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作者:Mosnaim Aron D , Hudzik Thomas , Wolf Marion E
来源:[J].American journal of therapeutics, 2015, Vol.22 (6), pp.412-22PubMed
摘要:The effects of the administration [intraperitoneally, 15 and 75 mg/kg, except α-MePEA (amphetamine, AMPH) at 5 and 10 mg/kg] of β-phenylethylamine (PEA), its methylated (o-Me-, p-Me-, α-Me-, β-Me-, N-Me-, p-OMe-, N,N-di-Me-, and 3,4-diOH-N-Me-), para-halogenated (Br-, Cl-, F...
作者:Mosnaim Aron D , Hudzik Thomas , Wolf Marion E
来源:[J].Neurochemical research, 2014, Vol.39 (9), pp.1675-80PubMed
摘要:Administration of β-phenylethylamine (PEA), the simplest endogenous neuroamine, and various methylated PEA derivatives including α-methyl PEA (amphetamine, AMP) elicits analgesia in mice. Five or 20 min after intraperitoneal PEA injection of as little as 6 mg/kg resulted in ...
作者:... Sarda Garima , Casavant Vanessa , Mosnaim Aron D
来源:[J].American journal of therapeutics, 2013, Vol.20 (3), pp.279-91PubMed
摘要:The magnitude of increase in systolic blood pressure in response to the shift from supine to upright posture is considered to reflect the adequacy of orthostatic regulation. Orthostatic integrity is largely maintained by the interaction between the skeletal muscle pump, neurovasc...
作者:Mosnaim Aron D , Chuang FuCheng , Wolf Marion E
来源:[J].American journal of therapeutics, 2011, Vol.18 (1), pp.9-13PubMed
摘要:Changes in the levels or biochemistry of cerebrospinal fluid (CSF) neuropeptides with opioid-like properties have been suggested to reflect alterations in specific biological processes. We have determined various kinetic parameters for methionine-enkephalin (MET) degradation...
作者:Mosnaim Aron D , Maturana Patricio ...
来源:[J].American Journal of Therapeutics, 2012, Vol.19 (3), pp.174-9PubMed
摘要:Results from a longitudinal study (blood drawn at days 29, 64, 89,124, 142, and 182 of the protocol) shows that the concentration of platelet-poor plasma (PPP) methionine(5)-enkephalin (MET) in healthy, drug-free, white male individuals (n = 5) remains within a relatively na...
作者:Mosnaim Aron D , Puente Javier ...
来源:[J].American Journal of Therapeutics(IF 1.29), 2004, Vol.11 (6), pp.459-65PubMed
摘要:We identified a number of clinically used drugs and biologically active endogenous peptides able to significantly decrease the rate of human plasmatic aminopeptidase (AP) leucine-enkephalin (LEU) degradation. Bacitracin, bestatin, fluvoxamine, and each of 4 peptides tested signif...
作者:Mosnaim Aron D , Puente Javier ...
来源:[J].Pharmacology(IF 1.603), 2002, Vol.67 (1), pp.6-13PubMed
摘要:A number of drugs with the phenothiazine molecule in their chemical structure inhibit in a dose-dependent manner human plasmatic aminopeptidase leucine(5)-enkephalin (LEU) metabolism. Half-life peptide degradation was significantly increased by thioridazine > fluphenazine > As-13...
作者:Mosnaim Aron D , Abiola Rasheed ...
来源:[J].American Journal of Therapeutics, 2009, Vol.17 (1), pp.86-91PubMed
摘要:Orthostatic hypotension (OH) is regarded as a decrease primarily in systolic blood pressure on changing position from supine to erect. Based on clinical criteria, it is characterized by a decrease in systolic pressure of 20 mmHg and diastolic pressure of 10 mmHg within 1 to 3 min...
作者:Mosnaim Aron D , Nguyen Tao D ...
来源:[J].American Journal of Therapeutics, 2008, Vol.15 (2), pp.126-30PubMed
摘要:After 10-minute incubation of [3H]-tyrosine methionine-enkephalin (MET) with 100,000 x g supernatant from select brain regions of patients with chronic schizophrenia (n = 3), essentially all of the labeled tyrosine was recovered as the free amino acid. Initial velocity and half-l...

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