European Cells and Materials (eCM)
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作者:... E Farrell , S G Kluijtmans , G J van Osch
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.35, pp.242-254European Cells and Materials (eCM)
摘要:The aim of the current study was to reduce the clinically used supra-physiological dose of bone morphogenetic protein-2 (BMP-2) (usually 1.5 mg/mL), which carries the risk of adverse events, by using a more effective release system. A slow release system, based on an injecta...
作者:G J van Osch , N Kops ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.218-230European Cells and Materials (eCM)
摘要:Mesenchymal stem cells (MSCs) represent a promising biological therapeutic option as an osteoarthritis (OA)-modifying treatment. MSCs secrete factors that can counteract inflammatory and catabolic processes and attract endogenous repair cells. The effects of intra-articular ...
作者:... S Clockaerts , Y M Bastiaansen-Jenniskens , G J van Osch
来源:[J].Eur Cell Mater(IF 4.558), 2015, Vol.30, pp.303-314European Cells and Materials (eCM)
摘要:Cartilage repair by bone marrow derived mesenchymal stem cells (MSCs) can be influenced by inflammation in the knee. Next to synovium, the infrapatellar fat pad (IPFP) has been described as a source for inflammatory factors. Here, we investigated whether factors secreted by the I...
作者:... M R Bernsen , G M van Buul , G J van Osch
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.33, pp.43-58European Cells and Materials (eCM)
摘要:Bone marrow derived mesenchymal stem cells (MSCs) have immunomodulatory and trophic capacities. For therapeutic application in local chronic inflammatory diseases, MSCs, preferably of allogeneic origin, have to retain immunomodulatory properties. This might be achieved by encapsu...
作者:... R M Poublon , K S Stok , G J van Osch
来源:[J].Eur Cell Mater(IF 4.558), 2014, Vol.27, pp.264-280European Cells and Materials (eCM)
摘要:Cartilage has limited self-regenerative capacity. Tissue engineering can offer promising solutions for reconstruction of missing or damaged cartilage. A major challenge herein is to define an appropriate cell source that is capable of generating a stable and functional matri...

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