PubMed期刊
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作者:Mocchegiani Eugenio , Malavolta Marco
来源:[J].Journal of Alzheimer's Disease(IF 4.174), 2007, Vol.12 (1), pp.101-9PubMed
摘要:Zinc maintains brain functions because involved in glutaminergic transmission, in antioxidant response and in conferring biological activity to brain enzymes and growth factors. Zinc turnover is mediated by Metallothioneins (MT) which regulate the intracellular free zinc ions [Zn...
作者:Mocchegiani Eugenio
来源:[J].Immunity & Ageing, 2007, Vol.4, pp.5PubMed
摘要:The importance of Zn for optimal functioning of the immune system and antioxidant stress response is well documented. Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, ...
作者:Mocchegiani Eugenio , Giacconi Robertina ...
来源:[J].Immunity & Ageing, 2007, Vol.4, pp.7PubMed
摘要:The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. The...
作者:Mocchegiani Eugenio , Giacconi Robertina ...
来源:[J].New York Academy of Sciences. Annals(IF 4.375), 2007, Vol.1119, pp.129-46PubMed
摘要:Aging is an inevitable biological process that is associated with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Because nutritional factors are involved in improving immune functions, metabolic harmony, and antioxidant def...
作者:Mocchegiani Eugenio , Costarelli Laura ...
来源:[J].MECHANISMS OF AGEING AND DEVELOPMENT(IF 3.264), 2006, Vol.127 (6), pp.517-25PubMed
摘要:In this paper, we reviewed data regarding to the pivotal role played by the zinc-gene interaction in affecting some relevant cytokines (IL-6 and TNF-alpha) and heat shock proteins (Hsp70-2) in ageing, successful ageing (nonagenarians) and in some age-related diseases (atheroscler...
作者:Mocchegiani Eugenio , Costarelli Laura ...
来源:[J].Rejuvenation Research(IF 2.919), 2006, Vol.9 (2), pp.351-4PubMed
摘要:Proteins involved in zinc homeostasis may be altered in aging. This phenomenon may lead to zinc deficiency in the peripheral blood and an accumulation of zinc bound to insoluble aggregates at the extracellular level in the brain. Therefore, it should be more correct to talk about...
作者:Mocchegiani Eugenio , Malavolta Marco ...
来源:[J].Immunity & Ageing, 2006, Vol.3, pp.6PubMed
摘要:The relevance of zinc for proper functioning of the entire immune system is already well documented. However, the identification of individuals who really need zinc supplementation is still debated in view of the fact that excessive zinc may also be toxic. The risk of developing ...
作者:Mocchegiani Eugenio , Santarelli Lory ...
来源:[J].Ageing Research Reviews(IF 5.953), 2006, Vol.5 (3), pp.281-309PubMed
摘要:Thymic re-growth and reactivation of thymic functions may be achieved in old animals by different endocrinological or nutritional manipulations such as, (a) treatment with melatonin, (b) implantation of a growth hormone (GH) secreting tumour cell line (GH3 cells) or treatment wit...
作者:Mocchegiani Eugenio , Costarelli Laura ...
来源:[J].Experimental Gerontology(IF 3.911), 2006, Vol.41 (11), pp.1094-107PubMed
摘要:Zinc is a relevant trace element for the efficiency of the entire immune system. The binding of zinc with some proteins, such as metallothioneins (MT) and alpha-2 macroglobulin (alpha-2M) is crucial for the immune efficiency during ageing and in age-related diseases, because thes...

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