Wiley期刊
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作者:Thomas P. Johnston , Giuseppe Derosa ...
来源:[J].Journal of Cellular Physiology(IF 4.218), 2017, Vol.232 (7), pp.1660-1668Wiley
摘要:Exosomes are naturally occurring extracellular vesicles released by most mammalian cells in all body fluids. Exosomes are known as key mediators in cell‐cell communication and facilitate the transfer of genetic and biochemical information between distant cells. Structurally,...
作者:... Matteo Pirro , Thomas P. Johnston , Amirhosein Sahebkar
来源:[J].BioFactors(IF 3.088), 2017, Vol.43 (3), pp.331-346Wiley
摘要:Abstract(#br)Curcumin, the bioactive polyphenolic ingredient of turmeric, has been extensively studied for its effects on human papilloma virus (HPV) infection as well as primary and malignant squamous cervical cancers. HPV infections, especially those related to HPV 16 and ...
作者:Thomas P. Johnston , Alexander P. Lykov ...
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2016, Vol.68 (12), pp.1516-1526Wiley
摘要:Abstract(#br)Objectives(#br)We evaluated the hypolipidaemic effect of mannan Candida albicans serotype A, relative to atorvastatin, in a mouse model of hyperlipidaemia.(#br)Methods(#br)Mannan serotype A was investigated in vitro and in vivo to determine its effects on macrop...
作者:Thomas P. Johnston , Masakazu Shinohara ...
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2012, Vol.64 (5), pp.677-687Wiley
摘要:Abstract(#br)Objectives There is an inverse relationship between high‐density lipoprotein (HDL) and heart disease. HDL possesses not only both antioxidant and anti‐inflammatory properties, but also anti‐thrombotic and endothelial function‐promoting qualities. However, i...
作者:Thomas P. Johnston , David J. Waxman
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2008, Vol.60 (6), pp.753-759Wiley
摘要:Abstract(#br)The copolymer surfactant poloxamer 407 (P‐407) has been used to induce a dose‐controlled dyslipidaemia in both mice and rats. Human macrophages cultured with P‐407 exhibit a concentration‐dependent reduction in cholesterol efflux to apolipoprotein A1 (apoA1...
作者:Thomas P. Johnston , Kamesh R. Kuchimanchi ...
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2003, Vol.55 (8), pp.1083-1090Wiley
摘要:Abstract(#br)The aim of our study was to induce changes in the plasma elimination half‐life (t1/2 elim), rate and extent of urinary excretion, and biodistribution of a model macromolecule, poly‐l‐lysine, in rats following complexation with heparin. Male Sprag...
作者:Thomas P. Johnston , Ira J. Goldberg
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2006, Vol.58 (8), pp.1099-1105Wiley
摘要:Abstract(#br)This investigation was conducted to evaluate whether poloxamer 407 (P‐407), a nonionic surface‐active‐agent that functions as a lipase inhibitor, could aid in weight loss by inactivating pancreatic lipase (PL) following oral administration to mice. Using a ...
作者:Thomas P. Johnston
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2010, Vol.62 (12), pp.1807-1812Wiley
摘要:Abstract(#br)Objectives The aims of this investigation were to determine if the activity of endothelial lipase was inhibited in vitro by the polymeric surfactant, poloxamer 407 (P‐407), and to review the action of P‐407 on the biological activity of several other critical li...
作者:... Hemant H. Alur , Ashim K. Mitra , Thomas P. Johnston
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2002, Vol.54 (3), pp.315-323Wiley
摘要:Abstract(#br)Low oral bioavailability of therapeutic peptides and proteins generally results from their poor permeability through biological membranes and enzymatic degradation in the gastrointestinal tract. Since different secondary structures exhibit different physicochemi...
作者:... David G. Vander Velde , Ashim K. Mitra , Thomas P. Johnston
来源:[J].Journal of Pharmacy and Pharmacology(IF 2.033), 2002, Vol.54 (11), pp.1497-1505Wiley
摘要:Abstract(#br)Peptide drugs are hydrophilic in nature and so their preferred pathway of membrane transport is by the paracellular route, which primarily involves passive diffusion across intercellular pores. The objective of the present study was to investigate the effect of ...

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