European Cells and Materials (eCM)
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作者:C Knuth , C Kiernan , E Wolvius ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.277-291European Cells and Materials (eCM)
摘要:Endochondral ossification (EO) is the process by which the long bones of the body form and has proven to be a promising method in tissue engineering for achieving cell-mediated bone formation. The present review centred on state-of-the-art research pertaining to mesenchymal stem ...
作者:E López-Ruiz , G Jiménez , L Álvarez de Cienfuegos ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.186-213European Cells and Materials (eCM)
摘要:Hyaluronic acid (HA), as one of the main components of the extracellular matrix (ECM), plays a significant role in a multitude of biological processes involving cell migration, proliferation, differentiation, wound healing and inflammation. Thanks to its excellent biocompati...
作者:I Iezzi , P Pagella , M Mattioli-Belmonte ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.175-185European Cells and Materials (eCM)
摘要:Stem cells are essential for tissue homeostasis and regeneration throughout the lifespan of multicellular rganisms. The decline in stem cell function during advanced age is associated with a reduced regenerative potential of tissues that leads to an increased frequency of disease...
作者:S Nürnberger , C Lindner , J Maier ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.113-133European Cells and Materials (eCM)
摘要:The prerequisite for a successful clinical use of autologous adipose-tissue-derived cells is the highest possible regenerative potential of the applied cell population, the stromal vascular fraction (SVF). Current isolation methods depend on high enzyme concentration, lysis buffe...
作者:A Islam , I Urbarova , J A Bruun ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.153-174European Cells and Materials (eCM)
摘要:Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little ...
作者:A R Pereira , D Trivanović , M Herrmann
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.88-112European Cells and Materials (eCM)
摘要:Mesenchymal stem/stromal cells (MSCs) are an essential element of most modern tissue engineering and regenerative medicine approaches due to their multipotency and immunoregulatory functions. Despite the prospective value of MSCs for the clinics, the stem cells community is ...
作者:R M Aspden , F R Saunders
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.74-87European Cells and Materials (eCM)
摘要:Considered for decades as a cartilage disease, recent studies of osteoarthritis (OA) take us back to the concepts discussed at the naming of the disorder as “bone-joint-inflammation”. By describing the joint as an organ, can OA be called an organ disease – similar to he...
作者:J M McKinney , T N Doan , L Wang ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.42-59European Cells and Materials (eCM)
摘要:Mesenchymal stem cells (MSCs) represent a great therapeutic promise in pre-clinical models of osteoarthritis (OA), but many questions remain as to their therapeutic mechanism of action: engraftment versus paracrine action. Encapsulation of human MSCs (hMSCs) in sodium algina...
作者:R Duan , L A van Dijk , D Barbieri ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.60-73European Cells and Materials (eCM)
摘要:Osteoinductive calcium phosphate (CaP) bone grafts have equivalent performance to autografts in repairing critical-size bone defects. The osteoinductive potential of CaP is linked to the size of the surface topographical features. In the present study, two novel biphasic cal...
作者:A Levillain , R A Rolfe , Y Huang ...
来源:[J].Eur Cell Mater(IF 4.558), 2019, Vol.37, pp.23-41European Cells and Materials (eCM)
摘要:Congenital spine deformities may be influenced by movements in utero, but the effects of foetal immobility on spine and rib development remain unclear. The purpose of the present study was to determine (1) critical time-periods when rigid paralysis caused the most severe disrupti...

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