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作者:Chitra D. Mandyam , Jan M. Schilling , Weihua Cui ...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (2), pp.101-110Elsevier
摘要:Abstract(#br)Background(#br)Studies in vitro demonstrate that neuronal membrane/lipid rafts (MLRs) establish cell polarity by clustering progrowth receptors and tethering cytoskeletal machinery necessary for neuronal sprouting. However, the effect of MLR and MLR-associated protei...
作者:Amy F.T. Arnsten , Ragy R. Girgis , David L. Gray ...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (1), pp.67-77Elsevier
摘要:Abstract(#br)Schizophrenia is characterized by profound cognitive deficits that are not alleviated by currently available medications. Many of these cognitive deficits involve dysfunction of the newly evolved, dorsolateral prefrontal cortex (dlPFC). The brains of patients with sc...
作者:Adarsh S. Reddy , David O’Brien , Nilambari Pisat ...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (3), pp.252-264Elsevier
摘要:Abstract(#br)Background(#br)Studies in psychiatric genetics have identified >100 loci associated with disease risk, yet many of these loci are distant from protein coding genes. Recent characterization of the transcriptional landscape of cell lines and whole tissues has sugg...
作者:Antonio Di Meco , Jian-Guo Li , Benjamin E. Blass ...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (2), pp.92-100Elsevier
摘要:ABSTRACT(#br)Background(#br)The 12/15-lipoxygenase (12/15-LO) enzyme is upregulated in the brains of patients with Alzheimer’s disease (AD), and its expression levels influence the onset of the AD-like phenotype in mouse models. However, whether targeting this pathway after ...
作者:Johnna R. Swartz , Rebecca Waller , Ryan Bogdan ...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (3), pp.203-210Elsevier
摘要:Abstract(#br)Background(#br)Williams syndrome (WS), a genetic disorder resulting from hemizygous microdeletion of chromosome 7q11.23, has emerged as a model for identifying the genetic architecture of socioemotional behavior. Common polymorphisms in GTF2I , which is found within ...
作者:Marija Kundakovic , Yan Jiang , David H. Kavanagh ...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (2), pp.162-170Elsevier
摘要:Abstract(#br)Background(#br)The nervous system may include more than 100 residue-specific posttranslational modifications of histones forming the nucleosome core that are often regulated in cell-type-specific manner. On a genome-wide scale, some of the histone posttranslational m...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (2), pp.A3-A4Elsevier
作者:Hannah Schoch , Arati S. Kreibich , Sarah L. Ferri ...
来源:[J].Biological Psychiatry(IF 9.247), 2017, Vol.81 (3), pp.193-202Elsevier
摘要:Abstract(#br)Background(#br)Behavioral symptoms in individuals with autism spectrum disorder (ASD) have been attributed to abnormal neuronal connectivity, but the molecular bases of these behavioral and brain phenotypes are largely unknown. Human genetic studies have implica...

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