PubMed期刊
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作者:LE Couteur David G , Cogger Victoria C ...
来源:[J].New York Academy of Sciences. Annals(IF 4.375), 2007, Vol.1114, pp.79-87PubMed
摘要:The liver sinusoidal endothelial cell (LSEC) influences the transfer of substrates between the sinusoidal blood and hepatocytes and has a major role in endocytosis; therefore, changes in the LSEC have significant implications for hepatic function. There are major morphological ch...
作者:Le Couteur David G , Bailey Lauren , Naganathan Vasi
来源:[J].European Heart Journal(IF 14.097), 2006, Vol.27 (7), pp.887-8; author reply 888-9PubMed
作者:Le Couteur David G , Fraser Robin ...
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2005, Vol.44 (2), pp.187-200PubMed
摘要:The fenestrated sinusoidal endothelium ('liver sieve') and space of Disse in the healthy liver do not impede the transfer of most substrates, including drugs and oxygen, from the sinusoidal lumen to the hepatocyte. Plasma components transfer freely in both directions through the ...
作者:... Muller Michael , Cogger Victoria C , Le Couteur David G
来源:[J].Experimental Gerontology(IF 3.911), 2007, Vol.42 (10), pp.1012-9PubMed
摘要:In old age, the liver contains less ATP and hypoxia-responsive genes are upregulated. Age-related changes in hepatic perfusion and the liver sinusoidal endothelial cell (LSEC) could contribute to this altered hepatic oxygen-dependent metabolism by causing intrahepatocytic hypoxia...
作者:Everitt Arthur V , Le Couteur David G
来源:[J].New York Academy of Sciences. Annals(IF 4.375), 2007, Vol.1114, pp.428-33PubMed
摘要:Long-term reduction in energy intake in the diet (calorie restriction [CR]) extends the life of the laboratory rat by about 25%. However, in humans there are no life-long studies of CR, but only short-term trials which indicate that 20% CR acting over periods of 2-6 years is asso...
作者:... Kwun Sun Young , Cogger Victoria C , LE Couteur David G
来源:[J].New York Academy of Sciences. Annals(IF 4.375), 2007, Vol.1114, pp.88-92PubMed
摘要:Hepatic phase I drug metabolism is diminished in old age. It has been suggested that hepatocyte hypoxia and impaired bioenergetics in old age may contribute to this aging change. Therefore, we sought to determine whether old age was associated with in vivo hypoxia in the aged rat...
作者:Hilmer Sarah N , Cogger Victoria C , Le Couteur David G
来源:[J].Journals of Gerontology. Series A: Biological Sciences & Medical Sciences(IF 4.314), 2007, Vol.62 (9), pp.973-8PubMed
摘要:Age-related changes in Kupffer cell numbers and function may have important implications for systemic immune responses and hepatic function. We compared numbers of Kupffer cells in the hepatic sinusoids and phagocytic function of Kupffer cells in isolated perfused livers of young...
作者:... Muller Michael , Fraser Robin , Le Couteur David G
来源:[J].Atherosclerosis(IF 3.706), 2006, Vol.189 (2), pp.273-81PubMed
摘要:Poloxamer 407 is a ubiquitous synthetic surfactant that causes massive hyperlipidemia and atherosclerosis in the rodent. The initial step in hepatic metabolism of lipoproteins is their transfer through 100-200 nm pores (fenestrations) in the liver sinusoidal endothelial cell, pri...
作者:Le Couteur David G , Fraser Robin ...
来源:[J].Hepatology(IF 12.003), 2006, Vol.44 (5), pp.1182-90PubMed
摘要:The liver has an established ability to induce tolerance. Recent evidence indicates that this unique property might be related to its distinctive architecture allowing T cells to be activated in situ independently of lymphoid tissues. Unlike lymph node-activated T cells, liv...

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