PubMed期刊
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作者:Choi Hyun-Ji , Jang Sungwoong ...
来源:[J].BMC veterinary research(IF 1.861), 2016, Vol.12 (1), pp.164PubMed
摘要:Current studies report that aberrations in epigenetic regulators or chromatin modifications are related to tumor development and maintenance. EZH2 (Enhancer of zeste homolog 2) is one of the catalytic subunits of Polycomb repressive complex 2, a crucial epigenetic regulator. EZH2...
作者:Choi Hyun-Ji , Lee Han-Byul ...
来源:[J].Comparative medicine(IF 1.12), 2018, Vol.68 (2), pp.148-155PubMed
摘要:Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in v...
作者:Choi Hyun-Ji , Lee Han-Byul ...
来源:[J].Comparative medicine(IF 1.12), 2019, Vol.68 (2), pp.148-155PubMed
摘要:Enhancer of zeste homolog 2 (EZH2) shows upregulated expression in tumors and is an important driver of tumor development and progression. However, the mechanism underlying the mediation of tumor aggressiveness by EZH2 remains unclear. We here investigated the levels of EZH2 in v...
作者:Choi Hyun-Ji , Jang Sungwoong ...
来源:[J].Comparative medicine(IF 1.12), 2015, Vol.65 (5), pp.409-15PubMed
摘要:Nonalcoholic fatty liver disease (NAFLD) can lead to cirrhosis, hepatocellular carcinoma, and ultimately death. Magnetic resonance techniques are accurate, noninvasive methods for evaluating hepatic steatosis but, in animals, have not been fully validated against histologic findi...
作者:Choi Hyun-Ji , Jang Sungwoong ...
来源:[J].Journal of veterinary science, 2016, Vol.17 (1), pp.45-51PubMed
摘要:Drug-induced liver injury (DILI) is a significant threat to patient health and a major concern during drug development. Recently, multiple circulating microRNAs (miRNAs) have been reported to be potential biomarkers for DILI. To adapt and validate miRNAs for clinical use, we inve...
作者:Choi Hyun-Ji , Jo Woori ...
来源:[J].Journal of applied toxicology : JAT, 2013PubMed
摘要:CKD-501 is a peroxisome proliferator-activated receptor gamma (PPARγ) agonist that is effective for the treatment of diabetes. However, its carcinogenic potential remains controversial. The current carcinogenicity study was conducted over a period of 104 weeks in ICR mice. T...
作者:Choi Hyun-Ji , Cho Sung-Min ...
来源:[J].Current eye research, 2018, pp.1-7PubMed
摘要:To (i) evaluate the efficacy and safety of HL036, a tumor-necrosis factor (TNF)-α-blocking protein, in the treatment of naturally occurring canine keratoconjunctivitis sicca (KCS) and (ii) compare these features with those of 1% cyclosporine A (CsA).;;Dogs (n = 29) diagnosed...
作者:Choi Hyun-Ji , Son Woo-Chan ...
来源:[J].The Journal of nutritional biochemistry, 2016, Vol.27, pp.43-52PubMed
摘要:Complement-C1q/tumor necrosis factor-α related protein 1 (CTRP1) is a 35-kDa glycoprotein that is secreted from various tissues. Although CTRP1 is highly increased in patients with type II diabetes and obesity, the metabolic roles of CTRP1 remain largely unknown. To unveil t...
作者:Choi Hyun-Ji , Ryu Jae-Eun ...
来源:[J].Molecular medicine reports, 2016, Vol.13 (1), pp.146-52PubMed
摘要:Antitumor effects of metformin have recently emerged despite its original use for type II diabetes. In the present study, the effects of metformin on the development and recurrence of hepatocellular carcinoma (HCC) were investigated using the diethylnitrosamine (DEN)‑induced...

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