PubMed期刊
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作者:Malavolta Marco , Costarelli Laura ...
来源:[J].Cytometry. Part A(IF 3.711), 2006, Vol.69 (10), pp.1043-53PubMed
摘要:: The amount of available intracellular zinc is pivotal to regulate many cellular processes, including oxidative stress response and apoptotic mechanisms. Therefore it is not surprising that zinc homeostasis and dyshomeostasis is involved in many physiological and pathological st...
作者:Malavolta Marco , Cipriano Catia ...
来源:[J].Molecular Medicine(IF 4.469), 2007, Vol.13 (7-8), pp.388-95PubMed
摘要:Carotid artery stenosis (CS) is a well-established risk factor for stroke. Increased proinflammatory chemokines, enhanced metallothionein (MT), and altered metal homeostasis may play roles in atherosclerosis progression and plaque destabilization. MT may sequester zinc during chr...
作者:Mocchegiani Eugenio , Malavolta Marco
来源:[J].Journal of Alzheimer's Disease(IF 4.174), 2007, Vol.12 (1), pp.101-9PubMed
摘要:Zinc maintains brain functions because involved in glutaminergic transmission, in antioxidant response and in conferring biological activity to brain enzymes and growth factors. Zinc turnover is mediated by Metallothioneins (MT) which regulate the intracellular free zinc ions [Zn...
作者:... Tesei Silvia , Gasparini Nazzarena , Malavolta Marco
来源:[J].Immunity & Ageing, 2007, Vol.4, pp.7PubMed
摘要:The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. The...
作者:Vasto Sonya , Malavolta Marco , Pawelec Graham
来源:[J].Immunity & Ageing, 2006, Vol.3, pp.2PubMed
摘要:Longitudinal studies are defining progressive alterations to the immune system associated with increased mortality in the very elderly. Many of these changes are exacerbated by or even caused by chronic T cell stimulation by persistent antigen, particularly from Cytomegalovirus. ...
作者:... Muti Elisa , Tesei Silvia , Malavolta Marco
来源:[J].MECHANISMS OF AGEING AND DEVELOPMENT(IF 3.264), 2006, Vol.127 (6), pp.517-25PubMed
摘要:In this paper, we reviewed data regarding to the pivotal role played by the zinc-gene interaction in affecting some relevant cytokines (IL-6 and TNF-alpha) and heat shock proteins (Hsp70-2) in ageing, successful ageing (nonagenarians) and in some age-related diseases (atheroscler...
作者:Malavolta Marco , Casoli Tiziana ...
来源:[J].MECHANISMS OF AGEING AND DEVELOPMENT(IF 3.264), 2006, Vol.127 (6), pp.590-6PubMed
摘要:Brain performances, e.g. learning and memory, decay during aging. Deterioration of synaptic junctions, as structural correlates of these key functions of the central nervous system, may play a central role in this impairment. Current research on the age-related changes of synapse...
作者:... Muti Elisa , Rink Lothar , Malavolta Marco
来源:[J].Rejuvenation Research(IF 2.919), 2006, Vol.9 (2), pp.351-4PubMed
摘要:Proteins involved in zinc homeostasis may be altered in aging. This phenomenon may lead to zinc deficiency in the peripheral blood and an accumulation of zinc bound to insoluble aggregates at the extracellular level in the brain. Therefore, it should be more correct to talk about...
作者:... Papa Roberta , Malavolta Marco , Mocchegiani Eugenio
来源:[J].Rejuvenation Research(IF 2.919), 2006, Vol.9 (2), pp.333-7PubMed
摘要:It is very interesting and innovative to study the interrelationships between biological characteristics, particularly zinc status, and psychosocial conditions in old age, because there are few and fragmentary data in the literature. The aim of this study was to examine the inter...
作者:Malavolta Marco , Marcellini Fiorella
来源:[J].Immunity & Ageing, 2006, Vol.3, pp.6PubMed
摘要:The relevance of zinc for proper functioning of the entire immune system is already well documented. However, the identification of individuals who really need zinc supplementation is still debated in view of the fact that excessive zinc may also be toxic. The risk of developing ...

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