PubMed期刊
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作者:Mocchegiani Eugenio , Costarelli Laura ...
来源:[J].Biogerontology(IF 3.19), 2011, Vol.12 (5), pp.455-65PubMed
摘要:Ageing is an inevitable biological process associated with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Nutritional factor, zinc, known to be involved in improving immunity, may remodel some of the age-associated changes,...
作者:Mocchegiani Eugenio , Malavolta Marco ...
来源:[J].Age, 2012PubMed
摘要:Associations between copper to zinc ratio (CZr) and mortality have suggested CZr as a biomarker of aging. Nevertheless, very limited data exist on the association between serum CZr and physical or functional status of very old people. We examined the relationship between serum CZ...
作者:Mocchegiani Eugenio , Basso Andrea ...
来源:[J].Biogerontology(IF 3.19), 2010, Vol.11 (5), pp.589-95PubMed
摘要:The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorph...
作者:Mocchegiani Eugenio , Giacconi Robertina ...
来源:[J].Journal of Clinical Immunology, 2009, Vol.29 (4), pp.416-25PubMed
摘要:INTRODUCTION: During aging, dysregulated immune functions occur contributing to increased susceptibility to morbidity and mortality. However, these dysregulations are normally counterbalanced by continuous adaptation of the body to the deteriorative changes occurring over time. T...
作者:Mocchegiani Eugenio , Giacconi Robertina ...
来源:[J].Experimental Gerontology(IF 3.911), 2008, Vol.43 (5), pp.433-44PubMed
摘要:IL-6 SNP at position -174 is associated with age-related diseases characterized by an impaired Zn status. This polymorphism seems also relevant in regulating the expression of proteins, such as Metallothioneins (MT), involved in the modulation of Zn homeostasis. Since high IL-6 l...
作者:Mocchegiani Eugenio
来源:[J].Rejuvenation Research(IF 2.919), 2008, Vol.11 (2), pp.419-23PubMed
摘要:Aging is characterized by spontaneous biochemical changes that may predispose to increased susceptibility to diseases. Zinc may remodel these changes leading to healthy aging because zinc improves antioxidant defense via CLU protein and genomic stability via PARP-1 nuclear enzyme...
作者:Mocchegiani Eugenio , Giacconi Robertina , Malavolta Marco
来源:[J].Trends in Molecular Medicine(IF 9.571), 2008, Vol.14 (10), pp.419-28PubMed
摘要:A finely tuned subcellular distribution of zinc (Zn), through the coordinated action of Zn transporters (ZnTs) and metallothioneins (MTs), is crucial for optimal cell function. Dysfunctions of these proteins might act as key causative or promoting factors in several chronic patho...
作者:Mocchegiani Eugenio , Malavolta Marco
来源:[J].Genes & Nutrition(IF 3.329), 2008, Vol.3 (2), pp.61-75PubMed
摘要:The pivotal role played by zinc-gene interaction in affecting some relevant cytokines (IL-6 and TNF-alpha) and heat shock proteins (HSP70-2) in ageing, successful ageing (nonagenarians) and the most common age-related diseases, such as atherosclerosis and infections, is now recog...

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