PubMed期刊
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作者:LaFerla Frank M , Nicoletti Ferdinando ...
来源:[J].Neurobiology of Aging, 2011, Vol.33 (6), pp.1121.e1-12PubMed
摘要:Deficits in glutamate neurotransmission and mitochondrial functions were detected in the frontal cortex (FC) and hippopcampus (HIPP) of aged 3×Tg-Alzheimer's disease (AD) mice, compared with their wild type littermates (non-Tg). In particular, basal levels of glutamate and v...
作者:Laferla Frank M , Oddo Salvador S
来源:[J].Age, 2013PubMed
摘要:With aging and Alzheimer's disease (AD), there is an increased sensitivity to stress along with declines in the memory-associated neurotrophin brain-derived neurotrophic factor in AD. We have replicated this aging phenotype in cultured neurons from aged mice despite being gr...
作者:Kitazawa Masashi , Medeiros Rodrigo , Laferla Frank M
来源:[J].Current Pharmaceutical Design, 2012, Vol.18 (8), pp.1131-47PubMed
摘要:Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential the...
作者:LaFerla Frank M , Vieytes Mercedes R ...
来源:[J].American Chemical Society. Journal, 2012, Vol.134 (17), pp.7467-79PubMed
摘要:Gambierol is a potent neurotoxin that belongs to the family of marine polycyclic ether natural products and primarily targets voltage-gated potassium channels (K(v) channels) in excitable membranes. Previous work in the chemistry of marine polycyclic ethers has suggested the...
作者:Laferla Frank M , Shoji Mikio
来源:[J].Life Sciences, 2012PubMed
摘要:AIMS: We investigated the pathological relevance of the "Aβ oligomer (AβO) cascade hypothesis" in 3xTg-AD mice. This study was also designed to elucidate the molecular mechanism underlying the toxic action of AβOs. MAIN METHODS: To target the extracellular AβOs in vivo, a mo...
作者:Medeiros Rodrigo , Chabrier Meredith A , Laferla Frank M
来源:[J].Journal of Alzheimer's Disease, 2012PubMed
摘要:As the number of patients with Alzheimer's disease (AD) continues to rise, the need for efficacious therapeutics is becoming more and more urgent. Understanding the molecular relationship and interactions between Aβ and tau and their contribution to cognitive decline remain ...
作者:... Moeller Achim , Green Kim N , Laferla Frank M
来源:[J].The American Journal of Pathology, 2012PubMed
摘要:Calpains are cysteine proteinases that selectively cleave proteins in response to calcium signals. Exacerbated activation of calpain has been implicated as a major component in the signaling cascade that leads to β-amyloid (Aβ) production and tau hyperphosphorylation in Alzh...
作者:Laferla Frank M , McLaurin Joanne
来源:[J].Journal of Alzheimer's Disease, 2012PubMed
摘要:Accumulation of amyloid-β peptides (Aβ) and cholinergic degeneration are hallmarks of Alzheimer's disease (AD). In a triple transgenic mouse model of AD (3xTg-AD), soluble Aβ42 levels were detected in the septum by 2 months of age, reaching their highest levels at 3-6 months...
作者:LaFerla Frank M , Rohn Troy T
来源:[J].Journal of Clinical Investigation(IF 12.812), 2004, Vol.114 (1), pp.121-30PubMed
摘要:Neurofibrillary tangles (NFTs) are composed of abnormal aggregates of the cytoskeletal protein tau. Together with amyloid beta (Abeta) plaques and neuronal and synaptic loss, NFTs constitute the primary pathological hallmarks of Alzheimer disease (AD). Recent evidence also sugges...
作者:... Kesslak J Patrick , Cribbs David H , LaFerla Frank M
来源:[J].Neuron(IF 15.766), 2004, Vol.43 (3), pp.321-32PubMed
摘要:Amyloid-beta (Abeta) plaques and neurofibrillary tangles are the hallmark neuropathological lesions of Alzheimer's disease (AD). Using a triple transgenic model (3xTg-AD) that develops both lesions in AD-relevant brain regions, we determined the consequence of Abeta clearance on ...

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