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作者:Daniel Sironi , Jörg Rosenberg , Annette Bauer-Brandl ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2017, Vol.96, pp.20-27Elsevier
摘要:Abstract(#br)The aim of the current study was to evaluate a dynamic dissolution-/permeation-system for prediction of gastrointestinal and absorption-behavior of two commercial fenofibrate formulations. To this end, both dissolution and barrier-flux were followed simultaneous...
作者:Giovanna Poce , Sara Consalvi , Martina Cocozza ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2017, Vol.99, pp.17-23Elsevier
摘要:Abstract(#br)BM635 is a small molecule endowed with outstanding anti-mycobacterial activity (minimum inhibitory concentration of 0.12 μM against M. tuberculosis H37Rv) identified during a hit-to-lead campaign. Its poor aqueous solubility together with its high lipophilicity ...
作者:Michaela Guter , Miriam Breunig
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2017, Vol.113, pp.34-49Elsevier
摘要:Abstract(#br)Hyaluronan (HA) is a naturally occurring polysaccharide and well known for its exceptional properties such as high biocompatibility and biodegradability, along with a low immunogenicity. Besides its use for various biomedical applications it recently came into f...
作者:Y. Alkhatib , M. Dewaldt , S. Moritz ...
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2017, Vol.112, pp.164-176Elsevier
摘要:Abstract(#br)Although bacterial nanocellulose (BNC) has been widely investigated in the last 10 years as drug delivery system, up to now no long-term controlled release of drugs could be realized. Therefore, the aim of the present work was the development of a BNC-based drug...
作者:Carla Serri , Bruno de Gennaro , Vincenzo Quagliariello ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2017, Vol.99, pp.202-208Elsevier
摘要:Abstract(#br)In this study, a granulate for the oral controlled delivery of diclofenac sodium (DS), an anionic sparingly soluble nonsteroidal anti-inflammatory drug, has been realized by wet granulation, using a surface modified natural zeolite (SMNZ) as an excipient. The surface...
作者:Hoda Rabea , Ahmed M.A. Ali , Randa Salah Eldin ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2017, Vol.97, pp.182-191Elsevier
摘要:Abstract(#br)Substituting nebulisers by another in non-invasive ventilation circuit (NIV) involves many process variables which must be adjusted to ensure patient optimum therapy. However, there is a doubt when nebulisers use the same technology.(#br)Data mining technology based ...
作者:A.-C. Groo , M. De Pascale , A.-S. Voisin-Chiret ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2017, Vol.97, pp.218-226Elsevier
摘要:Abstract(#br)Pyridoclax is an original oligopyridine lead, very promising in treatment of chemoresistant cancers. However, from solubility measurement and permeability evaluation, it appeared that this compound can be considered as a BCS II drug, with a poor water solubility...
作者:Mayank Kumar Singh , Deep Pooja , Hitesh Kulhari ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2017, Vol.96, pp.84-92Elsevier
摘要:Abstract(#br)We present a dendrimer-based hybrid formulation strategy to explore the potential of poly (amidoamine) PAMAM dendrimers to be used as drug carriers for combination therapy of an anti-hypertensive drug ramipril (RAPL) and a diuretic hydrochlorothiazide (HCTZ). The dru...
作者:A. Kovács , Sz. Berkó , E. Csányi ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2017, Vol.99, pp.246-257Elsevier
摘要:Abstract(#br)The aim of our present work was to evaluate the applicability of the Quality by Design (QbD) methodology in the development and optimalization of nanostructured lipid carriers containing salicyclic acid (NLC SA). Within the Quality by Design methology, special e...
作者:E. Kaminska , O. Madejczyk , M. Tarnacka ...
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2017, Vol.113, pp.75-87Elsevier
摘要:Abstract(#br)Broadband dielectric spectroscopy (BDS) and differential scanning calorimetry (DSC) were applied to investigate the molecular dynamics and phase transitions in binary mixtures composed of naproxen (NAP) and acetylated saccharides: maltose (acMAL) and sucrose (acSUC)....

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