PubMed期刊
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作者:Hondal Robert J , Ruggles Erik L
来源:[J].Amino Acids, 2010, Vol.41 (1), pp.73-89PubMed
摘要:This review covers three different chemical explanations that could account for the requirement of selenium in the form of selenocysteine in the active site of mammalian thioredoxin reductase. These views are the following: (1) the traditional view of selenocysteine as a superior...
作者:Zhou L , Liu S P , Chen L Y ...
来源:[J].Amino Acids, 2010, Vol.40 (1), pp.123-33PubMed
摘要:Understanding the molecular mechanisms of antimicrobial peptide-membrane interactions is crucial in predicting the design of useful synthetic antimicrobial peptide analogues. Defensins are small (3-5 kDa) cysteine-rich cationic proteins which constitute the front line of host inn...
作者:Rasmussen Bruce A , Baron David A , Kim Jae K ...
来源:[J].Amino Acids, 2010, Vol.40 (2), pp.761-4PubMed
摘要:We investigated the short- and long-term effects of ceftriaxone on glutamate transporter subtype 1 (GLT-1) transporter activity and extracellular glutamate in the rat nucleus accumbens. Repeated ceftriaxone administration (50, 100 or 200 mg/kg, i.p.) produced a dose-dependen...
作者:Pinto John T , Lee Jeong-In , Sinha Raghu ...
来源:[J].Amino Acids, 2010, Vol.41 (1), pp.29-41PubMed
摘要:Previous studies on the chemopreventive mechanisms of dietary selenium have focused on its incorporation into antioxidative selenoproteins, such as glutathione peroxidase and thioredoxin reductase. Several studies, however, have revealed that dietary selenium in the form of ...
作者:Schmidt Frank , Dahlmann Burkhardt , Hustoft Hanne K ...
来源:[J].Amino Acids, 2010, Vol.41 (2), pp.351-61PubMed
摘要:Regulated proteolysis plays important roles in cell biology and pathological conditions. A crosstalk exists between apoptosis and the ubiquitin-proteasome system, two pathways responsible for regulated proteolysis executed by different proteases. To investigate whether the a...
作者:Sikalidis Angelos K , Lee Jeong-In , Stipanuk Martha H
来源:[J].Amino Acids, 2010, Vol.41 (1), pp.159-71PubMed
摘要:The integrated stress response (ISR), a defense mechanism cells employ when under stress (e.g., amino acid deprivation), causes suppression of global protein synthesis along with the paradoxical increased expression of a host of proteins that are useful in combating various ...
作者:Sawada N , Nagahara N , Arisaka F ...
来源:[J].Amino Acids, 2010, Vol.41 (1), pp.173-80PubMed
摘要:The oligomeric state of human porphobilinogen synthase (PBGS) [EC.4.2.1.24] is homooctamer, which consists of conformationally heterogenous subunits in the tertiary structure under air-saturated conditions. When PBGS is activated by reducing agent with zinc ion, a reservoir zinc ...
作者:Meneses Erika P , Villa-Hernández Oscar , Hernández-Orihuela Lorena ...
来源:[J].Amino Acids, 2010, Vol.40 (1), pp.113-22PubMed
摘要:High-resolution mass spectrometry-based peptidomics has been used to characterize several components in electro-stimulated skin secretions of the endemic Mexican frog Pachymedusa dacnicolor. Peptide mass screening performed in an Orbitrap-XL mass spectrometer showed that P. dacni...
作者:Cooper Arthur J L , Krasnikov Boris F , Niatsetskaya Zoya V ...
来源:[J].Amino Acids, 2010, Vol.41 (1), pp.7-27PubMed
摘要:Cysteine S-conjugate β-lyases are pyridoxal 5'-phosphate-containing enzymes that catalyze β-elimination reactions with cysteine S-conjugates that possess a good leaving group in the β-position. The end products are aminoacrylate and a sulfur-containing fragment. The aminoacr...
作者:Corrales-Garcia L L , Possani L D , Corzo G
来源:[J].Amino Acids, 2010, Vol.40 (1), pp.5-13PubMed
摘要:Human beta-defensins are 2-5 kDa, cationic, microbicidal peptides, which represent the first-line host defense against several Gram-negative and Gram-positive bacteria, fungi and viruses. They contain a conserved disulfide-bridge pattern of three pairs of intramolecular cystine b...

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