxide (CO2) to bicarbonate ([Formula: see text]) and proton (H(+)). In thi...
作者:Giovannoni Maria Paola , Schepetkin Igor A , Crocetti Letizia ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2016, Vol.31 (4), pp.628-39PubMed
摘要:Compounds that can effectively inhibit the proteolytic activity of human neutrophil elastase (HNE) represent promising therapeutics for treatment of inflammatory diseases. We present here the synthesis, structure-activity relationship analysis, and biological evaluation of a new ...
作者:Beato Claudia , Pecchini Chiara , Cocconcelli Chiara ...
来源:[J].Journal of enzyme inhibition and medicinal chemistry, 2016, Vol.31 (4), pp.645-52PubMed
摘要:d-Serine is the co-agonist of NMDA receptors and binds to the so-called glycine site. d-Serine is synthesized by human serine racemase (SR). Over activation of NMDA receptors is involved in many neurodegenerative diseases and, therefore, the inhibition of SR might represent a nov...

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