PubMed期刊
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作者:... Frezza Christian , Henson Sian M , Maini Mala K
来源:[J].Cell reports, 2016, Vol.16 (5), pp.1243-52PubMed
摘要:T cells undergo profound metabolic changes to meet the increased energy demands of maintaining an antiviral response. We postulated that differences in metabolic reprogramming would shape the efficacy of CD8 T cells mounted against persistent viral infections. We found that the p...
作者:... Mills Rachel S , Henson Sian M , Akbar Arne N
来源:[J].Journal of immunology (Baltimore, Md. : 1950), 2016, Vol.197 (7), pp.2891-9PubMed
摘要:NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With age, the incidence of infectious diseases and malignancy rises dramatical...
作者:... Nourshargh Sussan , Akbar Arne N , Henson Sian M
来源:[J].Aging cell, 2018, Vol.17 (1)PubMed
摘要:Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising chemokines, cytokines and extracellular matrix remodelling proteases that are unique to ...
作者:Akbar Arne N , Henson Sian M , Lanna Alessio
来源:[J].Trends in immunology, 2016, Vol.37 (12), pp.866-876PubMed
摘要:As humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. It ...
作者:Henson Sian M , Macaulay Richard ...
来源:[J].Immunology, 2012, Vol.135 (4), pp.355-63PubMed
摘要:Highly differentiated CD8(+) CD28(-) CD27(-) T cells have short telomeres, defective telomerase activity and reduced capacity for proliferation. In addition, these cells express increased levels of inhibitory receptors and display defective Akt(ser(473)) phosphorylation following...
作者:Henson Sian M , Riddell Natalie E , Akbar Arne N
来源:[J].Current Opinion in Immunology, 2012PubMed
摘要:Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation of highly differentiated CD45RA re-expressing memory T cells. These cells increase during ageing, especially in individuals who are infected with cytomegalovirus (CMV). These cells have dec...
作者:Henson Sian M , Akbar Arne N
来源:[J].Advances in Experimental Medicine and Biology(IF 1.825), 2010, Vol.684, pp.189-97PubMed
摘要:Evidence is accumulating that old individuals are more susceptible to infection with organisms to which they were previously immune, indicating that there might be a limit to the persistence of immune memory. The prevailing concept is that defects in memory T-cell populations res...
作者:Henson Sian M , Franzese Ornella ...
来源:[J].Blood, 2009, Vol.113 (26), pp.6619-28PubMed
摘要:Highly differentiated CD8+CD28-CD27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferation, indicating that they are close to replicative senescence. In addition, these cells express increased levels of the senescence-associated inhib...
作者:Henson Sian M , Akbar Arne N
来源:[J].Age, 2009, Vol.31 (4), pp.285-91PubMed
摘要:The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging i...
作者:Henson Sian M , Snelgrove Robert ...
来源:[J].Journal of Immunology(IF 5.52), 2005, Vol.175 (6), pp.4112-8PubMed
摘要:The role of IL-7 during thymopoiesis has led to it being the focus of a number of therapeutic interventions. However, its small size and pleiotropic nature present problems for thymus-directed therapies. We have created a fusion molecule between the extracellular N-terminal domai...

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