Ivyspring期刊
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作者:Manfred Wiessler , Ute Hennrich ...
来源:[J].Theranostics, 2011, Vol.1, pp.381-394Ivyspring
摘要:Innovative and personalized therapeutic approaches result from the identification and control of individual aberrantly expressed genes at the transcriptional and post-transcriptional level. Therefore, it is of high interest to establish diagnostic, therapeutic and theranosti...
作者:Manfred Wiessler , Waldemar Waldeck ...
来源:[J].International Journal of Medical Sciences, 2010, Vol.7 (4), pp.213-223Ivyspring
摘要:Progress in genome research led to new perspectives in diagnostic applications and to new promising therapies. On account of their specificity and sensitivity, nucleic acids (DNA/RNA) increasingly are in the focus of the scientific interest. While nucleic acids were a target...
作者:Manfred Wiessler , Rüdiger Pipkorn ...
来源:[J].International Journal of Medical Sciences, 2010, Vol.7 (6), pp.326-339Ivyspring
摘要:Clinical experiences often document, that a successful tumor control requires high doses of drug applications. It is widely believed that unavoidable adverse reactions could be minimized by using gene-therapeutic strategies protecting the tumor-surrounding healthy tissue as ...
作者:... Shangfeng Yang , Waldemar Waldeck , Manfred Wiessler
来源:[J].International Journal of Medical Sciences, 2010, Vol.7 (3), pp.136-146Ivyspring
摘要:Among the applications of fullerene technology in health sciences the expanding field of magnetic resonance imaging (MRI) of molecular processes is most challenging. Here we present the synthesis and application of a GdxSc3-xN@C80-BioShuttle-conju...
作者:Manfred Wiessler , Waldemar Waldeck ...
来源:[J].International Journal of Medical Sciences, 2011, Vol.8 (5), pp.387-396Ivyspring
摘要:In the near future personalized medicine with nucleic acids will play a key role in molecular diagnostics and therapy, which require new properties of the nucleic acids, like stability against enzymatic degradation. Here we demonstrate that the replacement of nucleobases wit...
作者:Manfred Wiessler , Katalin Tóth
来源:[J].International Journal of Medical Sciences, 2011, Vol.8 (2), pp.97-105Ivyspring
摘要:Fluorescent proteins (FPs) are established tools for new applications, not-restricted to the cell biological research. They could also be ideal in surgery enhancing the precision to differentiate between the target tissue and the surrounding healthy tissue. FPs like the KillerRed...
作者:Manfred Wiessler , Waldemar Waldeck ...
来源:[J].International Journal of Medical Sciences, 2009, Vol.7 (1), pp.19-28Ivyspring
摘要:The ligation of active pharmaceutical ingredients (API) for working with image processing systems in diagnostics (MRT) attracts increasing notice and scientific interest. The Diels-Alder ligation Reaction with inverse electron demand (DARinv) turns out to be an appropr...
作者:Manfred Wiessler , Ruediger Pipkorn ...
来源:[J].International Journal of Medical Sciences, 2009, Vol.6 (6), pp.338-347Ivyspring
摘要:If metastatic prostate cancer gets resistant to antiandrogen therapy, there are few treatment options, because prostate cancer is not very sensitive to cytostatic agents. Temozolomide (TMZ) as an orally applicable chemotherapeutic substance has been proven to be effective and wel...
作者:Manfred Wiessler , Bernd Didinger
来源:[J].International Journal of Medical Sciences, 2008, Vol.6 (1), pp.18-27Ivyspring
摘要:Progresses in biology and pharmacology led to highly specific bioactive substances, but their poor bioavailability at the site of action is a result of their physico-chemical properties. Various design approaches for transport carrier molecules facilitating the cellular entry of ...
作者:Manfred Wiessler , Volker Ehemann ...
来源:[J].International Journal of Medical Sciences, 2008, Vol.5 (5), pp.273-284Ivyspring
摘要:There is a large number of effective cytotoxic drugs whose side effect profile, efficacy, and long-term use in man are well understood and documented over decades of use in clinical routine e.g. in the treatment of recurrent glioblastoma multiforme (GBM) and the hormone-refractor...

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