European Cells and Materials (eCM)
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作者:A Sadowska , T Kameda , O Krupkova ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.231-250European Cells and Materials (eCM)
摘要:Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with...
作者:S Khatab , G J van Osch , N Kops ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.218-230European Cells and Materials (eCM)
摘要:Mesenchymal stem cells (MSCs) represent a promising biological therapeutic option as an osteoarthritis (OA)-modifying treatment. MSCs secrete factors that can counteract inflammatory and catabolic processes and attract endogenous repair cells. The effects of intra-articular ...
作者:D H Rosenzweig , R Fairag , A P Mathieu ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.200-217European Cells and Materials (eCM)
摘要:Numerous studies show promise for cell-based tissue engineering strategies aiming to repair painful intervertebral disc (IVD) degeneration. However, clinical translation to human IVD repair is slow. In the present study, the regenerative potential of an autologous nucleus pu...
作者:R Hartman , P Patil , R Tisherman ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.171-183European Cells and Materials (eCM)
摘要:Robust cellular bioenergetics is vital in the energy-demanding process of maintaining matrix homeostasis in the intervertebral disc. Age-related decline in disc cellular bioenergetics is hypothesised to contribute to the matrix homeostatic perturbation observed in intervertebral ...
作者:N Vanvelk , M Morgenstern , T F Moriarty ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.184-199European Cells and Materials (eCM)
摘要:A fracture-related infection (FRI) is an important complication that can lead to an increase in morbidity, mortality and economic costs. Preclinical in vivo models are critical in the evaluation of novel prevention and treatment strategies, yet it is important that these studies ...
作者:A Martin-Pena , R M Porter , G Plumton ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.156-170European Cells and Materials (eCM)
摘要:Successful clinical translation of mesenchymal stem cell (MSC)-based therapies for cartilage repair will likely require the implementation of standardised protocols and broadly applicable tools to facilitate the comparisons among cell types and chondroinduction methods. The ...
作者:J Xu , A Nyga , W Li ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.142-155European Cells and Materials (eCM)
摘要:Many studies report the adverse responses to metal-on-metal (MoM) hip prostheses, with tissues surrounding failed MoM hip prostheses revealing abundant tissue necrosis and fibrosis. These local effects appear to be initiated by metal ions released from the prosthesis causing the ...
作者:L Germain , D Larouche , B Nedelec ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.128-141European Cells and Materials (eCM)
摘要:Split-thickness skin autografts (AGs) are the standard surgical treatment for severe burn injuries. However, the treatment of patients with substantial skin loss is limited by the availability of donor sites for skin harvesting. As an alternative to skin autografts, our rese...
作者:R Castro-Viñuelas , C Sanjurjo-Rodríguez , M Piñeiro-Ramil ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.96-109European Cells and Materials (eCM)
摘要:The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. Human mesenchymal stromal cells (MSCs) are prone to form epiphyseal or hypertrophic cartilage and hav...
作者:J Antons , M G Marascio , P Aeberhard ...
来源:[J].Eur Cell Mater(IF 4.558), 2018, Vol.36, pp.81-95European Cells and Materials (eCM)
摘要:Tissue decellularisation has gained much attention in regenerative medicine as an alternative to synthetic materials. In decellularised tissues, biological cues can be maintained and provide cellular environments still unmet by synthetic materials. Supercritical CO 2 (scCO 2...

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