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作者:... Baglietto-Vargas David , LaFerla Frank M , Glabe Charles G
来源:[J].Molecular neurodegeneration(IF 4.007), 2018, Vol.13 (1), pp.11PubMed
摘要:Besides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer's disease (AD). Microglia are believed to be key mediators of neuroi...
作者:Soto-Faguás Carlos M , Ahmed Tariq ...
来源:[J].Scientific reports(IF 2.927), 2018, Vol.8 (1), pp.6431PubMed
摘要:Accumulation of amyloid-β plaques and tau contribute to the pathogenesis of Alzheimer's disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently of amyloid-β causes beneficial effects on memory and neuropsychiatric symptoms. Selenium, an ...
作者:... Castello Nicholas , Baglietto-Vargas David , LaFerla Frank M
来源:[J].PloS one(IF 3.73), 2014, Vol.9 (9), pp.e106009PubMed
摘要:Neuronal loss is a common component of a variety of neurodegenerative disorders (including Alzheimer's, Parkinson's, and Huntington's disease) and brain traumas (stroke, epilepsy, and traumatic brain injury). One brain region that commonly exhibits neuronal loss in several neurod...
作者:... Sakumi Kunihiko , LaFerla Frank M , Nakabeppu Yusaku
来源:[J].Scientific reports(IF 2.927), 2017, Vol.7 (1), pp.17762PubMed
摘要:Alzheimer's disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and inflammation are considered to play an important role in the development and progression of AD. However, the extent...
作者:... Kang Dongchon , LaFerla Frank M , Nakabeppu Yusaku
来源:[J].Scientific reports(IF 2.927), 2016, Vol.6, pp.37889PubMed
摘要:In the mitochondria-mediated vicious cycle of Alzheimer's disease (AD), intracellular amyloid β (Aβ) induces mitochondrial dysfunction and reactive oxygen species, which further accelerate Aβ accumulation. This vicious cycle is thought to play a pivotal role in the developme...
作者:LaFerla Frank M , Giménez-Llort Lydia
来源:[J].Neuroscience, 2016, Vol.329, pp.284-93PubMed
摘要:Neurochemical alterations in Alzheimer's disease (AD) include cholinergic neuronal loss in the nucleus basalis of Meynert (nbM) and a decrease in densities of the M2 muscarinic receptor subtype in areas related to learning and memory. Neuromodulators present in the cholinerg...
作者:... Trujillo-Estrada Laura , Baglietto-Vargas David , LaFerla Frank M
来源:[J].Journal of Alzheimer's disease : JAD, 2018PubMed
摘要:Alzheimer's disease (AD) impairs memory and causes significant cognitive deficits. The disease course is prolonged, with a poor prognosis, and thus exacts an enormous economic and social burden. Over the past two decades, genetically engineered mouse models have proven indispensa...
作者:LaFerla Frank M , Park Jung Han Yoon ...
来源:[J].Molecular nutrition & food research, 2018, pp.e1800240PubMed
摘要:Sulforaphane is an herbal isothiocyanate enriched in cruciferous vegetables. Here, we investigated whether sulforaphane modulates the production of amyloid-β (Aβ) and tau, the two main pathological factors in Alzheimer's disease (AD).;;A triple transgenic mouse model of AD (...
作者:Laferla Frank M , Demeunynck Martine ...
来源:[J].Journal of neurochemistry, 2015, Vol.132 (5), pp.609-18PubMed
摘要:Previous works have shown the interest of naturally fluorescent proflavine derivatives to label Abeta deposits in vitro. This study aimed to further characterize the properties of the proflavine 3-acetylamino-6-[3-(propargylamino)propanoyl]aminoacridine (COB231) derivative a...
作者:... Martinez-Coria Hilda , LaFerla Frank M , Kitazawa Masashi
来源:[J].Journal of Alzheimer's disease : JAD, 2014, Vol.42 (4), pp.1229-38PubMed
摘要:MicroRNAs are a group of small RNAs that regulate diverse cellular processes including neuronal function. Recent studies have shown that dysregulation of specific microRNAs is critically involved in the development of Alzheimer's disease (AD). Most of these reports have focu...

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