作者:... Nicole J. Darling , Weixian Xi , Tatiana Segura
来源:[J].Acta Biomaterialia(IF 5.093), 2019, Vol.94, pp.160-172Elsevier
摘要:Abstract(#br)Designing scaffolds for polyplex-mediated therapeutic gene delivery has a number of applications in regenerative medicine, such as for tissue repair after wounding or disease. Microporous annealed particle (MAP) hydrogels are an emerging class of porous biomaterials,...
作者:... Yiu-Sun Hung , Shruti Sharma , Tatiana Segura
来源:[J].Biomaterials(IF 7.604), 2016, Vol.101, pp.199-206Elsevier
摘要:Abstract(#br)The development of synthetic hydrogels analogs for the extracellular matrix has proven a useful and important tool to study the role of specific signals on biological outcomes in vitro and to serve as scaffolds for tissue repair. Although the importance of physical p...
作者:Jonathan Lam , Norman F. Truong , Tatiana Segura
来源:[J].Acta Biomaterialia(IF 5.093), 2014, Vol.10 (4), pp.1571-1580Elsevier
摘要:Abstract(#br)The design of hyaluronic acid (HA)-based hydrogel scaffolds to elicit highly controlled and tunable cell response and behavior is a major field of interest in developing tissue engineering and regenerative medicine applications. This review will begin with an ov...
作者:... William E. Lowry , Tatiana Segura , S. Thomas Carmichael
来源:[J].Biomaterials(IF 7.604), 2016, Vol.105, pp.145-155Elsevier
摘要:Abstract(#br)Stem cell therapies have shown promise in promoting recovery in stroke but have been limited by poor cell survival and differentiation. We have developed a hyaluronic acid (HA)-based self-polymerizing hydrogel that serves as a platform for adhesion of structural moti...
作者:Talar Tokatlian , Cynthia Cam , Tatiana Segura
来源:[J].Biomaterials(IF 7.604), 2014, Vol.35 (2), pp.825-835Elsevier
摘要:Abstract(#br)The lack of vascularization within tissue-engineered constructs remains the primary cause of construct failure following implantation. Porous constructs have been successful in allowing for vessel infiltration without requiring extensive matrix degradation. We h...
作者:Cynthia Cam , Tatiana Segura
来源:[J].Acta Biomaterialia(IF 5.093), 2014, Vol.10 (1), pp.205-213Elsevier
摘要:Abstract(#br)The implantation of scaffolds for tissue repair has achieved only limited success due primarily to the inability to achieve vascularization within the construct. Many strategies have therefore moved to incorporate pores into the scaffolds to encourage rapid cellular ...
作者:Shayne Siegman , Norman F. Truong , Tatiana Segura
来源:[J].Acta Biomaterialia(IF 5.093), 2015, Vol.28, pp.45-54Elsevier
摘要:Abstract(#br)The effective delivery of DNA locally could increase the applicability of gene therapy in tissue regeneration and therapeutic angiogenesis. One promising approach is through use of porous hydrogel scaffolds that incorporate and deliver DNA in the form of nanopar...
作者:Jonathan Lam , Tatiana Segura
来源:[J].Biomaterials(IF 7.604), 2013, Vol.34 (16), pp.3938-3947Elsevier
摘要:Abstract(#br)Biomaterials designed to mimic the intricate native extracellular matrix (ECM) can use a variety of techniques to control the behavior of encapsulated cells. Common methods include controlling the mechanical properties of the material, incorporating bioactive signals...
作者:... Shayne N. Siegman , Yuguo Lei , Tatiana Segura
来源:[J].Acta Biomaterialia(IF 5.093), 2012, Vol.8 (11), pp.3921-3931Elsevier
摘要:Abstract(#br)The effective and sustained delivery of DNA locally could increase the applicability of gene therapy in tissue regeneration and therapeutic angiogenesis. One promising approach is to use porous hydrogel scaffolds to encapsulate and deliver nucleotides in the for...


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