作者:S. Vimalraj , Nicola C. Partridge , N. Selvamurugan
来源:[J].Journal of Cellular Physiology(IF 4.218), 2014, Vol.229 (9), pp.1236-1244Wiley
摘要:Abstract(#br)Osteoblast differentiation is tightly regulated by several factors including microRNAs (miRNAs). In this paper, we report that pre‐mir‐15b is highly expressed in differentiated osteoblasts. The functional role of miR‐15b in osteoblast differentiation was de...
作者:Nicola C. Partridge , Emi Shimizu ...
来源:[J].Journal of Cellular Physiology(IF 4.218), 2016, Vol.231 (4), pp.798-816Wiley
摘要:Direct application of histone‐deacetylase‐inhibitors (HDACis) to dental pulp cells (DPCs) induces chromatin changes, promoting gene expression and cellular‐reparative events. We have previously demonstrated that HDACis (valproic acid, trichostatin A) increase mineraliza...
来源:[J].Annals of the New York Academy of Sciences(IF 4.375), 2006, Vol.1068 (1), pp.187-193Wiley
摘要:Abstract: In addition to regulating serum calcium and stimulating bone resorption, parathyroid hormone (PTH) is known to stimulate bone formation under certain conditions. The mechanisms behind this counterintuitive anabolic action are largely unknown. We have set out to ide...
作者:... Ling Qin , Nicola C. Partridge , Nagarajan Selvamurugan
来源:[J].Journal of Cellular Biochemistry(IF 3.062), 2005, Vol.95 (5), pp.1002-1011Wiley
摘要:Abstract(#br)Parathyroid hormone (PTH) regulates bone remodeling and calcium homeostasis by acting on osteoblasts. Recently, the gene expression profile changes in the rat PTH (1–34, 10−8M)‐treated rat osteoblastic osteosarcoma cell line, UMR 106‐01, using DN...
作者:... Sharon R. Bloch , Gerald J. Fiacco , Nicola C. Partridge
来源:[J].Journal of Cellular Physiology(IF 4.218), 1999, Vol.181 (3), pp.479-488Wiley
摘要:Abstract(#br)We investigated the regulation of collagenase‐3 expression in normal, differentiating rat osteoblasts. Fetal rat calvarial cell cultures showed an increase in alkaline phosphatase activity reaching maximal levels between 7–14 days postconfluence, then declining ...
作者:... Mariappanadar Vairamani , Nicola C. Partridge , Nagarajan Selvamurugan
来源:[J].Journal of Cellular Physiology(IF 4.218), 2018, Vol.233 (2), pp.1082-1094Wiley
摘要:Transforming growth factor‐beta1 (TGF‐β1), a highly abundant growth factor in skeletal tissues, stimulates matrix metalloproteinase‐13 (MMP‐13) expression in osteoblastic cells. MMP‐13 plays a critical role in bone remodeling. Runx2, a bone transcription factor, is...


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