PubMed期刊
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作者:Macaulay Richard , Franzese Ornella
来源:[J].Immunology, 2012, Vol.135 (4), pp.355-63PubMed
摘要:Highly differentiated CD8(+) CD28(-) CD27(-) T cells have short telomeres, defective telomerase activity and reduced capacity for proliferation. In addition, these cells express increased levels of inhibitory receptors and display defective Akt(ser(473)) phosphorylation following...
作者:Macaulay Richard , Kipling David ...
来源:[J].Journal of Immunology, 2011, Vol.187 (5), pp.2093-100PubMed
摘要:Persistent viral infections and inflammatory syndromes induce the accumulation of T cells with characteristics of terminal differentiation or senescence. However, the mechanism that regulates the end-stage differentiation of these cells is unclear. Human CD4(+) effector memo...
作者:Macaulay Richard , Bemelman Frederike J ...
来源:[J].Journal of Immunology, 2010, Vol.184 (7), pp.3417-23PubMed
摘要:Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as atherosclerosis, but the exact mechanisms generating variations in telomere length are unknown. We hypothesized that induction of differentiated T cells during chronic CMV infection woul...
作者:Macaulay Richard , Libri Valentina ...
来源:[J].Blood, 2009, Vol.113 (26), pp.6619-28PubMed
摘要:Highly differentiated CD8+CD28-CD27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferation, indicating that they are close to replicative senescence. In addition, these cells express increased levels of the senescence-associated inhib...
作者:Macaulay Richard , Akbar Arne N , Henson Sian M
来源:[J].Age, 2013PubMed
摘要:Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic inflammatory state termed inflammaging. The significance of these phenomena is highlighted by their being predictors of earlier mortality. We have recently published that the proinflammat...
作者:Macaulay Richard , Riddell Natalie E ...
来源:[J].Human Immunology, 2012PubMed
摘要:The dysregulated immune response to CMV constitutes a major force driving T cell immunosenescence and growing evidence suggests that it is not a benign virus in old age. We show here that the PD-1/L pathway defines a reversible defect in CMV specific CD8(+) T cell proliferat...

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