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作者:Muhammad Irfan Siddique , Haliza Katas , Mohd Cairul Iqbal Mohd Amin ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (12), pp.4276-4286Wiley
摘要:Hydrocortisone ( HC ) is a topical glucocorticoid for the treatment of atopic dermatitis ( AD ); the local as well as systemic side effects limit its use. Hydroxytyrosol ( HT ) is a polyphenol present in olive oil that has strong antimicrobial and antioxidant activities. HC ...
作者:Kazutoshi Mihara , Yae Ito , Yukichi Hatano ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (12), pp.3991-3996Wiley
摘要:One major concern with biosimilars is that small differences compared with reference products might lead to unforeseen immunogenicity, thus affecting patient safety and drug efficacy. Differences could be due to either post‐translational modifications of the therapeutic prot...
作者:Marten Klukkert , Marco Van De Weert , Mathias Fanø ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (12), pp.4314-4321Wiley
摘要:The objective of this study was to investigate the influence of compaction on the conformation of trypsin, its transition temperature ( T m) of unfolding, and its folding reversibility after thermal denaturation. Plain trypsin was compacted at 40–382 MPa. Pressure...
作者:Meenakshi Pathak , Allan G. A. Coombes , Mark S. Turner ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (12), pp.4217-4222Wiley
摘要:Polycaprolactone ( PCL ) matrices loaded with doxycycline were produced by rapidly cooling suspensions of the drug powder in PCL solution in acetone. Drug loadings of 5%, 10%, and 15% (w/w) of the PCL content were achieved. Exposure of doxycycline powder to matrix processing...
作者:Marc B. Taraban , Huy C. Truong , Yue Feng ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (12), pp.4132-4141Wiley
摘要:The need for quality control during the manufacturing and distribution of biopharmaceuticals is becoming increasingly necessary. At present, detecting drug degradation through the monitoring of active factor aggregation is accomplished through “invasive” techniques, such as ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (10), pp.i-iiWiley
作者:Daniela Edith Igartúa , María Natalia Calienni , Daniela Agustina Feas ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (12), pp.4142-4152Wiley
摘要:Emulsions are gaining increasing interest to be applied as drug delivery systems. The main goal of this work was the formulation of an oil/water nutraceutical emulsion ( NE ) for oral administration, enriched in omega 3 (ω3) and omega 6 (ω6), and able to encapsulate risperid...
作者:Maya P. Lipert , Lilly Roy , Scott L. Childs ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (12), pp.4153-4163Wiley
摘要:This work examines cocrystal solubility in biorelevant media ( F e SSIF , fed‐state simulated intestinal fluid), and develops a theoretical framework that allows for the simple and quantitative prediction of cocrystal solubilization from drug solubilization. The solubilities...
作者:Matthias Manne Knopp , Niels Erik Olesen , Per Holm ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (1), pp.44-51Wiley
摘要:In this study, the influence of the preparation technique (ball milling, spray drying, and film casting) of a supersaturated amorphous dispersion on the quality of solubility determinations of indomethacin in polyvinylpyrrolidone was investigated by means of statistical anal...
作者:Christoph Thiel , Sebastian Schneckener , Markus Krauss ...
来源:[J].Journal of Pharmaceutical Sciences(IF 3.13), 2015, Vol.104 (1), pp.191-206Wiley
摘要:Transfer of knowledge along the different phases of drug development is a fundamental process in pharmaceutical research. In particular, cross‐species extrapolation between different laboratory animals and further on to first‐in‐human trials is challenging because of th...

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