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作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology(IF 1), 2016, Vol.20 (1), pp.83-9PubMed
摘要:Sepsis is the life-threatening response to infection which can lead to tissue damage, organ failure, and death. In the current study, the effect of orally administered D-glucose on the mortality and the blood glucose level induced by D-Galactosamine (GaLN)/lipopolysaccharide...
作者:Sim Yun-Beom , Lee Jin-Koo ...
来源:[J].Archives of pharmacal research(IF 1.538), 2016, Vol.39 (5), pp.660-7PubMed
摘要:In the present study, we characterized the expression and role of forkhead box O (FoxO3a) in kainic acid (KA)-induced hippocampal neuronal cell death. FoxO3a and pFoxO3a expression in the CA1, CA2, and dentate gyrus regions in the hippocampus increased 0.5 and 1 h after intr...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology(IF 1), 2016, Vol.20 (5), pp.467-76PubMed
摘要:In the present study, we examined the effect of pertussis toxin (PTX) administered centrally in a variety of stress-induced blood glucose level. Mice were exposed to stress after the pretreatment of PTX (0.05 or 0.1 µg) i.c.v. or i.t. once for 6 days. Blood glucose level was...
作者:Sim Yun-Beom , Kim Sung-Su ...
来源:[J].The Chinese journal of physiology(IF 0.748), 2017, Vol.60 (1)PubMed
摘要:Kainic acid (KA) is a well-known excitatory neurotoxic substance. In the present study, effectsof KA-injected intraperitoneally (i.p.), intracerebroventricularly (i.c.v.) or intrathecally (i.t.) on theblood glucose level were investigated in ICR mice. We found that KA administere...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology(IF 1), 2013, Vol.17 (2), pp.163-7PubMed
摘要:In the present study, the effect of intrathecal (i.t.) or intracerebroventricular (i.c.v.) administration with cholera toxin (CTX) on the blood glucose level was examined in ICR mice. The i.t. treatment with CTX alone for 24 h dose-dependently increased the blood glucose level. H...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology(IF 1), 2014, Vol.17 (6), pp.493-7PubMed
摘要:We have recently demonstrated that some anti-diabetic drugs such as biguanide and thizolidinediones administered centrally modulate the blood glucose level, suggesting that orally administered anti-diabetic drugs may modulate the blood glucose level by acting on central nerv...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology(IF 1), 2014, Vol.18 (1), pp.41-6PubMed
摘要:The possible roles of spinal histamine receptors in the regulation of the blood glucose level were studied in ICR mice. Mice were intrathecally (i.t.) treated with histamine 1 (H1) receptor agonist (2-pyridylethylamine) or antagonist (cetirizine), histamine 2 (H2) receptor a...
作者:Sim Yun-Beom , Kang Yu-Jung ...
来源:[J].Archives of pharmacal research(IF 1.538), 2013, Vol.36 (7), pp.905-11PubMed
摘要:The antinociceptive effects of oleanolic acid were examined in ICR mice. Oleanolic acid administered orally (1, 5 and 10 mg/kg) showed an antinociceptive effect in a dose-dependent manner as measured in the acetic acid-induced writhing test. In the time- course study, durati...
作者:Sim Yun-Beom , Park Soo-Hyun ...
来源:[J].Archives of pharmacal research(IF 1.538), 2015, Vol.38 (5), pp.921-9PubMed
摘要:The blood glucose profiles were characterized after mice were forced into immobilization stress with various exposure durations. The blood glucose level was significantly enhanced by immobilization stress for 30 min or 1 h, respectively. On the other hand, the blood glucose ...
作者:Sim Yun-Beom , Jung Jun-Sub
来源:[J].The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology(IF 1), 2011, Vol.15 (5), pp.251-8PubMed
摘要:Here we have investigated how lactosylceramide (LacCer) modulates gene expression of adhesion molecules in TNF-α and IFNγ (CM)-stimulated astrocytes. We have observed that stimulation of astrocytes with CM increased the gene expression of ICAM-1 and VCAM-1. D-Threo-1-phenyl-...

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