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作者:... Mills Rachel S , Henson Sian M , Akbar Arne N
来源:[J].Journal of immunology (Baltimore, Md. : 1950), 2016, Vol.197 (7), pp.2891-9PubMed
摘要:NK cells are the first line of defense against infected and transformed cells. Defective NK cell activity was shown to increase susceptibility for viral infections and reduce tumor immune-surveillance. With age, the incidence of infectious diseases and malignancy rises dramatical...
作者:... Nourshargh Sussan , Akbar Arne N , Henson Sian M
来源:[J].Aging cell, 2018, Vol.17 (1)PubMed
摘要:Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8+ T cells also display a SASP comprising chemokines, cytokines and extracellular matrix remodelling proteases that are unique to ...
作者:Akbar Arne N , Henson Sian M , Lanna Alessio
来源:[J].Trends in immunology, 2016, Vol.37 (12), pp.866-876PubMed
摘要:As humans live longer, a central concern is to find ways to maintain their health as they age. Immunity declines during ageing, as shown by the increased susceptibility to infection by both previously encountered and new pathogens and by the decreased efficacy of vaccination. It ...
作者:... Lee Jun Hee , Karin Michael , Akbar Arne N
来源:[J].Nature immunology, 2017, Vol.18 (3), pp.354-363PubMed
摘要:Mitogen-activated protein kinases (MAPKs) including Erk, Jnk and p38 regulate diverse cellular functions and are thought to be controlled by independent upstream activation cascades. Here we show that the sestrins bind to and coordinate simultaneous Erk, Jnk and p38 MAPK activati...
作者:Akbar Arne N , Beverley Peter C L , Salmon Mike
来源:[J].Nature Reviews. Immunology(IF 33.129), 2004, Vol.4 (9), pp.737-43PubMed
摘要:Evidence is accumulating that elderly individuals are more susceptible to infection with organisms to which they were previously immune. This indicates that there might be a limit to the persistence of immune memory. This fact is particularly disturbing because the average life e...
作者:Akbar Arne N
来源:[J].Blood, 2010, Vol.116 (16), pp.2869-70PubMed
作者:Akbar Arne N , Vukmanovic-Stejic Milica ...
来源:[J].Nature Reviews. Immunology(IF 33.129), 2007, Vol.7 (3), pp.231-7PubMed
摘要:Whereas memory T cells are required to maintain immunity, regulatory T cells have to keep the immune system in check to prevent excessive inflammation and/or autoimmunity. Both cell types must be present during the lifetime of the organism. However, it is not clear whether both s...
作者:Akbar Arne N , Vukmanovic-Stejic Milica
来源:[J].Journal of Immunology(IF 5.52), 2007, Vol.178 (11), pp.6689-94PubMed
摘要:The enzyme telomerase counteracts telomere loss in proliferating cells and extends their capacity for replication. The importance of telomerase is highlighted by the award of the 2006 Albert Lasker Prize for Basic Medical Research for its discovery. Malignant cells subvert telome...
作者:Akbar Arne N , Fletcher Jean M
来源:[J].Current Opinion in Immunology(IF 8.771), 2005, Vol.17 (5), pp.480-5PubMed
摘要:Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are dri...

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