PubMed期刊
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作者:Le Couteur David G , Cogger Victoria C ...
来源:[J].Cardiovascular Pathology, 2010, Vol.20 (3), pp.191-3; author reply 193-4PubMed
作者:Le Couteur David G , Benson Vicky L ...
来源:[J].Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 2010, Vol.66 (1), pp.3-8PubMed
摘要:Circulating factors that have an effect on SIRT1 expression are influenced by caloric restriction. To determine the association between frailty and such circulating factors, we measured serum-induced SIRT1 expression from a nested cohort of frail (n = 77) and robust (n = 82)...
作者:Le Couteur David G , Simpson Stephen J
来源:[J].Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 2010, Vol.66 (2), pp.179-82PubMed
摘要:In the past, it has been assumed that all the biological and medical changes that occur in old age are deleterious. It has therefore been concluded that treatment and prevention of such changes in old age should increase healthspan and delay death. However, accruing epidemiologic...
作者:Le Couteur David G , McLachlan Andrew J ...
来源:[J].Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 2011PubMed
摘要:Despite remarkable technological advances in genetics and drug screening, the discovery of new pharmacotherapies has slowed and new approaches to drug development are needed. Research into the biology of aging is generating many novel targets for drug development that may delay a...
作者:Le Couteur David G , Blyth Fiona M ...
来源:[J].Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, 2010, Vol.65 (7), pp.712-7PubMed
摘要:The relationships between blood tests of liver function and injury (alanine transaminase [ALT], gamma-glutamyl transferase, bilirubin, and albumin) with age, frailty, and survival were investigated in 1,673 community-dwelling men aged 70 years or older. ALT was lower in older par...
作者:Le Couteur David G , Warren Alessandra ...
来源:[J].The Anatomical Record, 2008, Vol.291 (6), pp.672-83PubMed
摘要:Morphological changes in the hepatic sinusoid with old age are increasingly recognized. These include thickening and defenestration of the liver sinusoidal endothelial cell, sporadic deposition of collagen and basal lamina in the extracellular space of Disse, and increased number...

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