Elsevier期刊
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作者:Sankalp Malhotra , Don Hayes , Daniel J. Wozniak
来源:[J].Journal of Cystic Fibrosis(IF 2.873), 2019, Vol.18 (6), pp.796-803Elsevier
摘要:Abstract(#br)Background(#br)Pseudomonas aeruginosa is the prominent bacterial pathogen in the cystic fibrosis (CF) lung and contributes to significant morbidity and mortality. Though P. aeruginosa strains initially colonizing the CF lung have a nonmucoid colony morphology, they o...
作者:... Jack C. Yalowich , Daniel J. Wozniak , Mark J. Mitton-Fry
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2018Elsevier
摘要:Abstract(#br)Novel bacterial type II topoisomerase inhibitors (NBTIs) constitute a promising new class of antibacterial agents. We report a series of NBTIs with potent anti-staphylococcal activity and diminished hERG inhibition. Dioxane-linked compound 9 demonstrated MICs ≤1...
作者:... Sarah Chaney , Daniel J. Wozniak , Larry S. Schlesinger
来源:[J].Tuberculosis(IF 3.033), 2018, Vol.108, pp.201-210Elsevier
摘要:Abstract(#br)Granulomas are the histopathologic hallmark of tuberculosis (TB), both in latency and active disease. Diagnostic and therapeutic strategies that specifically target granulomas have not been developed. Our objective is to develop a probe for imaging relevant immune ce...
作者:Sankalp Malhotra , Don Hayes , Daniel J. Wozniak
来源:[J].Journal of Cystic Fibrosis(IF 2.873), 2019Elsevier
摘要:Abstract(#br)Background(#br)Pseudomonas aeruginosa is the prominent bacterial pathogen in the cystic fibrosis (CF) lung and contributes to significant morbidity and mortality. Though P. aeruginosa strains initially colonizing the CF lung have a nonmucoid colony morphology, they o...
作者:... Sean E. Ervin , Daniel J. Wozniak , Steven B. Mizel
来源:[J].Vaccine(IF 3.492), 2009, Vol.27 (48), pp.6762-6769Elsevier
摘要:Abstract(#br)There is currently no approved vaccine against Pseudomonas aeruginosa , the major cause of morbidity and mortality in cystic fibrosis (CF) patients and a major pathogen in ventilated and burn patients. In a previous study, we demonstrated the immunization of mic...
作者:Daniel J. Wozniak , Sung-Hei Hwang ...
来源:[J].Advanced Drug Delivery Reviews(IF 12.888), 2002, Vol.54 (11), pp.1425-1443Elsevier
摘要:Abstract(#br)Recent evidence indicates that Pseudomonas aeruginosa residing as biofilms in airway mucus of cystic fibrosis (CF) patients is undergoing anaerobic metabolism, a form of growth requiring gene products that are not utilized during aerobic growth. The outer membrane pr...
作者:Timna J.O. Wyckoff , Daniel J. Wozniak
来源:[J].Methods in Enzymology(IF 2.002), 2001, Vol.336, pp.144-151Elsevier
摘要:Publisher Summary(#br)This chapter discusses Pseudomonas aeruginosa , a common gram-negative bacterium found mainly in soil and water that poses minimal threat to healthy individuals, and is the major cause of death in patients suffering from cystic fibrosis (CF). In these patien...
作者:... Stefania Fabbri , Daniel J. Wozniak , Paul Stoodley
来源:[J].Biofilm, 2020, Vol.2Elsevier
摘要:Abstract(#br)It has long been recognized that biofilms are viscoelastic materials, however the importance of this attribute to the survival and persistence of these microbial communities is yet to be fully realized. Here we review work, which focuses on understanding biofilm mech...
作者:Daniel J. Wozniak , David W. McComb
来源:[J].iScience, 2020, Vol.23 (2)Elsevier
摘要:Summary(#br)Pseudomonas aeruginosa biofilms represent a major threat to health care. Rugose small colony variants (RSCV) of P . aeruginosa , isolated from chronic infections, display hyperbiofilm phenotype. RSCV biofilms are highly resistant to antibiotics and host defenses....

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