PubMed期刊
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作者:Aboussekhra Abdelilah , Al-Sharif Ibtehaj S
来源:[J].The EMBO Journal(IF 9.822), 2005, Vol.24 (11), pp.1999-2010PubMed
摘要:To efficiently protect the integrity of genetic information, transcription is connected to nucleotide excision repair (NER), which allows preferential repair of the transcribed DNA strands (TS). As yet, the molecular basis of this connection remains elusive in eukaryotic cells. H...
作者:... Al-Omeir Abeer , Al-Ahdal Mohammed N , Aboussekhra Abdelilah
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2005, Vol.72 (3), pp.203-8PubMed
摘要:Survivin, an inhibitor of apoptosis, is over-expressed in foetal tissues and human cancers, but it is almost undetectable in normal tissues. Here we have assessed the level of the survivin protein in some benign tumors of the nervous system: meningioma, schwannoma, low-grade epen...
作者:... Al-Mukhalafi Zuha , A Al-Hussein Khaled , Aboussekhra Abdelilah
来源:[J].Oncogene(IF 7.357), 2004, Vol.23 (1), pp.201-12PubMed
摘要:p16(INK4a) (hereafter referred to as p16), a major cyclin-dependent kinase (CDK) inhibitor, is the product of a tumor-suppressor gene that has been found inactivated in different cancer types. In the present study, we sought to investigate the role of p16 in apoptosis induced by ...
作者:... Al-Jammaz Ibrahim , Al-Khalaf Huda H , Aboussekhra Abdelilah
来源:[J].BMC cancer(IF 3.333), 2016, Vol.16 (1), pp.540PubMed
摘要:Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens. Therefore, novel molecules and therapeutic options are urgently needed for this c...
作者:Al-Rakan Maha A , Hendrayani Siti-Faujiah , Aboussekhra Abdelilah
来源:[J].BMC cancer(IF 3.333), 2016, Vol.16 (1), pp.575PubMed
摘要:Active fibroblasts, the predominant and the most active cells of breast cancer stroma, are responsible for tumor growth and spread. However, the molecular mediators and pathways responsible for stromal fibroblast activation, and their paracrine pro-carcinogenic effects are still ...
作者:Aboussekhra Abdelilah
来源:[J].The International Journal of Developmental Biology, 2011, Vol.55 (7-9), pp.841-9PubMed
摘要:Since Paget's "Seed and Soil" hypothesis in 1889 on cancer growth and metastasis, several studies on various solid tumors have confirmed the active role of the tumor milieu on the onset, growth and spread of neoplastic cells. Fibroblasts constitute the major components ...
作者:Al-Khalaf Huda H , Aboussekhra Abdelilah
来源:[J].Age, 2013PubMed
摘要:Survivin, an important anti-apoptotic protein, is highly expressed in most cancers, which generally arise in cells of older individuals. We have shown here accumulation of survivin and phospho-survivin in aged normal human skin fibroblasts and mice organs. This age-related a...
作者:... Elkum Naser , Al-Tweigeri Taher , Aboussekhra Abdelilah
来源:[J].Oncology Letters, 2012, Vol.3 (4), pp.875-878PubMed
摘要:Breast cancer has a major impact on the health of women worldwide. In the Kingdom of Saudi Arabia (KSA), breast cancer incidence is on the increase and is characterized by early onset and aggressiveness. Owing to the importance of the TP53 gene in breast carcinogenesis, we a...
作者:Al-Moghrabi Nisreen M , Al-Sharif Ibtehaj S , Aboussekhra Abdelilah
来源:[J].DNA Repair(IF 4.274), 2003, Vol.2 (11), pp.1185-97PubMed
摘要:DNA damage results in the up-regulation of several genes involved in different cellular physiological processes, such as the nucleotide excision repair (NER) mechanism that copes with a broad range of DNA alterations, including the carcinogenic ultraviolet (UV) light-induced pyri...
作者:... Siewertsen Monica , Al-Ahdal Mohammed N , Aboussekhra Abdelilah
来源:[J].Carcinogenesis(IF 5.635), 2002, Vol.23 (10), pp.1617-24PubMed
摘要:Ataxia-telangiectasia (A-T), is an autosomal recessive disease characterized by neurological and immunological symptoms, radiosensitivity and cancer predisposition. A-T cells exhibit a greatly decreased survival and a reduction in DNA synthesis inhibition as well as p53 induction...

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