PubMed期刊
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作者:Walker Michael P , Shpargel Karl B ...
来源:[J].The Journal of Cell Biology(IF 10.822), 2007, Vol.176 (6), pp.831-41PubMed
摘要:Mutations in human survival motor neurons 1 (SMN1) cause spinal muscular atrophy (SMA) and are associated with defects in assembly of small nuclear ribonucleoproteins (snRNPs) in vitro. However, the etiological link between snRNPs and SMA is unclear. We have developed a Drosophil...
作者:... Fleck Lois C , Moberg William K , Walker Michael P
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2005, Vol.435 (2), pp.280-90PubMed
摘要:Famoxadone (FAM) is a newly commercialized antibiotic for use against plant pathogenic fungi. It inhibits mitochondria ubiquinol:cytochrome c oxidoreductase (EC 1.10.2.2, bc(1) complex) function by binding to the proximal niche of the quinol oxidation site on the enzyme. FAM has ...
作者:... Mishina Yuji , Walker Michael P , DiAugustine Richard P
来源:[J].Molecular and Cellular Biology(IF 5.372), 2005, Vol.25 (12), pp.5270-81PubMed
摘要:Aurora A is a mitotic kinase that localizes to centrosomes. Expression of this protein is normally limited to the mitotic stage (G(2)-M) of the cell cycle, whereas human cancer cells frequently exhibit overexpression of Aurora A protein regardless of the cell cycle stage. In the ...
作者:... Klotz Diane M , Walker Michael P , Diaugustine Richard P
来源:[J].Endocrinology(IF 4.717), 2004, Vol.145 (7), pp.3106-10PubMed
摘要:The development of the mouse mammary gland occurs postnatally. Hormonal activation of local growth factor pathways stimulates rapid elongation and branching of the rudimentary gland through the fatty stroma. Earlier studies showed that GH is required for mammary gland ductal morp...
作者:Walker Michael P , Laferla Frank M ...
来源:[J].Age, 2013PubMed
摘要:With aging and Alzheimer's disease (AD), there is an increased sensitivity to stress along with declines in the memory-associated neurotrophin brain-derived neurotrophic factor in AD. We have replicated this aging phenotype in cultured neurons from aged mice despite being gr...
作者:Walker Michael P , Diaugustine Richard P ...
来源:[J].Journal of Endocrinology, 2010, Vol.207 (2), pp.225-35PubMed
摘要:Estrogens are potent mitogens for some target organs, such as the uterus, and cancers that develop in this organ might be linked to the proliferative action of these hormones. However, the mechanism by which estrogens influence the cell cycle machinery is not known. We found that...
作者:Walker Michael P , Tian Liping , Matera A Gregory
来源:[J].PL o S One(IF 3.73), 2009, Vol.4 (7), pp.e6171PubMed
摘要:Coilin is the signature protein of the Cajal body, a conserved nuclear organelle involved in multiple aspects of small ribonucleoprotein (RNP) biogenesis. Coilin is required for Cajal body homeostasis in both plants and animals. Mice lacking coilin are viable when the mutation is...
作者:Walker Michael P , Rajendra T K ...
来源:[J].Human Molecular Genetics, 2008, Vol.17 (21), pp.3399-410PubMed
摘要:Spinal muscular atrophy (SMA) is a recessive neuromuscular disease caused by mutations in the human survival motor neuron 1 (SMN1) gene. The human SMN protein is part of a large macromolecular complex involved in the biogenesis of small ribonucleoproteins. Previously, we showed t...

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