PubMed期刊
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作者:Henson Sian M , Snelgrove Robert ...
来源:[J].Journal of Immunology(IF 5.52), 2005, Vol.175 (6), pp.4112-8PubMed
摘要:The role of IL-7 during thymopoiesis has led to it being the focus of a number of therapeutic interventions. However, its small size and pleiotropic nature present problems for thymus-directed therapies. We have created a fusion molecule between the extracellular N-terminal domai...
作者:Henson Sian M , Aspinall Richard ...
来源:[J].Journal of Immunology(IF 5.52), 2005, Vol.175 (3), pp.1566-74PubMed
摘要:We have recently described an IL-2/IL-4-producing CD8+CD25+ non-regulatory memory T cell population that occurs in a subgroup of healthy elderly persons who characteristically still have a good humoral response after vaccination. The present study addresses this specific T cell s...
作者:... Frezza Christian , Henson Sian M , Maini Mala K
来源:[J].Cell reports, 2016, Vol.16 (5), pp.1243-52PubMed
摘要:T cells undergo profound metabolic changes to meet the increased energy demands of maintaining an antiviral response. We postulated that differences in metabolic reprogramming would shape the efficacy of CD8 T cells mounted against persistent viral infections. We found that the p...
作者:... Mills Rachel S , Henson Sian M , Akbar Arne N
来源:[J].Journal of immunology (Baltimore, Md. : 1950), 2016, Vol.197 (7), pp.2891-9PubMed
摘要:NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With age, the incidence of infectious diseases and malignancy rises dramatical...
作者:Henson Sian M , Macaulay Richard ...
来源:[J].Immunology, 2012, Vol.135 (4), pp.355-63PubMed
摘要:Highly differentiated CD8(+) CD28(-) CD27(-) T cells have short telomeres, defective telomerase activity and reduced capacity for proliferation. In addition, these cells express increased levels of inhibitory receptors and display defective Akt(ser(473)) phosphorylation following...
作者:Henson Sian M , Riddell Natalie E , Akbar Arne N
来源:[J].Current Opinion in Immunology, 2012PubMed
摘要:Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation of highly differentiated CD45RA re-expressing memory T cells. These cells increase during ageing, especially in individuals who are infected with cytomegalovirus (CMV). These cells have dec...
作者:Henson Sian M , Akbar Arne N
来源:[J].Advances in Experimental Medicine and Biology(IF 1.825), 2010, Vol.684, pp.189-97PubMed
摘要:Evidence is accumulating that old individuals are more susceptible to infection with organisms to which they were previously immune, indicating that there might be a limit to the persistence of immune memory. The prevailing concept is that defects in memory T-cell populations res...
作者:Henson Sian M , Franzese Ornella ...
来源:[J].Blood, 2009, Vol.113 (26), pp.6619-28PubMed
摘要:Highly differentiated CD8+CD28-CD27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferation, indicating that they are close to replicative senescence. In addition, these cells express increased levels of the senescence-associated inhib...
作者:Henson Sian M , Akbar Arne N
来源:[J].Age, 2009, Vol.31 (4), pp.285-91PubMed
摘要:The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular differentiation, data are emerging i...
作者:Henson Sian M , Pido-Lopez Jeffrey , Aspinall Richard
来源:[J].Experimental Gerontology(IF 3.911), 2004, Vol.39 (4), pp.673-8PubMed
摘要:Age-associated thymic atrophy is a key event preceding the inefficient functioning of the immune system, resulting in a diminished capacity to generate new T-cells. This thymic involution has been proposed to be due to changes in the thymic microenvironment resulting in its failu...

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