作者:... Al-Jammaz Ibrahim , Al-Khalaf Huda H , Aboussekhra Abdelilah
来源:[J].BMC cancer(IF 3.333), 2016, Vol.16 (1), pp.540PubMed
摘要:Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, novel molecules and therapeutic options are urgently needed for this c...
作者:Al-Rakan Maha A , Hendrayani Siti-Faujiah , Aboussekhra Abdelilah
来源:[J].BMC cancer(IF 3.333), 2016, Vol.16 (1), pp.575PubMed
摘要:Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibroblast activation, and their paracrine pro-carcinogenic effects are still ...
作者:... Al-Mohanna Falah H , Tulbah Asma , Aboussekhra Abdelilah
来源:[J].Oncotarget(IF 6.636), 2018, Vol.9 (2), pp.2329-2343PubMed
摘要:The activation of breast stromal fibroblasts is a crucial step toward tumor growth and spread. Therefore, it is extremely important to understand the molecular basis of this activation and determine the molecules and the mechanisms responsible for its sustainability. In the ...
作者:... Hendrayani Siti-Fauziah , Silva Gabriela , Aboussekhra Abdelilah
来源:[J].Oncotarget(IF 6.636), 2018, Vol.9 (25), pp.17825-17838PubMed
摘要:Cancer-associated fibroblasts (CAFs) are major players in the development and spread of breast carcinomas through non-cell-autonomous signaling. These paracrine effects are under the control of several genes and microRNAs. We present here clear evidence that let-7b, a tumor suppr...
作者:... Al-Mazrou Amer , Remmal Adnane , Aboussekhra Abdelilah
来源:[J].Molecular carcinogenesis, 2018, Vol.57 (3), pp.333-346PubMed
摘要:Triple-negative breast tumors are very aggressive and contain relatively high proportion of cancer stem cells, and are resistant to chemotherapeutic drugs including cisplatin. To overcome these limitations, we combined eugenol, a natural polyphenolic molecule, with cisplatin...
作者:Al-Khalaf Huda , Aboussekhra Abdelilah
来源:[J].Molecular cancer research : MCR, 2018PubMed
摘要:p16INK4A and p53 are two major tumor suppressor proteins, which are both up-regulated in response to various cellular stresses and during senescence and aging. p53 is a well characterized transcription factor, while p16INK4A a cyclin-dependent kinase inhibitor encoded by the CDKN...
作者:... Tulbah Asma , Al-Sayed Adher , Aboussekhra Abdelilah
来源:[J].Molecular and cellular biology, 2017, Vol.37 (17)PubMed
摘要:Obesity is increasingly recognized as a risk factor for breast cancer development. However, the molecular basis of obesity-related breast carcinogenesis remains elusive. In this study, we have shown that obesity reduces the level of the tumor suppressor p16INK4A protei...
作者:Al-Khalaf Huda H , Aboussekhra Abdelilah
来源:[J].Molecular carcinogenesis, 2017, Vol.56 (3), pp.985-999PubMed
摘要:Senescence and epithelial-to-mesenchymal transition (EMT) processes are under the control of common tumor suppressor proteins, EMT transcription factors, and microRNAs. However, the molecular mechanisms that coordinate the functional link between senescence and EMT are still...
作者:Aboussekhra Abdelilah , Al-Sharif Ibtehaj S
来源:[J].The EMBO Journal(IF 9.822), 2005, Vol.24 (11), pp.1999-2010PubMed
摘要:To efficiently protect the integrity of genetic information, transcription is connected to nucleotide excision repair (NER), which allows preferential repair of the transcribed DNA strands (TS). As yet, the molecular basis of this connection remains elusive in eukaryotic cells. H...
作者:Aboussekhra Abdelilah
来源:[J].The International Journal of Developmental Biology, 2011, Vol.55 (7-9), pp.841-9PubMed
摘要:Since Paget's "Seed and Soil" hypothesis in 1889 on cancer growth and metastasis, several studies on various solid tumors have confirmed the active role of the tumor milieu on the onset, growth and spread of neoplastic cells. Fibroblasts constitute the major components ...


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