PubMed期刊
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作者:... Al-Jammaz Ibrahim , Al-Khalaf Huda H , Aboussekhra Abdelilah
来源:[J].BMC cancer(IF 3.333), 2016, Vol.16 (1), pp.540PubMed
摘要:Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, novel molecules and therapeutic options are urgently needed for this c...
作者:Al-Khalaf Huda H , Aboussekhra Abdelilah
来源:[J].Age, 2013PubMed
摘要:Survivin, an important anti-apoptotic protein, is highly expressed in most cancers, which generally arise in cells of older individuals. We have shown here accumulation of survivin and phospho-survivin in aged normal human skin fibroblasts and mice organs. This age-related a...
作者:Al-Khalaf Huda H , Hendrayani Siti-Faujiah , Aboussekhra Abdelilah
来源:[J].Molecular Cancer Research, 2011, Vol.9 (3), pp.311-9PubMed
摘要:The tumor suppressor p16(INK4A), a phosphoprotein that exists in human cells under both phosphorylated and nonphosphorylated forms, plays crucial roles during the cellular response to UV light. However, it is still unclear how this protein is activated in response to this carcino...
作者:Al-Khalaf Huda H , Colak Dilek ...
来源:[J].PL o S One(IF 3.73), 2011, Vol.6 (7), pp.e21111PubMed
摘要:The cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and their functional interplay are still no...
作者:Al-Khalaf Huda H , Hendrayani Siti-Faujiah , Aboussekhra Abdelilah
来源:[J].Molecular Carcinogenesis, 2011PubMed
摘要:The universal cyclin-dependent kinase inhibitor p21(WAF1/Cip1) promotes cell cycle arrest and inhibits apoptosis in response to UV-induced DNA damage. Since the protein kinase ATR plays a major role in the cellular response to these carcinogenic lesions, we investigated the ...
作者:Al-Khalaf Huda H , Lach Boleslaw ...
来源:[J].Brain Research(IF 2.879), 2007, Vol.1188, pp.25-34PubMed
摘要:Although meningiomas represent the most common class of tumors of the central nervous system, the molecular events underlying their genesis and development are still not well defined, and therapeutic approaches based on the genetics of these tumors are currently lacking. In the p...
作者:Al-Khalaf Huda H , Lach Boleslaw ...
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2007, Vol.83 (1), pp.9-15PubMed
摘要:Although meningiomas represent the most common class of tumors of the central nervous system, the molecular events underlying their genesis and development are still not well defined. In the present study we have used the immuno-blotting technique to study the expression level of...
作者:Al-Khalaf Huda H , Al-Yousef Nujoud
来源:[J].Nucleic Acids Research, 2006, Vol.35 (1), pp.223-33PubMed
摘要:p16INK4a and p21WAF1, two major cyclin-dependent kinase inhibitors, are the products of two tumor suppressor genes that play important roles in various cellular metabolic pathways. p21WAF1 is up-regulated in response to different DNA damaging agents. While the activation of p21WA...

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