European Cells and Materials (eCM)
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作者:P De Luca , L de Girolamo , E Ragni ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.156-170
摘要:Degenerative processes of the intervertebral disc (IVD) and cartilaginous endplate lead to chronic spine pathologies. Several studies speculated on the intrinsic regenerative capacity of degenerated IVD related to the presence of local mesenchymal progenitors. However, a complete...
作者:S Ahmed
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.136-155
摘要:The establishment of a complex collagen network is critical for the architecture and mechanical properties of cartilage and bone. However, when and how the key collagens in cartilage and bone develop has not been characterised in detail. The study provides a detailed qualitative ...
作者:A Longoni , I E van Hooijdonk , G K Bittermann ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.121-135
摘要:Dental pulp stem cells (DPSCs) are particularly promising for tissue engineering (TE) due to the ease of their isolation procedure, great expansion potential and capability to differentiate towards several cell types of the mesodermal, ectodermal and endodermal lineages. Although...
作者:W Boot , C Jiao , P G Nikkels ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.108-120
摘要:Local prophylaxis with antibiotic-loaded bone cement is a successful method to prevent post-operative infections in patients receiving orthopaedic implants. No comparable method is available for uncemented implants. Therefore, a hydrogel consisting of hyaluronic and polylactic ac...
作者:C C Lee , C Jiao , E Gersz ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.96-107
摘要:Staphylococcus aureus (S. aureus) osteomyelitis remains a major clinical problem. Anti-glucosaminidase (Gmd) antibodies (1C11) are efficacious in prophylactic and therapeutic murine models. Feasibility, safety and pharmacokinetics of 1C11 passive immunisation in sheep and en...
作者:S M Shiels , J C Wenke
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.77-95
摘要:Orthopaedic implant use increases infection risk. Implant infection risk can be explained by the “race for the surface” concept, where there is competition between host-cell integration and bacterial colonisation. Although generally accepted, the temporal dynamics have not b...
作者:M Alaqeel , L M Epure , O Salem ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.65-76
摘要:Osteoarthritis (OA) is a disease of diarthrodial joints associated with extracellular matrix proteolytic degradation under inflammatory conditions, pain and disability. Currently, there is no therapy to prevent, reverse or modulate the disease course. The present study aimed...
作者:E Delve , V Co , S C Regmi ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.48-64
摘要:The roles of cell division control protein 42 homologue (CDC42) and actin polymerisation in regulating the phenotype of superficial-zone chondrocytes (SZCs) have been demonstrated in vitro; however, the signalling pathway(s) downstream have yet to be fully elucidated. The study h...
作者:M Fusellier , J Clouet , O Gauthier ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.18-47
摘要:Appropriate cell sources, bioactive factors and biomaterials for generation of functional and integrated annulus fibrosus (AF) tissue analogues are still an unmet need. In the present study, the AF cell markers, collagen type I, cluster of differentiation 146 (CD146), mohawk...
作者:J Du , R G Long , T Nakai ...
来源:[J].Eur Cell Mater(IF 4.558), 2020, Vol.39, pp.1-17
摘要:Appropriate cell sources, bioactive factors and biomaterials for generation of functional and integrated annulus fibrosus (AF) tissue analogues are still an unmet need. In the present study, the AF cell markers, collagen type I, cluster of differentiation 146 (CD146), mohawk...

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