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作者:Bashar Adi Wahyu Pandhita , Vivian Soetikno , Melva Louisa
来源:[J].International Journal of Applied Pharmaceutics, 2018, Vol.10 (1), pp.152-154IAS
摘要:Objective: This study aimed to investigate the effect of nanocurcumin (NC) against cisplatin-induced acute kidney injury, focusing on Nrf2 and Keap1.Methods: Male Sprague-Dawley rats (n=23) were divided into five groups (Control, CP, CP+Cur, CP+50 NC, and CP+100 NC) and sacrifice...
作者:Deliana Nur Ihsani Rahmi , Melva Louisa , Vivian Soetikno
来源:[J].International Journal of Applied Pharmaceutics, 2018, Vol.10 (1), pp.172-174IAS
摘要:Objective: This study aimed to investigate the efficacy of curcumin (CMN) and nanocurcumin (NC) at preventing cisplatin (CDPP)-inducednephrotoxicity.Methods: Two membrane transporters, copper transporter 1 (CTR1) and organic cation transporter 2 (OCT2), have been identified invol...
作者:... PURWANTYASTUTI . , MEANALDI RASMIN , VIVIAN SOETIKNO
来源:[J].International Journal of Applied Pharmaceutics, 2019, pp.272-276IAS
摘要:Objective: Appropriate tuberculosis (TB) treatment guidelines are one of the many factors that influence the success of TB treatment. The patient’sdrug supervisor is a functional role that is part of the directly observed treatment short course, a program to support the succ...
作者:... KELVIN THEANDRO GOTAMA , VIVIAN SOETIKNO , MELVA LOUISA
来源:[J].International Journal of Applied Pharmaceutics, 2019, pp.164-167IAS
摘要:Objective: Alcohol accumulation in the liver can cause pathological disorders such as liver fibrosis that can develop into hepatocellular carcinoma,one of the main causes of mortality associated with liver disease. The previous studies have shown that a plant compound, alpha...
作者:... YUYUNTIA YUYUNTIA , VIVIAN SOETIKNO , MELVA LOUISA
来源:[J].International Journal of Applied Pharmaceutics, 2019, pp.177-180IAS
摘要:Objective: Alpha-mangostin (α-MG) has been shown to possess antifibrotic effects. However, the specific mechanism of action of this compoundremains poorly understood. Therefore, the aim of this study was to investigate the effect of α-MG on the expression levels of transform...
作者:... MELVA LOUISA , BANTARI WK WARDHANI , VIVIAN SOETIKNO
来源:[J].International Journal of Applied Pharmaceutics, 2019, pp.168-171IAS
摘要:Objectives: In various liver disease models, including those for alcoholic liver diseases, curcumin, a polyphenolic compound derived fromCurcuma longa, is known to have an hepatoprotective effect. However, the mechanism of action underlying its effects on alcohol-induced hep...
作者:VIVIAN SOETIKNO , MELVA LOUISA
来源:[J].International Journal of Applied Pharmaceutics, 2019, pp.230-233IAS
摘要:Objective: The antineoplastic agent doxorubicin (DOX) is known for causing liver toxicity. Its metabolism in hepatocytes causes oxidative stress, which,in turn, induces DNA damage, lipid peroxidation, ATP depletion, and apoptosis. L-citrulline (CIT), a commonly found agent i...

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