PubMed期刊
期刊
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作者:Macaulay Richard , Siddiqui Mohammad Kashif , Stoddart Samuel
来源:[J].Value in health regional issues, 2015, Vol.6, pp.143-149PubMed
摘要:Oncology drugs lacking supportive phase III trial data have achieved Food and Drug Administration (FDA) and European Medicines Agency (EMA) regulatory approval and even European reimbursement approval where no therapeutic alternative exists and early-stage data indicate dramatic ...
作者:Macaulay Richard , Vadlamudi Nirma K ...
来源:[J].Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2017, Vol.20 (10), pp.1245-1251PubMed
摘要:Many health technology assessment (HTA) agencies express a preference for randomized controlled trial evidence when appraising health technologies; nevertheless, it is not always feasible or ethical to conduct such comparative trials.;;To assess the role of noncomparative ev...
作者:Macaulay Richard , Akbar Arne N , Henson Sian M
来源:[J].Age, 2013PubMed
摘要:Ageing is accompanied by alterations to T-cell immunity and also by a low-grade chronic inflammatory state termed inflammaging. The significance of these phenomena is highlighted by their being predictors of earlier mortality. We have recently published that the proinflammat...
作者:Macaulay Richard , Riddell Natalie E ...
来源:[J].Human Immunology, 2012PubMed
摘要:The dysregulated immune response to CMV constitutes a major force driving T cell immunosenescence and growing evidence suggests that it is not a benign virus in old age. We show here that the PD-1/L pathway defines a reversible defect in CMV specific CD8(+) T cell proliferat...
作者:Macaulay Richard , Franzese Ornella
来源:[J].Immunology, 2012, Vol.135 (4), pp.355-63PubMed
摘要:Highly differentiated CD8(+) CD28(-) CD27(-) T cells have short telomeres, defective telomerase activity and reduced capacity for proliferation. In addition, these cells express increased levels of inhibitory receptors and display defective Akt(ser(473)) phosphorylation following...
作者:Macaulay Richard , Kipling David ...
来源:[J].Journal of Immunology, 2011, Vol.187 (5), pp.2093-100PubMed
摘要:Persistent viral infections and inflammatory syndromes induce the accumulation of T cells with characteristics of terminal differentiation or senescence. However, the mechanism that regulates the end-stage differentiation of these cells is unclear. Human CD4(+) effector memo...
作者:Macaulay Richard , Bemelman Frederike J ...
来源:[J].Journal of Immunology, 2010, Vol.184 (7), pp.3417-23PubMed
摘要:Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as atherosclerosis, but the exact mechanisms generating variations in telomere length are unknown. We hypothesized that induction of differentiated T cells during chronic CMV infection woul...
作者:Macaulay Richard , Libri Valentina ...
来源:[J].Blood, 2009, Vol.113 (26), pp.6619-28PubMed
摘要:Highly differentiated CD8+CD28-CD27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferation, indicating that they are close to replicative senescence. In addition, these cells express increased levels of the senescence-associated inhib...

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