国际光学工程学会
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作者:Krishnan Sathiyamoorthy , Eric M. Strohm , Michael C. Kolios
来源:[J].Journal of Biomedical Optics(IF 2.881), 2017, Vol.22 (4), pp.046001-046001SPIE
摘要:An inexpensive noncontact photoacoustic (PA) imaging system using a low-power continuous wave laser and a kilohertz-range microphone has been developed. The system operates in both optical and PA imaging modes and is designed to be compatible with conventional optical micros...
作者:Michael J. Moore , Joseph A. Sebastian , Michael C. Kolios
来源:[J].Journal of Biomedical Optics(IF 2.881), 2019, Vol.24 (10), pp.106502-106502SPIE
摘要:While the nucleus-to-cytoplasmic (N:C) ratio has traditionally been used for assessing cell malignancy, most N:C measurement techniques are time-consuming and performed on thin histological sections, which prohibit assessment of three-dimensional cell structure. A combined ultrah...
作者:... Christopher B. Riley , Michael C. Kolios , William M. Whelan
来源:[J].Journal of Biomedical Optics(IF 2.881), 2014, Vol.19 (5), pp.056008-056008SPIE
摘要:Optoacoustic (OA) imaging was employed to distinguish normal from neoplastic tissues in a transgenic murine model of prostate cancer. OA images of five tumor-bearing mice and five age-matched controls across a 14 mm × 14 mm region of interest (ROI) on the lower abdomen were ...
作者:... Anoja Giles , Michael C. Kolios , Gregory J. Czarnota
来源:[J].Journal of Biomedical Optics(IF 2.881), 2015, Vol.20 (12), pp.126001-126001SPIE
摘要:Apoptosis is a form of programmed cell death characterized by a series of predictable morphological changes at the subcellular level, which modify the light-scattering properties of cells. We present a spectroscopic optical coherence tomography (OCT) technique to detect changes i...
作者:Krishnan Sathiyamoorthy , Michael C. Kolios
来源:[J].Journal of Biomedical Optics(IF 2.881), 2019, Vol.24 (12), pp.121912-121912SPIE
摘要:We have developed a photoacoustic (PA) sensor using a low-power, continuous- wave laser and a kHz-range microphone. The sensor is simple, flexible, cost-effective, and compatible with commercial optical microscopes. The sensor enables noncontact PA measurements through air, ...
作者:... Steve Miller , Alexander A. Oraevsky , Michael C. Kolios
来源:[J].Journal of Biomedical Optics(IF 2.881), 2019, Vol.24 (12), pp.121915-121915SPIE
摘要:Opto-acoustic imaging involves using light to produce sound waves for visualizing blood in biological tissue. By using multiple optical wavelengths, diagnostic images of blood oxygen saturation and total hemoglobin are generated using endogenous optical contrast, without inj...
作者:Eno Hysi , Ratan K. Saha , Michael C. Kolios
来源:[J].Journal of Biomedical Optics(IF 2.881), 2012, Vol.17 (12), pp.125006-125006SPIE
摘要:Red blood cell (RBC) aggregation and oxygenation are important markers for a variety of blood disorders. No current technique is capable of simultaneously measuring aggregation/oxygenation levels noninvasively. We propose using photoacoustic ultrasound spectroscopy (PAUS) fo...
作者:... Ivan Gorelikov , Naomi Matsuura , Michael C. Kolios
来源:[J].Journal of Biomedical Optics(IF 2.881), 2012, Vol.17 (9), pp.096016-096016SPIE
摘要:Perfluorocarbon droplets containing nanoparticles (NPs) have recently been investigated as theranostic and dual-mode contrast agents. These droplets can be vaporized via laser irradiation or used as photoacoustic contrast agents below the vaporization threshold. This study invest...

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