国际光学工程学会
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作者:Manmohan Singh , Zhaolong Han ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2017, Vol.22 (2), pp.020502-020502SPIE
摘要:Current clinical tools provide critical information about ocular health such as intraocular pressure (IOP). However, they lack the ability to quantify tissue material properties, which are potent markers for ocular tissue health and integrity. We describe a single instrument to m...
作者:Manmohan Singh , Jiasong Li ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2016, Vol.21 (4), pp.046002-046002SPIE
摘要:Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currentl...
作者:Manmohan Singh , Mary E. Dickinson
来源:[J].Journal of Biomedical Optics(IF 2.881), 2016, Vol.21 (5), pp.050902-050902SPIE
摘要:Embryogenesis is a highly complex and dynamic process, and its visualization is crucial for understanding basic physiological processes during development and for identifying and assessing possible defects, malformations, and diseases. While traditional imaging modalities, such a...
作者:Manmohan Singh , Michael D. Twa
来源:[J].Journal of Biomedical Optics(IF 2.881), 2014, Vol.19 (11), pp.110502-110502SPIE
摘要:Structurally degenerative diseases, such as keratoconus, can significantly alter the stiffness of the cornea, directly affecting the quality of vision. Ultraviolet-induced collagen cross-linking (CXL) effectively increases corneal stiffness and is applied clinically to treat kera...
作者:Manmohan Singh , Salavat R. Aglyamov ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2016, Vol.21 (9), pp.090504-090504SPIE
摘要:This study demonstrates the feasibility of using the Rayleigh wave model (RWM) in combination with optical coherence elastography (OCE) technique to assess the viscoelasticity of soft tissues. Dispersion curves calculated from the spectral decomposition of OCE-measured air-p...
作者:Manmohan Singh , Irina V. Larina ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2016, Vol.21 (2), pp.026002-026002SPIE
摘要:Optical coherence tomography (OCT) has been widely used to study mammalian embryonic development with the advantages of high spatial and temporal resolutions and without the need for any contrast enhancement probes. However, the limited imaging depth of traditional OCT might proh...
作者:Manmohan Singh , Shang Wang ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2015, Vol.20 (2), pp.020501-020501SPIE
摘要:We demonstrate the use of a modified Rayleigh–Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis ...
作者:Manmohan Singh , Zhaolong Han ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2016, Vol.21 (9), pp.090502-090502SPIE
摘要:Quantifying tissue biomechanical properties can assist in detection of abnormalities and monitoring disease progression and/or response to a therapy. Optical coherence elastography (OCE) has emerged as a promising technique for noninvasively characterizing tissue biomechanic...
作者:Manmohan Singh , Floredes M. Menodiado ...
来源:[J].Journal of Biomedical Optics(IF 2.881), 2013, Vol.18 (12), pp.121503-121503SPIE
摘要:We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in v...

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