European Cells and Materials (eCM)
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作者:D H Rosenzweig , R Fairag ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.200-217European Cells and Materials (eCM)
摘要:Numerous studies show promise for cell-based tissue engineering strategies aiming to repair painful intervertebral disc (IVD) degeneration. However, clinical translation to human IVD repair is slow. In the present study, the regenerative potential of an autologous nucleus pu...
作者:D H Rosenzweig , R Gawri ...
来源:[J].Eur Cell Mater(IF 4.558), 2016, Vol.30, pp.26-39European Cells and Materials (eCM)
摘要:Low back pain originating from intervertebral disc (IVD) degeneration affects the quality of life for millions of people, and it is a major contributor to global healthcare costs. Long-term culture of intact IVDs is necessary to develop ex vivo models of human IVD degenerati...
作者:D H Rosenzweig , J Tremblay Gravel ...
来源:[J].Eur Cell Mater(IF 4.558), 2017, Vol.33, pp.240-251European Cells and Materials (eCM)
摘要:Autologous NP cell implantation is a potential therapeutic avenue for intervertebral disc (IVD) degeneration. However, monolayer expansion of cells isolated from surgical samples may negatively impact matrix production by way of dedifferentiation. Previously, we have used a ...
作者:D H Rosenzweig , E Krock ...
来源:[J].Eur Cell Mater(IF 4.558), 2014, Vol.28, pp.98-111European Cells and Materials (eCM)
摘要:Excessive mechanical loading or acute trauma to intervertebral discs (IVDs) is thought to contribute to degeneration and pain. However, the exact mechanisms by which mechanical injury initiates and promotes degeneration remain unclear. This study investigates biochemical cha...

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