作者:LaFerla Frank M
来源:[J].Biochemical Society. Transactions, 2010, Vol.38 (4), pp.993-5PubMed
摘要:Abeta (amyloid beta-peptide) and tau are the main proteins that misfold and accumulate in amyloid plaques and NFTs (neurofibrillary tangles) of Alzheimer's disease and other neurological disorders. Historically, because plaques and NFTs accumulate in diverse cellular compartments...
作者:LaFerla Frank M , Green Kim N , Oddo Salvatore
来源:[J].Nature Reviews. Neuroscience(IF 31.673), 2007, Vol.8 (7), pp.499-509PubMed
摘要:The primal role that the amyloid-beta (Abeta) peptide has in the development of Alzheimer's disease is now almost universally accepted. It is also well recognized that Abeta exists in multiple assembly states, which have different physiological or pathophysiological effects. Alth...
作者:LaFerla Frank M
来源:[J].Neurobiology of Aging, 2005, Vol.27 (8), pp.1078-80PubMed
摘要:Studying altered gene expression patterns in Alzheimer's disease may be helpful for identifying novel therapeutic targets and for elucidating key cellular processes that are involved in the neurodegenerative phenotype. To date, the advances that have emerged from these types of s...
作者:LaFerla Frank M , Oddo Salvatore
来源:[J].Trends in Molecular Medicine(IF 9.571), 2005, Vol.11 (4), pp.170-6PubMed
摘要:Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by two hallmark lesions: extracellular amyloid plaques and neurofibrillary tangles. The role that these lesions have in the pathogenesis of AD has proven difficult to unravel, in part because of...
作者:LaFerla Frank M , Kitazawa Masashi
来源:[J].Neuron(IF 15.766), 2005, Vol.48 (5), pp.711-2PubMed
摘要:Elevated activity of the Cdk5/p25 complex has been implicated in the pathogenesis of Alzheimer's disease. The report by Fischer and colleagues in this issue of Neuron describes a dichotomous role for the activator protein p25 in synaptic plasticity, learning, and memory, whereby ...
作者:Medeiros Rodrigo , Baglietto-Vargas David , LaFerla Frank M
来源:[J].CNS Neuroscience & Therapeutics, 2010, Vol.17 (5), pp.514-24PubMed
摘要:Tau, the microtubule-associated protein, forms insoluble filaments that accumulate as neurofibrillary tangles in Alzheimer's disease (AD) and related tauopathies. Under physiological conditions, tau regulates the assembly and maintenance of the structural stability of microt...
作者:Laferla Frank M , Goodman Steven R
来源:[J].Journal of Proteomics, 2011, Vol.74 (4), pp.466-79PubMed
摘要:Mitochondrial structural and functional alterations appear to play to an important role in the pathogenesis of Alzheimer's disease (AD). In the present study, we used a quantitative comparative proteomic profiling approach to analyze changes in the mitochondrial proteome in AD. A...
作者:Laferla Frank M , Cristòfol Rosa ...
来源:[J].Journal of Alzheimer's Disease, 2011, Vol.24 (3), pp.421-54PubMed
摘要:Physical exercise is considered to exert a positive neurophysiological effect that helps to maintain normal brain activity in the elderly. Expectations that it could help to fight Alzheimer's disease (AD) were recently raised. This study analyzed the effects of different patterns...
作者:... Rice Tyler B , LaFerla Frank M , Tromberg Bruce J
来源:[J].Annals of biomedical engineering, 2011, Vol.39 (4), pp.1349-57PubMed
摘要:Extensive changes in neural tissue structure and function accompanying Alzheimer's disease (AD) suggest that intrinsic signal optical imaging can provide new contrast mechanisms and insight for assessing AD appearance and progression. In this work, we report the development ...
作者:... Tabira Takeshi , LaFerla Frank M , Kira Jun-ichi
来源:[J].Annals of Neurology, 2011, Vol.69 (2), pp.248-56PubMed
摘要:Intracellular amyloid β-protein (Aβ) contributes to neurodegeneration in Alzheimer disease (AD). Apomorphine (APO) is a dopamine receptor agonist for Parkinson disease and also protects against oxidative stress. Efficacy of APO for an AD mouse model and effects of APO on cel...


资源合作, +86-10-82896619   意见反馈