Wiley期刊
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作者:Prachi N. Ghule , Jane B. Lian ...
来源:[J].Journal of Cellular Physiology(IF 4.218), 2010, Vol.222 (2), pp.456-464Wiley
摘要:Abstract(#br)Self‐renewal of pluripotent human embryonic stem (hES) cells utilizes an abbreviated cell cycle that bypasses E2F/pRB‐dependent growth control. We investigated whether self‐renewal is alternatively regulated by cyclin/CDK phosphorylation of the p220NPA...
作者:Prachi N. Ghule , Akiko Shimamura ...
来源:[J].Journal of Cellular Physiology(IF 4.218), 2014, Vol.229 (12), pp.1881-1883Wiley
摘要:Abstract(#br)Chromosome segregation and spindle microtubule dynamics are strictly coordinated during cell division in order to preserve genomic integrity. Alterations in the genome that affect microtubule stability and spindle assembly during mitosis may contribute to genomi...
作者:Prachi N. Ghule , Jaclyn A. Therrien ...
来源:[J].Journal of Cellular Physiology(IF 4.218), 2006, Vol.209 (3), pp.883-893Wiley
摘要:Abstract(#br)Competency for self‐renewal of human embryonic stem (ES) cells is linked to pluripotency. However, there is a critical paucity of fundamental parameters of human ES cell division. In this study we show that human ES cells (H1 and H9; NIH‐designated WA01 and WA09...
作者:Prachi N. Ghule , Janet L. Stein
来源:[J].Journal of Cellular Physiology(IF 4.218), 2015, Vol.230 (10), pp.2533-2542Wiley
摘要:The early stages of carcinogenesis are linked to defects in the cell cycle. A series of cell cycle checkpoints are involved in this process. The G1/S checkpoint that serves to integrate the control of cell proliferation and differentiation is linked to carcinogenesis and the...
作者:Prachi N. Ghule , Roxana Rio ...
来源:[J].STEM CELLS(IF 7.701), 2016, Vol.34 (7), pp.1765-1775Wiley
摘要:A bstract(#br)Human embryonic stem cells (hESCs) have an abbreviated G1 phase of the cell cycle that allows rapid proliferation and maintenance of pluripotency. Lengthening of G1 corresponds to loss of pluripotency during differentiation. However, precise mechanisms that lin...
作者:Prachi N. Ghule , Jane B. Lian ...
来源:[J].Journal of Cellular Physiology(IF 4.218), 2017, Vol.232 (6), pp.1254-1257Wiley
摘要:The cell cycle in pluripotent human embryonic stem cells is governed by unique mechanisms that support unrestricted proliferation and competency for endodermal, mesodermal, and ectodermal differentiation. The abbreviated G1 period with retention of uncompromised fidelity for...
作者:Prachi N. Ghule , Jane B. Lian ...
来源:[J].Journal of Cellular Biochemistry(IF 3.062), 2017, Vol.118 (5), pp.953-958Wiley
摘要:ABSTRACT(#br)A novel role for phenotypic transcription factors in very early differentiation was recently observed and merits further study to elucidate what role this precocious expression may have in development. The RUNX1 transcription factor exhibits selective and transi...

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