作者:Akbar Arne N
来源:[J].Blood, 2010, Vol.116 (16), pp.2869-70PubMed
作者:Akbar Arne N , Vukmanovic-Stejic Milica ...
来源:[J].Nature Reviews. Immunology(IF 33.129), 2007, Vol.7 (3), pp.231-7PubMed
摘要:Whereas memory T cells are required to maintain immunity, regulatory T cells have to keep the immune system in check to prevent excessive inflammation and/or autoimmunity. Both cell types must be present during the lifetime of the organism. However, it is not clear whether both s...
作者:Akbar Arne N , Vukmanovic-Stejic Milica
来源:[J].Journal of Immunology(IF 5.52), 2007, Vol.178 (11), pp.6689-94PubMed
摘要:The enzyme telomerase counteracts telomere loss in proliferating cells and extends their capacity for replication. The importance of telomerase is highlighted by the award of the 2006 Albert Lasker Prize for Basic Medical Research for its discovery. Malignant cells subvert telome...
作者:Akbar Arne N , Fletcher Jean M
来源:[J].Current Opinion in Immunology(IF 8.771), 2005, Vol.17 (5), pp.480-5PubMed
摘要:Human memory T cell pools proliferate and differentiate at varying rates that are determined by the frequency of lifelong antigenic re-encounter with different specific antigens. An important question concerning immunity is whether certain specific pools of memory T cells are dri...
作者:... Beverley Peter C , Akbar Arne N , Macallan Derek C
来源:[J].Immunology, 2010, Vol.132 (1), pp.27-38PubMed
摘要:The immune response to human cytomegalovirus (HCMV) infection is characterized by the accumulation of HCMV-specific CD8(+) T cells, particularly in the elderly; such expansions may impair immune responses to other pathogens. We investigated mechanisms underlying HCMV-specifi...
作者:... Kern Florian , Soares Maria V D , Akbar Arne N
来源:[J].Immunology, 2011, Vol.132 (3), pp.326-39PubMed
摘要:The relative roles that ageing and lifelong cytomegalovirus (CMV) infection have in shaping naive and memory CD4+ T-cell repertoires in healthy older people is unclear. Using multiple linear regression analysis we found that age itself is a stronger predictor than CMV seropo...
作者:... Zhang Yan , Akbar Arne N , Macallan Derek C
来源:[J].Methods in Molecular Biology, 2011, Vol.707, pp.243-61PubMed
摘要:The in vivo proliferation and disappearance kinetics of lymphocytes may be estimated in humans from rates of deuterium-labeled glucose ((2)H(2)-glucose) incorporation into DNA. This protocol describes its application to regulatory T cells (Treg). Because Treg divide frequent...
作者:... Rustin Malcolm H A , Nikolich-Zugich Janko , Akbar Arne N
来源:[J].Current Opinion in Immunology, 2011, Vol.23 (4), pp.525-31PubMed
摘要:A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in imm...
作者:... Soares Maria V D , Battistini Luca , Akbar Arne N
来源:[J].Journal of Immunology, 2011, Vol.187 (5), pp.2093-100PubMed
摘要:Persistent viral infections and inflammatory syndromes induce the accumulation of T cells with characteristics of terminal differentiation or senescence. However, the mechanism that regulates the end-stage differentiation of these cells is unclear. Human CD4(+) effector memo...
作者:... ten Berge Ineke J M , Akbar Arne N , van Lier René A W
来源:[J].Journal of Immunology, 2010, Vol.184 (7), pp.3417-23PubMed
摘要:Short telomeres of circulating leukocytes are a risk factor for age-related diseases, such as atherosclerosis, but the exact mechanisms generating variations in telomere length are unknown. We hypothesized that induction of differentiated T cells during chronic CMV infection woul...


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