Springer期刊
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作者:Marcel Verheij , Winald R Gerritsen ...
来源:[J].Radiation Oncology(IF 2.107), 2015, Vol.10 (1)Springer
摘要:Abstract(#br) Background(#br)Radiotherapy is one of the mainstays in the treatment for cancer, but its success can be limited due to inherent or acquired resistance. Mechanisms underlying radioresistance in various cancers are poorly understood and available radiosensitizers have...
作者:... M. Vincent M. Lafleur , Ben J. Slotman , Marcel Verheij
来源:[J].Radiation Oncology(IF 2.107), 2015, Vol.10 (1)Springer
摘要:Abstract(#br) Background(#br)Pro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apoptotic Bcl-2 family members. Increased...
作者:Marcel Verheij , Rogier Boshuizen ...
来源:[J].Journal of Translational Medicine(IF 3.459), 2015, Vol.13 (1)Springer
摘要:Abstract(#br) Background(#br)NHS-IL2 (selectikine, EMD 521873, MSB0010445) consists of human NHS76 (antibody specific for necrotic DNA) fused to genetically modified human interleukin 2 (IL-2) and selectively activates the high-affinity IL-2 receptor. Based on an evolving in...
作者:Marcel Verheij , Matthias Guckenberger ...
来源:[J].Radiation Oncology(IF 2.107), 2016, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)The EORTC has launched a phase II trial to assess safety and efficacy of SBRT for centrally located NSCLC: The EORTC 22113-08113—Lungtech trial. Due to neighbouring critical structures, these tumours remain challenging to treat. To guarantee acco...
作者:... Cornelis JH van de Velde , Marcel Verheij , Annemieke Cats
来源:[J].BMC Cancer(IF 3.333), 2011, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)Radical surgery is the cornerstone in the treatment of resectable gastric cancer. The Intergroup 0116 and MAGIC trials have shown benefit of postoperative chemoradiation and perioperative chemotherapy, respectively. Since these trials cannot be compar...
作者:... Berlinda Jantina de Wit-van der Veen , Marcel Verheij , Marcellus Petrus Maria Stokkel
来源:[J].EJNMMI Research, 2018, Vol.8 (1), pp.1-11Springer
摘要:Abstract(#br) Background(#br)The main challenge for systemic radiation therapy using radiopharmaceuticals (SRT) is to optimise the dose delivered to the tumour, while minimising normal tissue irradiation. Dosimetry could help to increase therapy response and decrease toxicity aft...
作者:Marcel Verheij , Cornelis J. H. Velde
来源:[J].Annals of Surgical Oncology(IF 4.12), 2014, Vol.21 (13), pp.4068-4074Springer
摘要:Abstract(#br) Background(#br)This study was designed to define a statistically sound and clinically meaningful cutoff point for annual hospital volume for esophagectomy. Higher hospital volumes are associated with improved outcomes after esophagectomy. However, reported opti...
作者:... Patrycja L. Gradowska , Marcel Verheij , Johanna W. Sandick
来源:[J].Annals of Surgical Oncology(IF 4.12), 2015, Vol.22 (2), pp.581-588Springer
摘要:Abstract(#br) Objective(#br)The aim of this study was to investigate the impact of adjuvant chemoradiotherapy (CRT) on survival of non-metastatic gastric cancer patients who had undergone an R1 resection.(#br) Methods(#br)We compared the survival of patients after an R1 gast...
作者:... Alexander M. M. Eggermont , Marcel Verheij , Gerben A. Koning
来源:[J].Pharmaceutical Research(IF 4.742), 2015, Vol.32 (4), pp.1354-1367Springer
摘要:Abstract(#br) Purpose(#br)To improve therapeutic activity of mitoxantrone (MTO)-based chemotherapy by reducing toxicity through encapsulation in nanoliposomes and enhancing intracellular drug delivery using short-chain sphingolipid (SCS) mediated tumor cell membrane permeabilizat...

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