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作者:Dergalev Alexander A , Alexandrov Alexander I ...
来源:[J].International journal of molecular sciences(IF 2.464), 2019, Vol.20 (11)PubMed
摘要:The yeast [ PSI +] prion, formed by the Sup35 (eRF3) protein, has multiple structural variants differing in the strength of nonsense suppressor phenotype. Structure of [ PSI +] and its variation are characterized poorly. Here, we mapped Sup35 amyloid cores of 26 [ PSI +] ex vivo ...
作者:... Mitkevich Olga V , Dergalev Alexander A , Ter-Avanesyan Michael D
来源:[J].International journal of molecular sciences(IF 2.464), 2018, Vol.19 (11)PubMed
摘要:The [ PSI ⁺] nonsense-suppressor determinant of Saccharomyces cerevisiae is based on the formation of heritable amyloids of the Sup35 (eRF3) translation termination factor. [ PSI ⁺] amyloids have variants differing in amyloid structure and in the strength of the suppressor p...
作者:Dergalev Alexander A , Ter-Avanesyan Michael D
来源:[J].PloS one(IF 3.73), 2014, Vol.9 (12), pp.e116003PubMed
摘要:Despite extensive study, progress in elucidation of biological functions of amyloids and their role in pathology is largely restrained due to the lack of universal and reliable biochemical methods for their discovery. All biochemical methods developed so far allowed only identifi...
作者:Kushnirov Vitaly V , Dergalev Alexander A , Alexandrov Alexander I
来源:[J].Prion, 2020, Vol.14 (1), pp.11-19PubMed
摘要:Amyloids and their infectious subset, prions, represent fibrillary aggregates with regular structure. They are formed by proteins that are soluble in their normal state. In amyloid form, all or part of the polypeptide sequence of the protein is resistant to treatment with protein...
作者:Alexandrov Alexander I , Dergalev Alexander A
来源:[J].MethodsX, 2019, Vol.6, pp.329-332PubMed
摘要:Microscopy of multiple samples using slides and coverslips is time consuming and good images are sometimes difficult to obtain due to cell movement. Our method involves manual spotting of multiple cell samples onto solid-medium pads, which creates the following benefits: •Ra...
作者:Dergalev Alexander A , Kushnirov Vitaly V ...
来源:[J].Biology open, 2019, Vol.8 (7)PubMed
摘要:Proteins can aggregate in response to stresses, including hyperosmotic shock. Formation and disassembly of aggregates is a relatively slow process. We describe a novel instant response of the cell to hyperosmosis, during which chaperones and other proteins form numerous foci with...
作者:Dergalev Alexander A , Alexandrov Alexander I ...
来源:[J].International journal of molecular sciences(IF 2.464), 2019, Vol.20 (11)PubMed
摘要:The yeast [ PSI +] prion, formed by the Sup35 (eRF3) protein, has multiple structural variants differing in the strength of nonsense suppressor phenotype. Structure of [ PSI +] and its variation are characterized poorly. Here, we mapped Sup35 amyloid cores of 26 [ PSI +] ex vivo ...

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