国际晶体学联合会
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作者:Junsoo Kim , Sunghoon Kim ...
来源:[J].Acta Crystallogr D Biol Crystallogr(IF 14.103), 2013, Vol.69 (Pt 10), pp.2136-2145IUCr
摘要:Aminoacyl-tRNA synthetases recognize cognate amino acids and tRNAs from their noncognate counterparts and catalyze the formation of aminoacyl-tRNAs. Halofuginone (HF), a coccidiostat used in veterinary medicine, exerts its effects by acting as a high-affinity inhibitor of the enz...
作者:Junsoo Kim , Haemin Lee ...
来源:[J].IUCrJ, 2020, Vol.7 (Pt 1), pp.90-99IUCr
摘要:MICAL is an oxidoreductase that participates in cytoskeleton reorganization via actin disassembly in the presence of NADPH. Although three MICALs (MICAL1, MICAL2 and MICAL3) have been identified in mammals, only the structure of mouse MICAL1 has been reported. Here, the first cry...
作者:Junsoo Kim , Byung Chul Kim ...
来源:[J].IUCrJ, 2018, Vol.5 (Pt 6), pp.866-879IUCr
摘要:Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that modifies nuclear proteins by poly(ADP-ribosyl)ation, regulates various cellular activities and restricts the lytic replication of oncogenic gammaherpesviruses by inhibiting the function of replication and transcription a...

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