PubMed期刊
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作者:Henson Sian M , Akbar Arne N
来源:[J].Advances in Experimental Medicine and Biology(IF 1.825), 2010, Vol.684, pp.189-97PubMed
摘要:Evidence is accumulating that old individuals are more susceptible to infection with organisms to which they were previously immune, indicating that there might be a limit to the persistence of immune memory. The prevailing concept is that defects in memory T-cell populations res...
作者:Henson Sian M , Franzese Ornella ...
来源:[J].Blood, 2009, Vol.113 (26), pp.6619-28PubMed
摘要:Highly differentiated CD8+CD28-CD27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferation, indicating that they are close to replicative senescence. In addition, these cells express increased levels of the senescence-associated inhib...
作者:Henson Sian M , Akbar Arne N
来源:[J].Age, 2009, Vol.31 (4), pp.285-91PubMed
摘要:The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging i...
作者:Henson Sian M , Snelgrove Robert ...
来源:[J].Journal of Immunology(IF 5.52), 2005, Vol.175 (6), pp.4112-8PubMed
摘要:The role of IL-7 during thymopoiesis has led to it being the focus of a number of therapeutic interventions. However, its small size and pleiotropic nature present problems for thymus-directed therapies. We have created a fusion molecule between the extracellular N-terminal domai...
作者:Henson Sian M , Worth Andrew ...
来源:[J].Immunology, 2010, Vol.132 (1), pp.27-38PubMed
摘要:The immune response to human cytomegalovirus (HCMV) infection is characterized by the accumulation of HCMV-specific CD8(+) T cells, particularly in the elderly; such expansions may impair immune responses to other pathogens. We investigated mechanisms underlying HCMV-specifi...
作者:Henson Sian M , Libri Valentina ...
来源:[J].Journal of Immunology, 2011, Vol.187 (5), pp.2093-100PubMed
摘要:Persistent viral infections and inflammatory syndromes induce the accumulation of T cells with characteristics of terminal differentiation or senescence. However, the mechanism that regulates the end-stage differentiation of these cells is unclear. Human CD4(+) effector memo...
作者:Henson Sian M , ten Berge Ineke J M ...
来源:[J].Journal of Immunology, 2010, Vol.184 (7), pp.3417-23PubMed
摘要:Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as atherosclerosis, but the exact mechanisms generating variations in telomere length are unknown. We hypothesized that induction of differentiated T cells during chronic CMV infection woul...
作者:Henson Sian M , Akbar Arne N
来源:[J].Human Immunology, 2010, Vol.71 (7), pp.676-81PubMed
摘要:Human natural killer (NK) cells subsets are phenotypically characterized by their lack of CD3 and low/high expression of CD56. This study revealed an age-associated increase in the ratio of CD3(-)CD56(dim) to CD3(-)CD56(bright) NK cells, whereas distinct expression patterns of CD...
作者:Henson Sian M , Zhang Yan ...
来源:[J].The American Journal of Clinical Nutrition(IF 6.504), 2007, Vol.85 (2), pp.480-7PubMed
摘要:Nutritional status is highly dependent on season in countries such as The Gambia. In a rural Gambian setting, individuals born during periods of seasonal nutritional deprivation ("hungry seasons") are susceptible to mortality from infectious diseases in adult life.;;We inves...
作者:Henson Sian M , Ngom Pa Tamba ...
来源:[J].Rejuvenation Research(IF 2.919), 2007, Vol.10 (1), pp.5-17PubMed
摘要:Old age is accompanied by an increased incidence of infection and poorer responses to vaccination. In this proof of principle study, old female rhesus macaques (aged 18.5 to 23.9 years) were treated with recombinant simian interleukin-7 (IL-7) or saline, according to a two-p...

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