PubMed期刊
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作者:... Litmala Outi , Pasanen Markku , Kokki Hannu
来源:[J].Drugs in R&D, 2016, Vol.16 (2), pp.155-63PubMed
摘要:Oxycodone is the mo st commonly used opioid for the treatment of moderate to severe pain. The peak cerebrospinal fluid concentration after epidural oxycodone was reported to be 300-fold greater (0.025 mM) than when administered intravenously after gynecologic surgery. Additionall...
作者:Kokki Hannu , Kokki Merja ...
来源:[J].Dementia and geriatric cognitive disorders extra, 2016, Vol.6 (2), pp.303-12PubMed
摘要:Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive t...
作者:Kokki Hannu , Tavi Pasi ...
来源:[J].Nucleic acids research, 2018, Vol.46 (3), pp.1124-1138PubMed
摘要:Phospholipids, such as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC), are the major components of cell membranes. Their exposure to reactive oxygen species creates oxidized phospholipids, which predispose to the development of chronic inflammatory diseases an...
作者:Kokki Hannu , Maaroos Martin ...
来源:[J].European journal of clinical pharmacology, 2018PubMed
摘要:Cardiac surgery and conventional extracorporeal circulation (CECC) impair the bioavailability of drugs administered by mouth. It is not known whether miniaturized ECC (MECC) or off-pump surgery (OPCAB) affect the bioavailability in similar manner. We evaluated the metoprolol bioa...
作者:Kokki Hannu , Kaarniranta Kai
来源:[J].Acta ophthalmologica, 2016, Vol.94 Suppl 2, pp.1-34PubMed
摘要:Cataract surgery is the most common ophthalmological surgical procedure, and it is predicted that the number of surgeries will increase significantly in the future. However, little is known about the recovery after surgery. The first aim of this study was to evaluate the prevalen...
作者:Kokki Hannu , Komulainen Jorma ...
来源:[J].Duodecim; lääketieteellinen aikakauskirja, 2016, Vol.132 (8), pp.749-50PubMed
摘要:Management of patients suffering from chronic pain is based on long-term therapeutic relationship. The main objectives of the treatment are pain relief, restoration of function and improvement of quality of life. Interventions for treatment and rehabilitation need to be planned i...
作者:... Selander Tuomas , Kokki Hannu , Eskelinen Matti
来源:[J].Anticancer research, 2016, Vol.36 (6), pp.3005-11PubMed
摘要:To evaluate whether the post-surgery placement of the rectus sheath block analgesia (RSB) reduces the inflammatory response following surgery. The main hypothesis of our study was to find any correlation between patients' pain experience, numeric rating scale (NRS) postopera...
作者:... Pulkki Kari , Ranta Veli-Pekka , Kokki Hannu
来源:[J].Clinical drug investigation, 2016, Vol.36 (7), pp.545-55PubMed
摘要:Based on earlier literature, etoricoxib may have a delayed analgesic effect in postoperative setting when analgesic efficacy of nonselective nonsteroidal anti-inflammatory drug dexketoprofen is rapid. This may be caused by slow penetration of etoricoxib into the central nervous s...
作者:Kokki Hannu , Pulkki Kari
来源:[J].Cancer genomics & proteomics, 2016, Vol.13 (3), pp.239-44PubMed
摘要:The aim of the study was to evaluate whether the post-surgery placement of the rectus sheath block (RSB) analgesia could alter the oxidative stress response. The main hypothesis of our study was to find some correlation between patients' pain experience, numeric rating scale (NRS...
作者:... Kumpulainen Elina , Vähäoja Aura , Kokki Hannu
来源:[J].Anesthesiology and pain medicine, 2016, Vol.6 (3), pp.e33815PubMed
摘要:Several factors are thought to affect the spread and duration of spinal anesthesia (SA) in adults. These include the volume of cerebrospinal fluid (CSF) in the lumbar spinal canal, which has a negative correlation with both the spread and duration of the sensory block.;;We evalua...

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