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作者:Sim Yun-Beom , Lee Jin-Koo ...
来源:[J].Archives of pharmacal research(IF 1.538), 2016, Vol.39 (5), pp.660-7PubMed
摘要:In the present study, we characterized the expression and role of forkhead box O (FoxO3a) in kainic acid (KA)-induced hippocampal neuronal cell death. FoxO3a and pFoxO3a expression in the CA1, CA2, and dentate gyrus regions in the hippocampus increased 0.5 and 1 h after intr...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology(IF 1), 2016, Vol.20 (5), pp.467-76PubMed
摘要:In the present study, we examined the effect of pertussis toxin (PTX) administered centrally in a variety of stress-induced blood glucose level. Mice were exposed to stress after the pretreatment of PTX (0.05 or 0.1 µg) i.c.v. or i.t. once for 6 days. Blood glucose level was...
作者:Sim Yun-Beom , Kim Sung-Su ...
来源:[J].The Chinese journal of physiology(IF 0.748), 2017, Vol.60 (1)PubMed
摘要:Kainic acid (KA) is a well-known excitatory neurotoxic substance. In the present study, effectsof KA-injected intraperitoneally (i.p.), intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on theblood glucose level were investigated in ICR mice. We found that KA administere...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].Pharmacology, Biochemistry and Behavior, 2012, Vol.102 (1), pp.170-6PubMed
摘要:The relationship between interleukin-1β (IL-1β)-induced nociception and the blood glucose level was studied in ICR mice. We found in the present study that intrathecal (i.t.) injection of IL-1β increased pain behavior. In addition, i.t. IL-1β injection caused an elevation of...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].Archives of Pharmacal Research(IF 1.538), 2010, Vol.33 (10), pp.1679-83PubMed
摘要:This study was done to determine the effect of stress on blood glucose regulation in ICR mice. The stress was induced by the electrical foot shock-witness model. Blood glucose level was found to be increased in the electrical foot shock-induced physical stress group. Further...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].Neuroscience letters, 2012, Vol.528 (1), pp.73-7PubMed
摘要:In the present study, the possible anti-diabetic action of biguanide and thiazolidinediones administered supraspinally or spinally was studied in ICR mice.;;Mice were intracerebroventricular (i.c.v.) or intrathecal (i.t.) treated with 20 or 30 μg metformin, pioglitazone and ...
作者:Sim Yun-Beom , Kang Yu-Jung ...
来源:[J].Korean Journal of Physiology and Pharmacology(IF 1), 2012, Vol.16 (2), pp.119-23PubMed
摘要:In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Agr...
作者:... Jung Jun-Sub , Sim Yun-Beom , Suh Hong-Won
来源:[J].Archives of Pharmacal Research(IF 1.538), 2011, Vol.34 (2), pp.269-80PubMed
摘要:We have evaluated the possible underlying mechanisms of immobilization stress-induced analgesia (SIA) by behavioral cross-tolerance studies and molecular studies. In the behavioral studies, the cross-tolerance between single or repeated immobilization SIA and the antinocicep...
作者:Sim Yun-Beom , Lee Jin-Koo ...
来源:[J].Archives of Pharmacal Research(IF 1.538), 2011, Vol.34 (3), pp.501-7PubMed
摘要:In the present study, the antinociceptive profiles of eugenol were examined in ICR mice. Eugenol administered orally (from 1 to 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. Duration of antinocicep...
作者:Sim Yun-Beom , Kang Yu-Jung ...
来源:[J].Neuroscience letters, 2010, Vol.476 (3), pp.119-22PubMed
摘要:The regulation of blood glucose level in intracerebroventricular (i.c.v.) administration with opioid alone or opioid withdrawal model was studied in ICR mice. In the first group, we found that i.c.v. administered morphine or beta-endorphin alone causes an elevation of blood gluco...

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