印度尼西亚医学期刊
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作者:... Indra G. Mansur , Sri W.A. Jusman , Mohamad Sadikin
来源:[J].Medical Journal of Indonesia, 2016, Vol.25 (1), pp.19-24Medical Journal of Indonesia
摘要:Background: Cell proliferation occurs not only in normal but also in cancer cells. Most of cell proliferation inhibition can be done by inhibiting the DNA synthesis, notably by intervening the formation of purine or pyrimidine. In purine de novo synthesis, it was assumed that bio...
作者:... Ani R. Prijanti , Sri W.A. Jusman , Mohamad Sadikin
来源:[J].Medical Journal of Indonesia, 2016, Vol.25 (1), pp.3-9Medical Journal of Indonesia
摘要:Background: Urea biosynthesis is a very important process in the liver which needs ATP, CO2 and functional mitochondria or aerobic condition. Liver can adapt to hypoxic condition, generally and locally. This study aimed to analyze the effect of chronic hypoxia on liver...
作者:... Arleni Arleni , Sri W.A. Jusman , Franciscus D. Suyatna
来源:[J].Medical Journal of Indonesia, 2012, Vol.21 (1)Medical Journal of Indonesia
摘要:Background: Concomitant treatment with antimalaria and antiretroviral drug is a new challenge in the management of malaria and HIV co-infection. Primaquine is a substrate and also an inhibitor of CYP3A4, while ritonavir is a substrate, an inhibitor, and also an inducer for C...
作者:Andi N.K. Syarifin , Sri W.A. Jusman , Mohamad Sadikin
来源:[J].Medical Journal of Indonesia, 2015, Vol.24 (3), pp.139-45Medical Journal of Indonesia
摘要:Background: Hypoxia can cause acidosis. Kidney plays an essential role in maintaining acid-base balance, which involves the activities of carbonic anhydrase (CA) and glutaminase (GLS). This study is aimed to determine the expression and activities of the CA9 and GLS1 enzymes...
作者:Ulfah Lutfiah , Sri W.A. Jusman , Mochammad Sadikin
来源:[J].Medical Journal of Indonesia, 2015, Vol.24 (3), pp.133-8Medical Journal of Indonesia
摘要:Background: Hypoxia may induce gastric ulcer associated with excessive hidrogen chloride (HCl) secretion. Synthesis of HCl involves 2 enzymes, H,K-ATPase and carbonic anhydrase (CA). This study aimed to clarify the underlying cause of gastric ulcer in chronic hypoxic condition, b...
作者:... Mohamad Sadikin , Septelia I. Wanandi , Sri W.A. Jusman
来源:[J].Medical Journal of Indonesia, 2018, Vol.27;;27;;27 (4;;3;;2;;1), pp.145-9Medical Journal of Indonesia
摘要:Background: Keloid is an abnormal wound healing process that extends beyond the site of injury. Keloid and tumor’s shared similarity of recurrence suggesting a shared underlying mechanism that involves stemness. Octamer-binding transcription factor-4 (Oct-4) and aldehyde deh...
作者:... Ani R. Prijanti , Sri W.A. Jusman , Mohamad Sadikin
来源:[J].Medical Journal of Indonesia, 2018, Vol.27;;27;;27 (4;;3;;2;;1), pp.223-8Medical Journal of Indonesia
摘要:Background: Lymphocytes activated by immunization must increase their metabolism to meet the energy requirements for mitosis, differentiation, and protein synthesis, which may subject the cell to conditions of relative hypoxia and oxidative stress. This study was conducted t...
作者:Sri W.A. Jusman , Frans Ferdinal ...
来源:[J].Medical Journal of Indonesia, 2009, Vol.18 (2)Medical Journal of Indonesia
摘要:Aim This study explored the expression of HIF-1α in hypoxic cardiac muscle in mice, and observed the evidence of apoptosis in hypoxia induced cardiomyocyte.Methods Male Sprague-Dawley rats, were randomized into 7 groups (n = 4 per group): control normoxia group that was exp...
作者:... Frans D. Suyatna , Arini Setiawati , Sri W.A. Jusman
来源:[J].Medical Journal of Indonesia, 2009, Vol.18 (4)Medical Journal of Indonesia
摘要:Aim: Some carotenoids such as canthaxantin, astaxanthin and beta apo-8’-carotenal were reported to have modulatoryeffect on the cytochrome P450. The present study was conducted to investigate the effects of lycopene, a nonprovitamin A carotenoid, on microsomal cytochr...
作者:... Syarifah Dewi , Sri W.A. Jusman , Mohamad Sadikin
来源:[J].Medical Journal of Indonesia, 2010, Vol.20 (1)Medical Journal of Indonesia
摘要:Background: Hypoxia results in an increased generation of ROS. Until now, little is known about the role of MnSOD - a major endogenous antioxidant enzyme - on the cell adaptation response against hypoxia. The aim of this study was to determine the MnSOD mRNA expression and ...

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