European Cells and Materials (eCM)
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作者:R M Porter , G Plumton ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.156-170European Cells and Materials (eCM)
摘要:Successful clinical translation of mesenchymal stem cell (MSC)-based therapies for cartilage repair will likely require the implementation of standardised protocols and broadly applicable tools to facilitate the comparisons among cell types and chondroinduction methods. The ...
作者:... E H Frank , A J Grodzinsky , R M Porter
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.34, pp.341-364European Cells and Materials (eCM)
摘要:Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic i...
作者:R M Porter , V Glatt ...
来源:[J].Eur Cell Mater(IF 4.558), 2015, Vol.30, pp.118-131European Cells and Materials (eCM)
摘要:Large segmental defects in bone fail to heal and remain a clinical problem. Muscle is highly osteogenic, and preliminary data suggest that autologous muscle tissue expressing bone morphogenetic protein-2 (BMP-2) efficiently heals critical size defects in rats. Translation into po...
作者:R M Porter , F A Saad ...
来源:[J].Eur Cell Mater(IF 4.558), 2009, Vol.18, pp.96-111European Cells and Materials (eCM)
摘要:We report a novel technology for the rapid healing of large osseous and chondral defects, based upon the genetic modification of autologous skeletal muscle and fat grafts. These tissues were selected because they not only possess mesenchymal progenitor cells and scaffolding prope...

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