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作者:... Maturana Patricio , Puente Javier , Wolf Marion E
来源:[J].American Journal of Therapeutics, 2012, Vol.19 (3), pp.174-9PubMed
摘要:Results from a longitudinal study (blood drawn at days 29, 64, 89,124, 142, and 182 of the protocol) shows that the concentration of platelet-poor plasma (PPP) methionine(5)-enkephalin (MET) in healthy, drug-free, white male individuals (n = 5) remains within a relatively na...
作者:... Jara Pablo , Wolf Marion E , Mosnaim Aron D
来源:[J].Research Communications in Molecular Pathology and Pharmacology, 2003, Vol.111 (1-4), pp.3-12PubMed
摘要:Peripheral blood mononuclear cell (PBMC) cytotoxicity against S. typhi (wild type or mutant strain TYT1231)-infected U937 cells was significantly higher than its lytic effect against noninfected cells (control) at the various effector-to-target cell ratio used (30:1, 50:1 and 70:...
作者:... Ranade Vasant , Hoang Catherine , Wolf Marion E
来源:[J].American Journal of Therapeutics(IF 1.29), 2004, Vol.11 (6), pp.459-65PubMed
摘要:We identified a number of clinically used drugs and biologically active endogenous peptides able to significantly decrease the rate of human plasmatic aminopeptidase (AP) leucine-enkephalin (LEU) degradation. Bacitracin, bestatin, fluvoxamine, and each of 4 peptides tested signif...
作者:... Saavedra Rolando , Diamond Seymour , Wolf Marion E
来源:[J].Pharmacology(IF 1.603), 2002, Vol.67 (1), pp.6-13PubMed
摘要:A number of drugs with the phenothiazine molecule in their chemical structure inhibit in a dose-dependent manner human plasmatic aminopeptidase leucine(5)-enkephalin (LEU) metabolism. Half-life peptide degradation was significantly increased by thioridazine > fluphenazine > As-13...
作者:... Jara Pablo , Wolf Marion E , Mosnaim Aron D
来源:[J].American Journal of Therapeutics(IF 1.29), 2003, Vol.10 (1), pp.32-9PubMed
摘要:We examined the effect of Salmonella typhi (wild-type Ty2 and mutant strain TYT1231)-infected U937 cells on natural killer cell (NKC) cytotoxicity of peripheral blood mononuclear cells (PBMCs) and highly purified NKC (HPNKCs; CD16(+)/CD56(+) > 95%; the rest corresponding to CD3(+...
作者:... Abiola Rasheed , Wolf Marion E , Perlmuter Lawrence C
来源:[J].American Journal of Therapeutics, 2009, Vol.17 (1), pp.86-91PubMed
摘要:Orthostatic hypotension (OH) is regarded as a decrease primarily in systolic blood pressure on changing position from supine to erect. Based on clinical criteria, it is characterized by a decrease in systolic pressure of 20 mmHg and diastolic pressure of 10 mmHg within 1 to 3 min...
作者:... Puente Javier , Couceyro Pastor , Wolf Marion E
来源:[J].Neurochemical Research(IF 2.125), 2008, Vol.33 (1), pp.81-6PubMed
摘要:Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is...
作者:... Nguyen Tao D , Puente Javier , Wolf Marion E
来源:[J].American Journal of Therapeutics, 2008, Vol.15 (2), pp.126-30PubMed
摘要:After 10-minute incubation of [3H]-tyrosine methionine-enkephalin (MET) with 100,000 x g supernatant from select brain regions of patients with chronic schizophrenia (n = 3), essentially all of the labeled tyrosine was recovered as the free amino acid. Initial velocity and half-l...
作者:Wolf Marion E , Puente Javier
来源:[J].American Journal of Therapeutics(IF 1.29), 2006, Vol.13 (3), pp.261-73PubMed
摘要:The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, methylpiperazine, piperazine-ethanol, piperazine-ethyl, or pip...

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