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作者:Tom Coenye , Paola Brocca ...
来源:[J].Nanomedicine: Nanotechnology, Biology, and Medicine(IF 6.93), 2020, Vol.23
摘要:Abstract(#br)C109 is a potent but poorly soluble FtsZ inhibitor displaying promising activity against Burkholderia cenocepacia , a high-risk pathogen for cystic fibrosis ( CF ) sufferers. To harness C109 for inhalation, we developed nanocrystal-embedded dry powders for inhal...
作者:Tom Coenye , Pascal Van Der Voort ...
来源:[J].Applied Surface Science(IF 2.112), 2020, Vol.500
摘要:Abstract(#br)The objective of this study was the development of Ag-rich antibacterial coatings on titanium to prevent post-operative infections. A series of Ag-doped TiO 2 coatings were synthesized on Ti discs by plasma electrolytic oxidation in an electrolyte containing AgNPs. T...
作者:Tom Coenye , Lhousseine Touqui
来源:[J].Journal of Cystic Fibrosis(IF 2.873), 2020, Vol.19 (Supl.1), pp.S47-S53
摘要:Abstract(#br)The respiratory tract of individuals with cystic fibrosis is host to polymicrobial infections that persist for decades and lead to significant morbidity and mortality. Improving our understanding of CF respiratory infections requires coordinated efforts from research...
作者:... Christian Gorzelanny , Tom Coenye , Peter Dubruel
来源:[J].Carbohydrate Polymers(IF 3.479), 2018, Vol.191, pp.127-135
摘要:Abstract(#br)Tissue engineering (TE) approaches often employ polymer-based scaffolds to provide support with a view to the improved regeneration of damaged tissues. The aim of this research was to develop a surface modification method for introducing chitosan as an antibacte...
作者:Tom Coenye , José C. Martins ...
来源:[J].BBA - Biomembranes(IF 3.389), 2017, Vol.1859 (3), pp.331-339
摘要:Abstract(#br)Many Pseudomonas spp. produce cyclic lipodepsipeptides (CLPs), which, besides their role in biological functions such as motility, biofilm formation and interspecies interactions, are antimicrobial. It has been established that interaction with the cellular membrane ...
作者:Tom Coenye , Rino Morent ...
来源:[J].Materials Letters(IF 2.224), 2017, Vol.196, pp.213-216
摘要:Abstract(#br)Coating biomedical implant surfaces with biopolymers is an easy and inexpensive way to impart functionalities. Numerous biocompatible biopolymers, including cationic crustacean-derived chitosans, have been used. Here, substrates of Titanium (Ti), commonly used for bo...
作者:Tom Coenye , Wim Martinet ...
来源:[J].Journal of Microbiological Methods(IF 2.161), 2017, Vol.139, pp.181-188
摘要:Abstract(#br)Several B. cenocepacia mouse models are available to study the pulmonary infection by this Burkholderia cepacia complex (BCC) species. However, a characterized B. cenocepacia mouse model to evaluate the efficacy of potential new antibacterial therapies is not yet des...
作者:... Peter Østrup Jensen , Thomas Bjarnsholt , Tom Coenye
来源:[J].Trends in Microbiology(IF 8.434), 2019, Vol.27 (10), pp.850-863
摘要:Active bacterial metabolism is a prerequisite for optimal activity of many classes of antibiotics. Hence, bacteria have developed strategies to reduce or modulate metabolic pathways to become tolerant. This review describes the tight relationship between metabolism and toler...
作者:Tom Coenye , Valérie Vanhoorne ...
来源:[J].Carbohydrate Polymers(IF 3.479), 2019, Vol.205, pp.427-436
摘要:Abstract(#br)The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle f...
作者:Karl-Jan Spittaels , Tom Coenye
来源:[J].Anaerobe(IF 2.022), 2018, Vol.49, pp.21-29
摘要:Abstract(#br)Aim(#br)The aim of the present study was to develop a new model system to study Propionibacterium acnes biofilms. This model should be representative for the conditions encountered in the pilosebaceous unit.(#br)Methods and results(#br)The new model, consists of an a...

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