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作者:Laurent Godinas , Laurent Savale ...
来源:[J].European Respiratory Journal(IF 6.355), 2017, Vol.50 (3)
摘要:Pulmonary hypertension (PH) is defined by resting mean pulmonary arterial pressure (mPAP) ≥25 mmHg [1]. Patients with pulmonary vascular disease (PVD) or left heart disease (LHD) may demonstrate abnormal haemodynamic responses to exercise even when resting mPAP is normal [2]...
作者:Laurent Godinas , Edmund M. Lau ...
来源:[J].European Respiratory Journal(IF 6.355), 2016, Vol.48 (1), pp.254-257
摘要:Pulmonary hypertension is defined by a resting mean pulmonary artery pressure (mPAP) ≥25 mmHg [1]. Despite a better understanding of the biology of pulmonary hypertension and new therapeutic advances, pulmonary hypertension remains diagnosed late in its natural history and i...
作者:Laurent Godinas , Edmund M. Lau ...
来源:[J].European Respiratory Journal(IF 6.355), 2016, Vol.47 (2), pp.541-552
摘要:Genetic causes of pulmonary arterial hypertension (PAH) and pulmonary veno-occlusive disease (PVOD) have been identified, leading to a growing need for genetic counselling.(#br)Between 2003 and 2014, genetic counselling was offered to 529 PAH and 100 PVOD patients at the French R...
作者:Laurent Godinas , Olivier Sitbon ...
来源:[J].European Respiratory Journal(IF 6.355), 2016, Vol.47 (5), pp.1436-1444
摘要:A resting mean pulmonary artery pressure (mPAP) of 21–24 mmHg is above the upper limit of normal but does not reach criteria for the diagnosis of pulmonary hypertension (PH). We sought to determine whether an mPAP of 21–24 mmHg is associated with an increased risk of develop...
作者:Laurent Godinas , Frederic Lador ...
来源:[J].European Respiratory Journal(IF 6.355), 2015, Vol.46 (3), pp.728-737
摘要:The previous definition of exercise pulmonary hypertension (PH) with a mean pulmonary artery pressure (mPAP) >30 mmHg was abandoned because healthy individuals can exceed this threshold at high cardiac output (CO). We hypothesised that incorporating assessment of the pressur...
作者:Laurent Godinas , Barbara Joureau ...
来源:[J].European Respiratory Journal(IF 6.355), 2015, Vol.45 (5), pp.1495-1498
摘要:Despite a preserved forced expiratory volume in 1 s (FEV1)/vital capacity (VC), patients with idiopathic or heritable pulmonary arterial hypertension (PAH) may dynamically decrease their inspiratory capacity (IC) during cycle exercise ( i.e. dynamic hyperinflation...
作者:Laurent Godinas , Catharina Belge
来源:[J].European Respiratory Review, 2019, Vol.28 (154)
摘要:Pulmonary arterial hypertension is a rare and incurable chronic disease characterised by a progressive increase in pulmonary vascular resistance and right heart failure. Patient registries collecting observational data can be of great value in the understanding of clinical proble...

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