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作者:Mosnaim Aron D , Abiola Rasheed ...
来源:[J].American Journal of Therapeutics, 2009, Vol.17 (1), pp.86-91PubMed
摘要:Orthostatic hypotension (OH) is regarded as a decrease primarily in systolic blood pressure on changing position from supine to erect. Based on clinical criteria, it is characterized by a decrease in systolic pressure of 20 mmHg and diastolic pressure of 10 mmHg within 1 to 3 min...
作者:Mosnaim Aron D , Nguyen Tao D ...
来源:[J].American Journal of Therapeutics, 2008, Vol.15 (2), pp.126-30PubMed
摘要:After 10-minute incubation of [3H]-tyrosine methionine-enkephalin (MET) with 100,000 x g supernatant from select brain regions of patients with chronic schizophrenia (n = 3), essentially all of the labeled tyrosine was recovered as the free amino acid. Initial velocity and half-l...
作者:Mosnaim Aron D , Ranade Vasant V ...
来源:[J].American Journal of Therapeutics(IF 1.29), 2006, Vol.13 (3), pp.261-73PubMed
摘要:The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, methylpiperazine, piperazine-ethanol, piperazine-ethyl, or pip...
作者:... Hindes Mariah , Knott Patrick T , Mosnaim Aron D
来源:[J].Clinical Autonomic Research, 2012PubMed
摘要:AIMS: This paper will review literature that examines the psychological and neuropsychological correlates of orthostatic blood pressure regulation. RESULTS: The pattern of change in systolic blood pressure in response to the shift from supine to upright posture reflects the adequ...
作者:Mosnaim Aron D , Maturana Patricio ...
来源:[J].American Journal of Therapeutics, 2012, Vol.19 (3), pp.174-9PubMed
摘要:Results from a longitudinal study (blood drawn at days 29, 64, 89,124, 142, and 182 of the protocol) shows that the concentration of platelet-poor plasma (PPP) methionine(5)-enkephalin (MET) in healthy, drug-free, white male individuals (n = 5) remains within a relatively na...
作者:Mosnaim Aron D , Puente Javier ...
来源:[J].American Journal of Therapeutics(IF 1.29), 2004, Vol.11 (6), pp.459-65PubMed
摘要:We identified a number of clinically used drugs and biologically active endogenous peptides able to significantly decrease the rate of human plasmatic aminopeptidase (AP) leucine-enkephalin (LEU) degradation. Bacitracin, bestatin, fluvoxamine, and each of 4 peptides tested signif...
作者:Mosnaim Aron D , Puente Javier ...
来源:[J].Pharmacology(IF 1.603), 2002, Vol.67 (1), pp.6-13PubMed
摘要:A number of drugs with the phenothiazine molecule in their chemical structure inhibit in a dose-dependent manner human plasmatic aminopeptidase leucine(5)-enkephalin (LEU) metabolism. Half-life peptide degradation was significantly increased by thioridazine > fluphenazine > As-13...
作者:Mosnaim Aron D , Maturana Patricio ...
来源:[J].American Journal of Therapeutics, 2013PubMed
摘要:Eighteen male cluster headache (CH) inpatients within a CH series participated in this research. Blood samples were drawn from patients at least 6-hour pain-free after the last acute CH episode and then shortly prior (SP), during, and soon after (SA) a new acute CH attack. Three ...
作者:Mosnaim Aron D , Callaghan Owen H ...
来源:[J].Neurochemical Research, 2013PubMed
摘要:Phenylethylamine and its monomethylated derivatives p-methylphenylethylamine, α-methylphenylethylamine, phenylethylamine itself, N-methylphenylethylamine, o-methylphenylethylamine, and β-methylphenylethylamine, readily cross the blood-brain barrier showing a brain-uptake ind...

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