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作者:Marcel Henrique Marcondes Sari , Luana Mota Ferreira ...
来源:[J].Colloids and Surfaces B: Biointerfaces(IF 3.554), 2017, Vol.157, pp.464-472Elsevier
摘要:Abstract(#br)The p,p'-methoxyl-diphenyl diselenide [(OMePhSe)2] is an, organoselenium compound that elicits antinociceptive action in different, animal models of pain. However, the compound has physicochemical, Limitations that delay its clinical studies. Herein, (OMePhSe)2, nano...
作者:Marcel Henrique Marcondes Sari , Luana Mota Ferreira ...
来源:[J].European Journal of Pharmaceutics and Biopharmaceutics(IF 3.826), 2017, Vol.117, pp.39-48Elsevier
摘要:Abstract(#br)Organoselenium compounds have been targeted to new therapeutic tools development due to their pharmacological actions. However, some toxicity issues and physicochemical limitations delay the clinical application of these compounds. The incorporation of organosel...
作者:Marcel Henrique Marcondes Sari , Vanessa Angonesi Zborowski ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2018, Vol.111, pp.38-45Elsevier
摘要:Abstract(#br)The current study investigated the effect of organoselenium compound p , p ′-methoxyl-diphenyl diselenide [(OMePhSe) 2 ], free or incorporated into nanocapsules, on behavioral, biochemical and molecular alterations in an inflammatory pain model induced by comple...
作者:Marcel Henrique Marcondes Sari , Vanessa Angonesi Zborowski ...
来源:[J].Journal of Trace Elements in Medicine and Biology(IF 1.959), 2018, Vol.46, pp.17-25Elsevier
摘要:Abstract(#br)Neuropathic pain is a public health problem and its treatment is a global challenge. The organoselenium compound p,p’ -methoxyl-diphenyl diselenide [(OMePhSe) 2 ] has a potential antinociceptive action and its incorporation into nanocapsules improves this action...
作者:Marcel Henrique Marcondes Sari , Elita Ferreira da Silveira ...
来源:[J].Materials Science & Engineering C(IF 2.404), 2017, Vol.74, pp.279-286Elsevier
摘要:Abstract(#br)This study aimed to develop poly(ε-caprolactone) nanocapsules loaded with indole-3-cabinol (I3C) using rose hip oil (RHO) or medium chain triglycerides (MCT) as oil core. In vitro radical scavenging activity (DPPH method), hemolysis, and antitumor effects on bre...
作者:Marcel Henrique Marcondes Sari , Ana Paula Pesarico ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2018, Vol.819, pp.129-135Elsevier
摘要:Abstract(#br)Parkinson's disease (PD) is a dopaminergic neurodegenerative disorder, which presents motor and non-motor symptoms. 7-Fluoro-1,3-diphenylisoquinoline (FDPI) is an isoquinoline compound with antioxidant and antidepressant properties. This study investigated whether FD...
作者:Marcel Henrique Marcondes Sari , Luana Mota Ferreira ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2018, Vol.111, pp.133-141Elsevier
摘要:Abstract(#br)This study aimed the development of nanocapsules (NCs) for oral indole-3-carbinol (I3C) administration and evaluation of antinociceptive potential of this compound in its two forms, free and nanoencapsulated, using acute pain models. NCs showed adequate physicochemic...
作者:Marcel Henrique Marcondes Sari , Ana Cristina Guerra Souza ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2016, Vol.781, pp.25-35Elsevier
摘要:Abstract(#br)This study investigated the potential p -chloro-selenosteroid (PCS) anti-inflammatory effect in different animal models of acute inflammation. In order to determine a time- and a dose-curve response of action, female adult Swiss mice (25–35 g) were divided in di...
作者:Marcel Henrique Marcondes Sari , Ana Cristina Guerra Souza ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2014, Vol.725, pp.79-86Elsevier
摘要:Abstract(#br)This study investigated the antinociceptive action of p -chloro-selenosteroid (PCS), administered by intragastric route (i.g.) to mice against acute models. The contribution of adenosinergic, dopaminergic, serotonergic, nitric oxide and opioid systems was investigate...

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