PubMed期刊
期刊
会议
图书
作者:Akbar Arne N , Fletcher Jean M
来源:[J].Current Opinion in Immunology(IF 8.771), 2005, Vol.17 (5), pp.480-5PubMed
摘要:Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are dri...
作者:Akbar Arne N , Aquino Alessandra ...
来源:[J].Experimental Gerontology(IF 3.911), 2007, Vol.42 (10), pp.995-1002PubMed
摘要:Herpes viruses (particularly CMV and to some extent EBV) might play a role in accelerating the deterioration of immune functions with age. Indeed, it has been demonstrated that chronic infection with CMV causes an expansion of specific CD8 T lymphocytes and that this is related t...
作者:Akbar Arne N , Buckley Christopher D
来源:[J].Methods in molecular medicine, 2007, Vol.136, pp.117-38PubMed
摘要:T-cell apoptosis is central to the resolution of chronic inflammation. Inhibition of this process of programmed cell death contributes to disease persistence in conditions such as rheumatoid arthritis. An understanding of T-cell apoptosis and its regulation is clearly important f...
作者:Akbar Arne N , Robinson Douglas S ...
来源:[J].Immunology(IF 3.705), 2006, Vol.118 (1), pp.1-9PubMed
摘要:Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory pathologies in vivo. At a recent meeting [Clinical Application of Regulatory...
作者:... Curnow S John , Vukmanovic-Stejic M , Akbar Arne N
来源:[J].Inflammation & Allergy - Drug Targets, 2006, Vol.5 (3), pp.149-56PubMed
摘要:CD4+CD25+ regulatory T cells are essential components of the immune system. They help to maintain immune tolerance by exerting suppressive effects on cells of the adaptive and innate immune system. In the last few years there has been an abundance of papers addressing the suppres...
作者:... Beverley Peter C L , Macallan Derek C , Akbar Arne N
来源:[J].Journal of Clinical Investigation(IF 12.812), 2006, Vol.116 (9), pp.2423-33PubMed
摘要:While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+ CD45RO+ CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium labeling of cycling cells in vivo to determine whether these cells could be re...
作者:... Lacy Katie E , Rustin Malcolm H A , Akbar Arne N
来源:[J].Immunology Letters(IF 2.337), 2006, Vol.107 (2), pp.93-101PubMed
摘要:The Mantoux Test (MT) is a classical delayed-type hypersensitivity (DTH) response to the intradermal injection of tuberculin purified protein derivative (PPD). It represents a cutaneous T cell mediated memory recall immune response. The test is typically used to determine im...
作者:Akbar Arne N , Tough David F
来源:[J].Immunology(IF 3.705), 2006, Vol.119 (2), pp.243-53PubMed
摘要:Interleukin (IL)-7 and IL-15 are cytokines implicated in homeostatic control of the peripheral CD8 T-cell pool. We compared the effects of IL-7 and IL-15 on survival and proliferation of purified human CD8+ T-cell subsets. Low concentrations of either cytokine reduced the sp...
作者:Akbar Arne N , Bijlsma Johannes W J
来源:[J].Human Immunology(IF 2.298), 2005, Vol.66 (3), pp.222-30PubMed
摘要:The suppressive effects of CD4+CD25+ regulatory T cells (Tregs) on T cells have been well documented. Here we investigated whether human CD4+CD25+ Tregs can inhibit the proinflammatory properties of monocytes/macrophages. Monocytes and T cells were isolated from peripheral blood ...
作者:... Lam Eric W-F , Salmon Mike , Akbar Arne N
来源:[J].Blood(IF 9.06), 2005, Vol.106 (2), pp.558-65PubMed
摘要:After acute infection Epstein-Barr virus (EBV)-specific memory CD8+ T cells exit cell cycle, and a proportion of these antigen-experienced cells re-express CD45RA (CD45 which predominantly express exon A). However, the signals involved are not known. We investigated the roles of ...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×