Elsevier期刊
期刊
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作者:John M Leavitt , Hal S Alper
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2015, Vol.34, pp.98-104Elsevier
摘要:Gene expression control is critical to increase production of recombinant proteins, fine-tune metabolic pathways and reliably express synthetic pathways. The importance of transcriptional control seems to be most important in eukaryotic systems. In this review, we highlight ...
作者:Lauren T Cordova , Hal S Alper
来源:[J].Current Opinion in Chemical Biology(IF 9.471), 2016, Vol.35, pp.37-42Elsevier
摘要:Central carbon metabolism is conserved among all organisms for cellular function and energy generation. The connectivity of this metabolic map gives rises to key metabolite nodes. Five of these nodes in particular, pyruvate, citric acid, tyrosine and aspartate, acetyl-CoA, serve ...
作者:Joseph K Cheng , Hal S Alper
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2014, Vol.30, pp.87-94Elsevier
摘要:The increase in quality, quantity, and complexity of recombinant products heavily drives the need to predictably engineer model and complex (mammalian) cell systems. However, until recently, limited tools offered the ability to precisely manipulate their genomes, thus impeding th...
作者:Holly Ekas , Matthew Deaner , Hal S Alper
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2019, Vol.57, pp.1-9Elsevier
摘要:Due to unsustainable petroleum supply and poor yields from plant and animal sources, there is an increased effort to engineer microbial hosts for renewable chemical production. When compared to microbes such as Escherichia coli , fungal hosts show advantages due to their natural ...
作者:Amanda M Lanza , Nathan C Crook , Hal S Alper
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2012, Vol.23 (5), pp.712-717Elsevier
摘要:The promises of modern biotechnology hinge upon the hope that we can understand microscopic cellular complexity and in doing so create novel function. In this regard, the fields of systems and synthetic biology are important for accelerating both our understanding of biological s...
作者:Leqian Liu , Heidi Redden , Hal S Alper
来源:[J].Current Opinion in Biotechnology(IF 7.86), 2013, Vol.24 (6), pp.1023-1030Elsevier
摘要:Microbial systems provide an attractive, renewable route to produce desired organic molecules such as fuels and chemicals. While attention within the field of metabolic engineering has mostly focused on Escherichia coli , yeast is a potent host and growing host for industrial pro...
作者:Amanda M Lanza , Joseph K Cheng , Hal S Alper
来源:[J].Current Opinion in Chemical Engineering, 2012, Vol.1 (4), pp.403-410Elsevier
摘要:The increase in quality, quantity, and complexity of recombinant products relies heavily on the ability to engineer mammalian cell systems. However, the complexity of mammalian cells and lack of synthetic tools to manipulate them impede cell line development processes. Furthermor...

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