Elsevier期刊
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作者:Takayuki Yamamoto , Takahiro Shimoyama , Moeko Kuriyama
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.44, pp.69-73Elsevier
摘要:It is now widely acknowledged that the intestinal bacterial flora together with genetic predisposing factors significantly contribute to the immunopathogenesis of inflammatory bowel disease (IBD) as reflected by mucosal immune dysregulation. Recently, there has been an increased ...
作者:Travis S Bingeman , David H Perlman , Douglas G Storey ...
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.43, pp.134-140Elsevier
摘要:When cells mobilize nutrients from protein, they generate a fingerprint of peptide fragments that reflects the net action of proteases and the identities of the affected proteins. Analyzing these mixtures falls into a grey area between proteomics and metabolomics that is poorly s...
作者:Sergey Tumanov , Jurre J Kamphorst
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.43, pp.127-133Elsevier
摘要:The lipidome comprises a large array of molecules with diverse physicochemical properties. Lipids are structural components of cells, act as a source of energy, and function as signaling mediators. Alterations in lipid metabolism are involved in the onset and progression of ...
作者:An Nguyen , Simon A Rudge , Qifeng Zhang ...
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.43, pp.96-103Elsevier
摘要:Recent advances in lipidomics tools and software assist in the identification and quantification of lipid species detected by mass spectrometry. By integrating mass spectrometric lipid data into mapped pathways and databases, an entire network of lipid species which both demonstr...
作者:Marta W Vasconcelos , Wilhelm Gruissem , Navreet K Bhullar
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.44, pp.8-15Elsevier
摘要:Plant-based foods offer a wide range of nutrients that are essential for human and animal health. Among these nutrients, iron stands out as one of the most important micronutrients. Increasing the iron content in many staple and non-staple plant foods continues to be a goal of ma...
作者:Sara Glass , Jessica Fanzo
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.44, pp.46-51Elsevier
摘要:Genetically modified (GM) techniques to improve the nutrition and health content of foods is a highly debated area riddled with ethical dilemmas. Assessing GM technology with a public health ethical framework, this paper identifies public health goals, the potential burdens of th...
作者:Hamid R Eghbalnia , Pedro R Romero , William M Westler ...
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.43, pp.56-61Elsevier
摘要:The metabolome, the collection of small molecules associated with an organism, is a growing subject of inquiry, with the data utilized for data-intensive systems biology, disease diagnostics, biomarker discovery, and the broader characterization of small molecules in mixtures. Ow...
作者:Dana M Freund , Adrian D Hegeman
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.43, pp.41-48Elsevier
摘要:Methods employing isotope labeled compounds have been an important part of the bioanalytical canon for many decades. The past fifteen years have seen the development of many new approaches using stable (non-radioactive) isotopes as labels for high-throughput bioanalytical, ‘...
作者:Hamid Hamzeiy , Jürgen Cox
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.43, pp.141-146Elsevier
摘要:Computational workflows for mass spectrometry-based shotgun proteomics and untargeted metabolomics share many steps. Despite the similarities, untargeted metabolomics is lagging behind in terms of reliable fully automated quantitative data analysis. We argue that metabolomic...
作者:Ryo Nakabayashi , Kazuki Saito
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2017, Vol.43, pp.8-16Elsevier
摘要:The advent of the genome-editing era greatly increases the opportunities for synthetic biology research that aims to enhance production of potentially useful bioactive metabolites in heterologous hosts. A wide variety of sulfur (S)-containing metabolites (S-metabolites) are known...

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