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作者:Lian Li , Zhigang Luo ...
来源:[J].Transplant Immunology(IF 1.52), 2017Elsevier
摘要:Abstract(#br)Objective(#br)The immunosuppressive mechanism of sinomenine in organ allotransplantation was investigated, especially its effect of blocking dendritic cell (DC) maturation, which might influence the frequency of regulatory T cells (Tregs).(#br)Methods(#br)Bone marrow...
作者:Lian Li , Qingqing Yang ...
来源:[J].Biomaterials(IF 7.604), 2014, Vol.35 (19), pp.5171-5187Elsevier
摘要:Abstract(#br)Although folate exhibits many advantages over other targeting ligands, it has one major defect: poor water solubility. Once it was conjugated to hydrophilic drug carrier such as N -(2-hydroxypropyl) methacrylamide (HPMA) copolymer, the hydrophobic folate may be burie...
作者:Lian Li , Xi Zhu ...
来源:[J].Biomaterials(IF 7.604), 2015, Vol.65, pp.43-55Elsevier
摘要:Abstract(#br)Tumor cell nucleus-targeted delivery of antitumor agents is of great interest in cancer therapy, since the nucleus is one of the most frequent targets of drug action. Here we report a smart polymeric conjugate platform, which utilizes stimulus-responsive strateg...
作者:Lian Li , Yang Yang ...
来源:[J].Biomaterials(IF 7.604), 2014, Vol.35 (24), pp.6622-6635Elsevier
摘要:Abstract(#br)Increasing the molecular weight of N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers by using micellar structures could result in more pronounced enhanced permeability and retention effect, thus increase the tumor accumulation of drug. However, most micellar ...
作者:Lian Li , Miaoquan Li
来源:[J].Materials Science & Engineering A(IF 2.108), 2017, Vol.698, pp.302-312Elsevier
摘要:Abstract(#br)The kinetic and flow stability analysis of TC17 alloy with a transformed microstructure in the hot deformation of α + β region were carried out. The flow behavior in the hot deformation of TC17 alloy was sensitive to the strain, strain rate and deformation tempe...
作者:Lian Li , Michael Chopp ...
来源:[J].Brain Research(IF 2.879), 2017, Vol.1675, pp.61-70Elsevier
摘要:Abstract(#br)Vascular permeability and hemodynamic alteration in response to the transplantation of human bone marrow stromal cells (hMSCs) after traumatic brain injury (TBI) were longitudinally investigated in non directly injured and normal-appearing cerebral tissue using ...
作者:Lian Li , Minglu Zhou , Yuan Huang
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2018, Vol.536 (1), pp.450-458Elsevier
摘要:Abstract(#br)N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymer has been extensively studied as drug carrier for tumor therapy. Due to the Enhanced Permeability and Retention (EPR) effect, HPMA copolymer drug conjugates are able to be passively accumulated in the tumor site...
作者:Weidong Zheng , Shiwei Yuan , Lian Li
来源:[J].AJIC: American Journal of Infection Control(IF 2.731), 2013, Vol.41 (8), pp.e73-e76Elsevier
摘要:The current study investigated Acinetobacter baumannii isolated from sputum specimens. Compared with previous studies, we found that A baumannii was drug resistant to 14 common antibiotics listed in Clinical and Laboratory Standard Institute guidelines (mean drug resistance rate:...
作者:... Lei Nie , Lian Li , Hengchang Zang
来源:[J].Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy(IF 1.977), 2017Elsevier
摘要:Abstract(#br)With the implementation of quality by design (QbD), critical attributes of raw material (drug substance and excipients) are of significantly importance in pharmaceutical manufacturing process. It is desirable for the quality control of critical material attribut...
作者:... Guilin Chen , Lian Li , Gil Alterovitz
来源:[J].Computers in Biology and Medicine(IF 1.162), 2017, Vol.81, pp.11-23Elsevier
摘要:Abstract(#br)Gene selection seeks to find a small subset of discriminant genes from the gene expression profiles. Current gene selection methods such as wrapper-based models mainly address the issue of obtaining high-quality gene subsets. However, they are considerably time consu...

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