作者:... Abiola Rasheed , Wolf Marion E , Perlmuter Lawrence C
来源:[J].American Journal of Therapeutics, 2009, Vol.17 (1), pp.86-91PubMed
摘要:Orthostatic hypotension (OH) is regarded as a decrease primarily in systolic blood pressure on changing position from supine to erect. Based on clinical criteria, it is characterized by a decrease in systolic pressure of 20 mmHg and diastolic pressure of 10 mmHg within 1 to 3 min...
作者:... Puente Javier , Couceyro Pastor , Wolf Marion E
来源:[J].Neurochemical Research(IF 2.125), 2008, Vol.33 (1), pp.81-6PubMed
摘要:Incubation of [3H]-tyrosine methionine5-enkephalin (MET) with human brain preparations (100,000g supernatant; sections of the limbic system, thalamus, basal ganglia, cerebellum, and cortex) results in its rapid and complete degradation; over 95% of the initial labeled tyrosine is...
作者:... Nguyen Tao D , Puente Javier , Wolf Marion E
来源:[J].American Journal of Therapeutics, 2008, Vol.15 (2), pp.126-30PubMed
摘要:After 10-minute incubation of [3H]-tyrosine methionine-enkephalin (MET) with 100,000 x g supernatant from select brain regions of patients with chronic schizophrenia (n = 3), essentially all of the labeled tyrosine was recovered as the free amino acid. Initial velocity and half-l...
作者:Wolf Marion E , Puente Javier
来源:[J].American Journal of Therapeutics(IF 1.29), 2006, Vol.13 (3), pp.261-73PubMed
摘要:The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, methylpiperazine, piperazine-ethanol, piperazine-ethyl, or pip...
作者:Wolf Marion E , Sadowski Laura S ...
来源:[J].Annals of Allergy, Asthma, & Immunology(IF 3.449), 2006, Vol.97 (4), pp.477-83PubMed
摘要:Little is known about how childhood asthma affects immigrant Hispanic families in the United States. Qualitative research is effective for understanding the social, cultural, functional, and structural aspects of asthma in the family context. Furthermore, such knowledge is necess...
作者:... Maturana Patricio , Puente Javier , Wolf Marion E
来源:[J].American Journal of Therapeutics, 2012, Vol.19 (3), pp.174-9PubMed
摘要:Results from a longitudinal study (blood drawn at days 29, 64, 89,124, 142, and 182 of the protocol) shows that the concentration of platelet-poor plasma (PPP) methionine(5)-enkephalin (MET) in healthy, drug-free, white male individuals (n = 5) remains within a relatively na...
作者:... Jara Pablo , Wolf Marion E , Mosnaim Aron D
来源:[J].Research Communications in Molecular Pathology and Pharmacology, 2003, Vol.111 (1-4), pp.3-12PubMed
摘要:Peripheral blood mononuclear cell (PBMC) cytotoxicity against S. typhi (wild type or mutant strain TYT1231)-infected U937 cells was significantly higher than its lytic effect against noninfected cells (control) at the various effector-to-target cell ratio used (30:1, 50:1 and 70:...
作者:... Ranade Vasant , Hoang Catherine , Wolf Marion E
来源:[J].American Journal of Therapeutics(IF 1.29), 2004, Vol.11 (6), pp.459-65PubMed
摘要:We identified a number of clinically used drugs and biologically active endogenous peptides able to significantly decrease the rate of human plasmatic aminopeptidase (AP) leucine-enkephalin (LEU) degradation. Bacitracin, bestatin, fluvoxamine, and each of 4 peptides tested signif...
作者:... Saavedra Rolando , Diamond Seymour , Wolf Marion E
来源:[J].Pharmacology(IF 1.603), 2002, Vol.67 (1), pp.6-13PubMed
摘要:A number of drugs with the phenothiazine molecule in their chemical structure inhibit in a dose-dependent manner human plasmatic aminopeptidase leucine(5)-enkephalin (LEU) metabolism. Half-life peptide degradation was significantly increased by thioridazine > fluphenazine > As-13...


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