PubMed期刊
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作者:Childress Paul J , Chakraborty Nabarun ...
来源:[J].Scientific reports(IF 2.927), 2019, Vol.9 (1), pp.11419PubMed
摘要:Spaceflight results in reduced mechanical loading of the skeleton, which leads to dramatic bone loss. Low bone mass is associated with increased fracture risk, and this combination may compromise future, long-term, spaceflight missions. Here, we examined the systemic effects...
作者:Childress Paul J , Scofield David C ...
来源:[J].Comparative medicine(IF 1.12), 2018, Vol.68 (2), pp.131-138PubMed
摘要:Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents). Thus, the unique spaceflight laboratory on the International Space Station presents the oppor...
作者:Childress Paul J , Scofield David C ...
来源:[J].Comparative medicine(IF 1.12), 2019, Vol.68 (2), pp.131-138PubMed
摘要:Spaceflight results in bone loss like that associated with osteoporosis or decreased weight-bearing (for example, high-energy trauma such as explosive injuries and automobile accidents). Thus, the unique spaceflight laboratory on the International Space Station presents the oppor...
作者:Childress Paul J , Adaway Michele ...
来源:[J].American journal of physiology. Endocrinology and metabolism, 2019PubMed
摘要:A goal of osteoporosis therapy is to restore lost bone with structurally sound tissue. Mice lacking the transcription factor Nuclear Matrix Protein 4 (Nmp4, Zfp384, Ciz, ZNF384) respond to several classes of osteoporosis drugs with enhanced bone formation compared to wild type (W...
作者:Childress Paul J , Maupin Kevin A ...
来源:[J].Stem cells and development, 2018, Vol.27 (10), pp.671-682PubMed
摘要:Emerging evidence demonstrates that megakaryocytes (MK) play key roles in regulating skeletal homeostasis and hematopoiesis. To test if the loss of MK negatively impacts osteoblastogenesis and hematopoiesis, we generated conditional knockout mice where Mpl, the receptor for ...
作者:Childress Paul J , Abeysekera Irushi ...
来源:[J].Blood advances, 2017, Vol.1 (26), pp.2520-2528PubMed
摘要:Networking between hematopoietic stem cells (HSCs) and cells of the hematopoietic niche is critical for stem cell function and maintenance of the stem cell pool. We characterized calvariae-resident osteomacs (OMs) and their interaction with megakaryocytes to sustain HSC function ...
作者:Childress Paul J , Fearon Angela M ...
来源:[J].Connective tissue research, 2013PubMed
摘要:Abstract The Achilles tendon is a frequent site for degeneration, and advanced understanding of this pathology requires an animal model that replicates the human condition. The aim of this study was to explore whether intratendinous collagenase injection combined with treadm...
作者:Childress Paul J , Bidwell Joseph P ...
来源:[J].Endocrinology, 2011, Vol.152 (8), pp.2963-75PubMed
摘要:PTH is a potent calcium-regulating factor that has skeletal anabolic effects when administered intermittently or catabolic effects when maintained at consistently high levels. Bone cells express PTH receptors, but the cellular responses to PTH in bone are incompletely unders...
作者:Childress Paul J , Robling Alexander G ...
来源:[J].AJP: Endocrinology and Metabolism (Online), 2009, Vol.298 (3), pp.E714-25PubMed
摘要:Parathyroid hormone (PTH) restores bone mass to the osteopenic skeleton, but significant questions remain as to the underlying mechanisms. The receptor for advanced glycation end products (RAGE) is a multiligand receptor of the immunoglobulin superfamily; however, recent studies ...

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