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作者:Rozhin Penjweini , Alessio Andreoni ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2018, Vol.23 (10), pp.107001-107001SPIE
摘要:Oxygen (O2) is one of the most important biometabolites. In abundance, it serves as the limiting terminus of aerobic respiratory chains in the mitochondria of higher organisms; in deficit, it is a potent determinant of development and regulation of other physiological ...
作者:Michele M. Kim , Rozhin Penjweini , Timothy C. Zhu
来源:[J].Journal of Biomedical Optics(IF 2.881), 2017, Vol.22 (2), pp.028002-028002SPIE
摘要:Existing dosimetric quantities do not fully account for the dynamic interactions between the key components of photodynamic therapy (PDT) or the varying PDT oxygen consumption rates for different fluence rates. Using a macroscopic model, reacted singlet oxygen ( [ O 2 ...
作者:Rozhin Penjweini , Baochang Liu ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2015, Vol.20 (12), pp.128003-128003SPIE
摘要:Type II photodynamic therapy (PDT) is based on the photochemical reactions mediated through an interaction between a photosensitizer, ground-state oxygen ( [ O 3 2 ] ), and light excitation at an appropriate wavelength, which results in production of...
作者:Timothy C. Zhu , Baochang Liu , Rozhin Penjweini
来源:[J].Journal of Biomedical Optics(IF 2.881), 2015, Vol.20 (3), pp.038001-038001SPIE
摘要:An appropriate expression for the oxygen supply rate ( Γ s ) is required for the macroscopic modeling of the complex mechanisms of photodynamic therapy (PDT). It is unrealistic to model the actual heterogeneous tumor microvascular networks coupled with the PDT processes beca...
作者:... Michele M. Kim , Rozhin Penjweini , Timothy C. Zhu
来源:[J].Journal of Biomedical Optics(IF 2.881), 2016, Vol.21 (8), pp.088002-088002SPIE
摘要:Although photodynamic therapy (PDT) is an established modality for cancer treatment, current dosimetric quantities, such as light fluence and PDT dose, do not account for the differences in PDT oxygen consumption for different fluence rates ( φ ). A macroscopic model was ado...

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