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作者:Choi Hyun-Ji , Jang Sungwoong ...
来源:[J].BMC veterinary research(IF 1.861), 2016, Vol.12 (1), pp.164PubMed
摘要:Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits of Polycomb repressive complex 2, a crucial epigenetic regulator. EZH2...
作者:Choi Hyun-Ji , Lee Sora ...
来源:[J].International journal of molecular sciences(IF 2.464), 2018, Vol.19 (10)PubMed
摘要:This study aimed to evaluate the usefulness of four microRNAs (miRNAs) in an acute pancreatic injury dog model. Acute pancreatitis was induced by infusion of cerulein for 2 h (7.5 μg/kg/h). The levels of well-known miRNAs, microRNA-216a (miR-216a) and microRNA-375 (miR-375),...
作者:Choi Hyun-Ji , Lee Han-Byul ...
来源:[J].Comparative medicine(IF 1.12), 2018, Vol.68 (2), pp.148-155PubMed
摘要:Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in v...
作者:Choi Hyun-Ji , Lee Han-Byul ...
来源:[J].Comparative medicine(IF 1.12), 2018, Vol.68 (2), pp.148-155PubMed
摘要:Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in v...
作者:Choi Hyun-Ji , Lee Han-Byul ...
来源:[J].Comparative medicine(IF 1.12), 2019, Vol.68 (2), pp.148-155PubMed
摘要:Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in v...
作者:Choi Hyun-Ji , Jang Sungwoong ...
来源:[J].Comparative medicine(IF 1.12), 2015, Vol.65 (5), pp.409-15PubMed
摘要:Nonalcoholic fatty liver disease (NAFLD) can lead to cirrhosis, hepatocellular carcinoma, and ultimately death. Magnetic resonance techniques are accurate, noninvasive methods for evaluating hepatic steatosis but, in animals, have not been fully validated against histologic findi...
作者:Choi Hyun-Ji , Jang Sungwoong ...
来源:[J].Comparative medicine(IF 1.12), 2015, Vol.65 (5), pp.409-15PubMed
摘要:Nonalcoholic fatty liver disease (NAFLD) can lead to cirrhosis, hepatocellular carcinoma, and ultimately death. Magnetic resonance techniques are accurate, noninvasive methods for evaluating hepatic steatosis but, in animals, have not been fully validated against histologic findi...
作者:Choi Hyun-Ji , Jang Sungwoong ...
来源:[J].Journal of veterinary science, 2016, Vol.17 (1), pp.45-51PubMed
摘要:Drug-induced liver injury (DILI) is a significant threat to patient health and a major concern during drug development. Recently, multiple circulating microRNAs (miRNAs) have been reported to be potential biomarkers for DILI. To adapt and validate miRNAs for clinical use, we inve...
作者:Choi Hyun-Ji , Jo Woori ...
来源:[J].Journal of applied toxicology : JAT, 2013PubMed
摘要:CKD-501 is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist that is effective for the treatment of diabetes. However, its carcinogenic potential remains controversial. The current carcinogenicity study was conducted over a period of 104 weeks in ICR mice. T...

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