PubMed期刊
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作者:Kokki Hannu , Kumpulainen Elina ...
来源:[J].Pediatrics (English Edition), 2007, Vol.120 (4), pp.e1002-8PubMed
摘要:Ibuprofen is the most commonly used nonsteroidal, antipyretic, antiinflammatory analgesic in children. Nonsteroidal, antipyretic, antiinflammatory analgesics act in both the peripheral tissues and the central nervous system. The central nervous system penetration of ibuprofen has...
作者:Kokki Hannu , Rasanen Ilpo ...
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2006, Vol.45 (7), pp.745-54PubMed
摘要:We evaluated and compared the pharmacokinetics of two oral administration routes of oxycodone parenteral liquid (10 mg/mL)--single buccal and sublingual administration--in 30 generally healthy awake children, aged 6-91 months.;;Two groups of children undergoing inpatient surgery ...
作者:Kokki Hannu , Laisalmi Merja , Vanamo Kari
来源:[J].Journal of Opioid Management, 2007, Vol.2 (5), pp.290-4PubMed
摘要:The results of studies exploring the efficacy of interpleural analgesia in children post-thoracotomy have frequently been inconclusive. In this pilot study, we have evaluated the efficacy and safety of interpleural bupivacaine and intravenous (IV) oxycodone in pain treatment afte...
作者:Kokki Hannu , Ylönen Paula ...
来源:[J].Anesthesia and Analgesia(IF 3.3), 2004, Vol.100 (1), pp.66-70PubMed
摘要:In this clinical trial, we evaluated the clinical effects of ropivacaine for spinal anesthesia in children. An open, prospective study was performed on 93 children, aged 1-17 yr, undergoing elective lower abdominal or lower limb surgery. A plain solution of ropivacaine 5 mg/mL at...
作者:Kokki Hannu , Lintula Hannu ...
来源:[J].Archives of Pediatrics & Adolescent Medicine(IF 4.282), 2005, Vol.159 (4), pp.320-5PubMed
摘要:Analgesics for children with acute abdominal pain are often withheld for fear that they might mask physical examination findings and thus might be unsafe. This viewpoint has been challenged recently.;;To evaluate the effects of buccal oxycodone on pain relief, physical examinatio...
作者:Kokki Hannu , Ylönen Paula ...
来源:[J].Anesthesia and Analgesia(IF 3.3), 2003, Vol.98 (1), pp.64-7, table of contentsPubMed
摘要:In this clinical trial we evaluated the clinical effects of levobupivacaine in spinal anesthesia in children. An open, noncomparative study was performed on 40 children, aged 1-14 yr, undergoing elective lower abdominal or lower limb surgery. A plain solution of S(-)-bupivacaine ...
作者:... Abdelaziz Ahmed Ben , Cherif Rafii , Kokki Hannu
来源:[J].Paediatric Anaesthesia(IF 2.436), 2007, Vol.17 (8), pp.734-7PubMed
摘要:Propofol injection pain is a well-known problem in pediatric anesthesia. Premixture of lidocaine with propofol although effective does not abolish injection pain in all children. Promising results have been reported with pretreatment of the vein with ketamine. The purpose of this...
作者:... Abdelaziz Ahmed Ben , Chattaoui Olfa , Kokki Hannu
来源:[J].Anesthesia and Analgesia, 2007, Vol.105 (2), pp.516-9PubMed
摘要:Spinal anesthesia is increasingly used in adolescents. However, the anesthesia provided by bupivacaine alone may be too short for the planned surgery. The addition of clonidine 2 microg/kg to bupivacaine provides a prolonged anesthetic action but may be associated with hypotensio...
作者:El-Tahtawy Ahmed , Kokki Hannu , Reidenberg Bruce E
来源:[J].The Journal of Clinical Pharmacology(IF 2.841), 2006, Vol.46 (4), pp.433-42PubMed
摘要:Young children are often undertreated for pain. One barrier to effective pain treatment is understanding the pharmacokinetic behavior of analgesics in this age group. Oxycodone is a commonly prescribed opioid for severe pain, yet little is known about its pharmacokinetics in youn...
作者:Kokki Hannu , Heikkinen Marja ...
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2006, Vol.45 (7), pp.737-43PubMed
摘要:The purpose of this study was to evaluate the cerebrospinal fluid (CSF) distribution of an NSAID, ketoprofen, in children. Ketoprofen concentrations were determined from the CSF, plasma and protein-free plasma samples.;;Children (n = 21), aged 13-94 months, were given intravenous...

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